DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and yl

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:2215 Identity:603/2215 - (27%)
Similarity:895/2215 - (40%) Gaps:513/2215 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PSATTLLTHDPANGDSHTAADPLQVTDAAPSGPPSSSSSSPIGDRHSQHHSSSAIDRRLQQQQHH 93
            ||...:....|....|....:....|.|.||.  ..|:||..|:....|...:            
  Fly    10 PSEQRIRVESPKMTASRRGFNLTSQTRAHPSS--GGSTSSRYGNCQRTHLIIN------------ 60

  Fly    94 QSPQHHRQRGQLTTLALLLLALVAISNLETLLAVRTEGPRNRHGSPGGSLASTGGSSSGINTECP 158
                     |:...::||||.                      |..||:.|.|.||:   :|.|.
  Fly    61 ---------GRHVAISLLLLV----------------------GLCGGTAAGTPGSA---DTRCD 91

  Fly   159 TDSFRCNNGKCISHHWVCNYQKDCDDGEDEMQSCPPPECETPQLNCGQYTFNKTYCIPPHYRCDM 223
            ...|:|.:|.||....:|       ||..                                    
  Fly    92 AGQFQCRDGGCILQAKMC-------DGRG------------------------------------ 113

  Fly   224 IEDCEDKSDEAQCTYRKCQHTDLF-CNTPTGAPAEGARLTGPCVPKEKRCDGYLDCRTGRDEVGC 287
              ||:|.|||..|.||.|:....| |..|.||          |:..|..|:|..:|..|.||:.|
  Fly   114 --DCKDSSDELDCDYRLCRPPHWFPCAQPHGA----------CLAAELMCNGIDNCPGGEDELNC 166

  Fly   288 ---SGV----------ACRLDQFRCANGLKCIDAALKCNHRDDCGDNSDE-QGCNFP--PCHHAQ 336
               .|.          :|...:|.|.....||.....|:.|.||.|.||| .||...  .|....
  Fly   167 PVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEG 231

  Fly   337 FRCTNALCI-PYNFHCDGYHDCADKSDEANCTAIACPD-NKHLCPRGGASGTPKCILKSQLCDGK 399
            ..|.|..|: ...:.|||..||.|.|||..|..:..|. .|.||     .....|:..|::|||.
  Fly   232 HLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCEPQKGKFLC-----RNRETCLTLSEVCDGH 291

  Fly   400 RDCEDGSDEETNC-SIASCPALSCEF--KCG--PSLTGGVCYCKPGQSLAPDNRTCVDLDECAEW 459
            .||.|||||...| |...|.|..|..  ||.  |: :|..|:|..|..||.....|.|:|||.|.
  Fly   292 SDCSDGSDETDLCHSKPDCDAKKCALGAKCHMMPA-SGAECFCPKGFRLAKFEDKCEDVDECKEQ 355

  Fly   460 GH-CDQLCTNTLGSYTCQCAQGYTLINDSK-CIAPDANNLQ----LIFAHDRAIMRMLPHGSEP- 517
            .. |.|.|.||.|.|.|.|..||.|..|:: |.|....:.:    |::.....||.|  |..|. 
  Fly   356 DDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGM--HLREDN 418

  Fly   518 ------KILANATAAAGVTFHYARNTLYWSDIKTRKVQSLPL---DAQNKAVSPFDQTLPGTWAP 573
                  ::..|.:...||.  |..:.:||::|: .:.:|:..   |..|..:    ....|..||
  Fly   419 VRNHVYQVAGNLSKVIGVA--YDGSHIYWTNIQ-NEAESIVKANGDGSNAEI----LLTSGLDAP 476

  Fly   574 VALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAGLMFVADGGQ--- 635
            ..|||||:...||.:|.:.:.|.|....|...||::..::..|..||:.|..||||..|.|:   
  Fly   477 EDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPM 541

  Fly   636 VLRAHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLDYIESVDYEGAHRVMVLRGQQVPS 700
            :.||.|||:.:|.|||:.....:|:.:|:..:|::|.|:.|..:::|..:|..|..||.| .:..
  Fly   542 IGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG-MLKH 605

  Fly   701 PSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTYKAKDIR---EPKGIIAV---HALSQPRV 759
            |..||:||:::||:|...:.:.:..||.|          ||.|   :.:.|.||   |...||  
  Fly   606 PYGLAIFEDQLYWSDWATKSVHACHKFSG----------KDHRILAKDRTIYAVHIYHPAKQP-- 658

  Fly   760 SNPCGNNNGGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLKLCKPVSEFLMYSQQR-FI-KG 822
            ::|.|..|..|:|:|::    ..|...|..|||..|.:|..|.:.|     .||..:|| || .|
  Fly   659 NSPHGCENATCSHLCLL----AEPEIGGHSCACPDGMRLAPDHRRC-----MLMEKRQRLFIGLG 714

  Fly   823 KVL----------EPVIEGFSDAIMPVVSRRARFVGLDFDARDEFIY--------YSDVLQDVIY 869
            :||          ..|.:.::   :|.:.             :|.:|        .:|..|.:|.
  Fly   715 QVLLEIEHTAFGRHQVSKSYT---LPCLI-------------NEMVYNRINGSLIIADNDQRLIL 763

  Fly   870 RVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVTHRRTLLK---NLKR 931
            ..........:::.|....|..||.|..|:|||:.|:.:..:.|||.:  |..|.|::   ..:.
  Fly   764 EFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQ--TRHRALIRFFPGQEV 826

  Fly   932 PRAIVVHPNRGFIF-FSEWDRPANITRANTDGSG--LLVFKNVTLGWPN-GLSIDFKEDRVYWCD 992
            |..:.|.|..|::: ..:..|.::|.:....|.|  :.||:: .||..: .|..|::...::|.|
  Fly   827 PIGLTVMPAEGYLYVVLKAKRHSHIDKIPLSGKGEQVHVFED-DLGDDDIKLVTDYETQTIFWSD 890

  Fly   993 ALLDHVQHANLDGTDIKTVNSRLVRHPFSI-VIHNDWMYITDWRLDAIIRLHKLT-GEQEEMMVR 1055
            :.|..:.::|......:....:| |.|:|: ::|:| ::..:.....|...||.. |.::.:.:.
  Fly   891 SDLGRISYSNYRVPHSQIFRGKL-RRPYSLAMVHHD-LFWNELGTPRIYWTHKSNMGPRKVIDIM 953

  Fly  1056 E---PQTNRLYGVKVYSHEVQRIA------DTQPCHRNNGGCQKICFAVPIGASNGTDGVTTSSP 1111
            |   |.....|......:.:...|      ::.||.:.||||..||    :|.            
  Fly   954 EKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHIC----VGE------------ 1002

  Fly  1112 SFGRLQSRCSCP-------YGERLADDQVSCIPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCD 1169
              |...|.|.||       .|.|...:.:.|                 :|.|::..|:..:..|:
  Fly  1003 --GPYHSICLCPAGFVYRDAGNRTCVEALDC-----------------EFRCHSGECLTMNHRCN 1048

  Fly  1170 GDDDCLDNSDEEQNC-------TKPTCGSNEFQCRSG-RCIPQNFRCDQENDCGDNSDEQEC--- 1223
            |..||:|||| |.||       .|..|..|:|.|.|| :|:.:..|||...||.|:||||.|   
  Fly  1049 GRRDCVDNSD-EMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKF 1112

  Fly  1224 -GNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTCAYFQFTCPRTGHCIPQSWV 1287
             .:..|...|..|.||:|:.:...||..|||||:|||....|...|....|.| .:|.||..||.
  Fly  1113 DKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQC-GSGSCIAGSWE 1176

  Fly  1288 CDGDDDCFDKQDEKD-CPPISCLANQFKCADLRQCVEESYKCDGIPDCNDGSDEVGC--PSMGPN 1349
            |||..||.|..||.| |...||..:..:|. |.||::.|..|||..||.|.|||:.|  .|...|
  Fly  1177 CDGRIDCSDGSDEHDKCVHRSCPPDMQRCL-LGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMN 1240

  Fly  1350 QCNLEKHFRCKST-GFCIPIAWHCDGSNDCSDHSDEQDCGQITCAQNFFKC-NNTNCVFKAYICD 1412
            ....|..::|.|. ..|:|....|:|:.:|....||.|||.: |:...||| :...|:.:.:.||
  Fly  1241 ISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDV-CSIYEFKCRSGRECIRREFRCD 1304

  Fly  1413 GKDDCGDNSDE-------------------GAEHACVPPPFKCPHGQWQCPGVSERCVNITSVCD 1458
            |:.||||.|||                   .:..:|.|..|.|..|:         ||:::.||:
  Fly  1305 GQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGE---------CVDLSRVCN 1360

  Fly  1459 DTPDCPNGSDEGEGCDLAECEHQAGQ--CSSFCQKTPNGALCVCPPGSEIGEDGYTCIDSNECDP 1521
            :.|||.||.|||..|..| |...:|:  |...|:.||.||:|.|..|..:..|..:|:|.:||..
  Fly  1361 NFPDCTNGHDEGPKCATA-CRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQE 1424

  Fly  1522 PGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVPI 1586
            ...|:|.|.||.|.|.|.|...::|..::.:||::...|..|..|...   |.:|.||     |:
  Fly  1425 QQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNE---VRNLSEQ-----PV 1481

  Fly  1587 IVENVVATASN---------MH----------TGTIFWSDMKLKKISRLDRGMEPQEIINTGLDL 1632
            :: ||..:|::         ||          .|.::..|::.|.|.|.           .||..
  Fly  1482 ML-NVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIVRA-----------LGLPA 1534

  Fly  1633 VEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQPR---GMCIDPSPGARWIFW-- 1692
            ...|:.||:..|:|.|.   ...|:.|.:...|:.....::..||   .:.:| ...|| ||:  
  Fly  1535 PTKLSVDWVTGNVYVLS---GAQEIQACSFVGRMCGRIVHVKSPRHVKHLAVD-GYHAR-IFYIV 1594

  Fly  1693 ---TDWGE-NPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADS---KLDFIDFCYYN 1750
               ..:|: :..:....:||:.|..::.....:...||.|...:.:||.|.   .|:.|.:....
  Fly  1595 IRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKT 1659

  Fly  1751 GTGRQQ--VLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLISQPLSIHV 1813
            |..|:.  :|..|:.|:||..||::|:..:        :::..........:....|...:||:|
  Fly  1660 GPMRRPEIMLQKSNALMHPSGLSVYENNAF--------IVNLGSVEAVQCALYGSRICHKISINV 1716

  Fly  1814 HHA--------SLQPM-TPNPCAGSRCQHLCLLSPSAPEGYSCKCRPGFKLLSEG-RCIEEENPF 1868
            .:|        |.||. ..:|||.:.|..|||   .|..||.|.|  |.:|::|| ||       
  Fly  1717 LNAQDIVVAGRSRQPQKASHPCAHAHCHGLCL---QADYGYECMC--GNRLVAEGERC------- 1769

  Fly  1869 LMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDRK-----------------------G 1910
                        |...|:..|     |:|..:|..|:.:.:                       |
  Fly  1770 ------------PHGSGNEVA-----VLGAVNSLELEHEHEQNGHFHWLMALFVLAAGSLIAGLG 1817

  Fly  1911 ETLYWVQGREDDDENCTI-YTTPYG--GGNKTLFLGIENGIVGAPYTIAFDWLGRNLYIGNRVAS 1972
            ...|..:.|...|.|..: :..|..  ||.|. ||..|....|..:|                 :
  Fly  1818 YMYYQYRQRGHTDLNINMHFQNPLATLGGTKA-FLEHERAEAGVGFT-----------------T 1864

  Fly  1973 NIEAVRVDGKQKYRTIILANDGY-------PNSVS---RPKQIAL-DP-----------TEGKLF 2015
            ....|...|.....|...|...:       ||::.   ||:|.|. ||           .|.||.
  Fly  1865 ETGTVSSRGSNDTFTTTSATSSFAAQQFSVPNALQRLLRPRQSASGDPMAQELLLESPSRESKLH 1929

  Fly  2016 WIDEG 2020
            .:|.|
  Fly  1930 ALDGG 1934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060 9/31 (29%)
LDLa 204..236 CDD:238060 6/31 (19%)
LDLa 292..327 CDD:238060 13/35 (37%)
LDLa 332..366 CDD:238060 13/34 (38%)
LDLa 371..412 CDD:238060 16/41 (39%)
vWFA <447..488 CDD:294047 19/41 (46%)
NHL 573..>716 CDD:302697 52/145 (36%)
NHL repeat 573..610 CDD:271320 14/36 (39%)
NHL repeat 616..654 CDD:271320 19/40 (48%)
NHL repeat 657..693 CDD:271320 9/35 (26%)
FXa_inhibition 763..805 CDD:291342 13/41 (32%)
LY 922..964 CDD:214531 9/45 (20%)
LY 973..1007 CDD:214531 8/34 (24%)
Ldl_recept_a 1188..1223 CDD:278486 17/35 (49%)
LDLa 1227..1259 CDD:197566 14/31 (45%)
LDLa 1268..1303 CDD:238060 17/35 (49%)
LDLa 1308..1343 CDD:238060 15/34 (44%)
LDLa 1356..1387 CDD:238060 9/31 (29%)
LDLa 1391..1423 CDD:197566 13/32 (41%)
LDLa 1435..1469 CDD:197566 11/33 (33%)
FXa_inhibition 1478..1513 CDD:291342 12/36 (33%)
FXa_inhibition 1522..1553 CDD:291342 10/30 (33%)
LY 1625..1665 CDD:214531 10/39 (26%)
LY 1667..1711 CDD:214531 10/52 (19%)
Ldl_recept_b 1690..1728 CDD:278487 8/43 (19%)
LY 1712..1754 CDD:214531 9/44 (20%)
LY 1986..2037 CDD:214531 15/57 (26%)
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
ylNP_996433.1 LDLa 90..124 CDD:238060 15/78 (19%)
LDLa 131..166 CDD:238060 13/44 (30%)
LDLa 184..216 CDD:238060 11/31 (35%)
LDLa 227..262 CDD:238060 13/34 (38%)
LDLa 271..302 CDD:238060 15/35 (43%)
FXa_inhibition 352..387 CDD:291342 15/34 (44%)
Ldl_recept_b 442..482 CDD:278487 11/44 (25%)
LY 466..508 CDD:214531 14/45 (31%)
Ldl_recept_b 529..569 CDD:278487 16/39 (41%)
LY 553..595 CDD:214531 12/41 (29%)
LY 596..637 CDD:214531 15/51 (29%)
FXa_inhibition 669..700 CDD:291342 11/34 (32%)
LY 774..815 CDD:214531 14/42 (33%)
LDLa 1032..1062 CDD:238060 12/30 (40%)
LDLa 1074..1109 CDD:238060 17/34 (50%)
LDLa 1118..1152 CDD:238060 16/33 (48%)
LDLa 1157..1189 CDD:197566 14/32 (44%)
LDLa 1198..1232 CDD:238060 15/34 (44%)
LDLa 1243..1279 CDD:238060 10/35 (29%)
LDLa 1283..1318 CDD:238060 15/34 (44%)
LDLa 1340..1371 CDD:197566 14/39 (36%)
FXa_inhibition 1388..1416 CDD:291342 10/27 (37%)
EGF_CA 1418..1452 CDD:214542 13/33 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45461694
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.640

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