Protein Alignment mgl and Lrp10

DIOPT Version :10

• Sequence 1: NP_572563.3
• Gene: mgl / 8674055
• FlyBaseID: FBgn0261260
• Length: 4769
• Species: Drosophila melanogaster
• Sequence 2: NP_001382489.1
• Gene: Lrp10 / 305880
• RGDID: 1310471
• Length: 712
• Species: Rattus norvegicus
• Alignment Length: 464
• Identity: 116/464 - (25%)
• Similarity: 142/464 - (30%)
• Gaps: 184/464 - (39%)

  Fly  3611 NGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDE 3675
            |..|.     |||  :..|.::|.::..             |.||.::..||||  ..:.|.:::
  Rat    27 NSACE-----APP--AVLLEVQGTLQRP-------------LGRDSRSSPANCT--WVILGSKEQ 69

  Fly  3676 KCIPWFWK----CDGEKDCKDGSDEP------ATCAPRH-------------------------- 3704
            .....|.|    |..|........:|      |...|..
  Rat    70 TVTVRFQKLHLACGSEHLILHSPLQPPVSLCEAPAGPLQLPGGNVTITYSYAGARAPMGQGFLLT 134

  Fly  3705 -------CRAGTFQCKNTNCTPSATICDGVDDCGDRSDEQNC-------DLPCP-------LSDF 3748
                   |....|||.|..|.|:|..|||:|.|||.|||..|       .:|.|       |.||
  Rat   135 YSQDWLLCLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGCRSDPFPNPVPAPTPPCNLTLEDF 199

  Fly  3749 --KCKSSGRCILDS--------WRCD------------------GDA-DCKDGS--DEDPAVCFK 3782
              ...|.|...|.|        |..|                  ||| ...||:  .|.|
  Rat   200 YGVFSSPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGAGPPETP----- 259

  Fly  3783 RTCDPKTEFS----------------------CKNGR-----------CIPQLWMCDFDNDCGDD 3814
            |.....|.||                      ..|||           |:|  |    |..||..
  Rat   260 RLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP--W----DRPCGLG 318

  Fly  3815 SDEPAYMCRQRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKC-- 3877
            |...|.......|.:..||               |||..||.|.:||  |.||.| |...:.|
  Rat   319 SGLGASENLGERCYSEAQR---------------CDGSWDCADGTDE--EGCPGC-PPGHYPCGA 365

  Fly  3878 ----GNNRCIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDC 3938
                |...|......|::...|.|.:||.      |.|.|....|||.:.||:...|.||.:.||
  Rat   366 AGTPGATACYLPADRCNYQTFCADGADER------RCRHCQPGNFRCRDEKCVYETWVCDGQPDC 424

  Fly  3939 GDNSDEMHC 3947
            .|.|||..|
  Rat   425 TDGSDEWDC 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mgl	NP_572563.3	LDLa	157..189	CDD:238060
		LDLa	204..236	CDD:238060
		LDLa	292..327	CDD:238060
		LDLa	332..366	CDD:238060
		LDLa	371..412	CDD:238060
		vWFA	<447..488	CDD:469594
		YncE	<492..634	CDD:442618
		NHL	573..>716	CDD:302697
		NHL repeat	573..610	CDD:271320
		NHL repeat	616..654	CDD:271320
		NHL repeat	657..693	CDD:271320
		FXa_inhibition	763..805	CDD:464251
		YvrE	854..>992	CDD:442613
		LY	922..964	CDD:214531
		LY	973..1007	CDD:214531
		Ldl_recept_a	1188..1223	CDD:395011
		LDLa	1227..1259	CDD:197566
		LDLa	1268..1303	CDD:238060
		LDLa	1308..1343	CDD:238060
		LDLa	1356..1387	CDD:238060
		LDLa	1391..1423	CDD:197566
		LDLa	1435..1469	CDD:197566
		FXa_inhibition	1522..1553	CDD:464251
		LY	1625..1665	CDD:214531
		LY	1667..1711	CDD:214531
		Ldl_recept_b	1690..1729	CDD:459654
		LY	1712..1754	CDD:214531
		LY	1986..2037	CDD:214531
		FXa_inhibition	2151..>2179	CDD:464251
		LY	2259..2305	CDD:214531
		Ldl_recept_b	2326..2366	CDD:459654
		LY	2352..2392	CDD:214531
		NHL	2579..>2711	CDD:302697
		NHL repeat	2593..2622	CDD:271320
		NHL repeat	2634..2678	CDD:271320
		LY	2671..2713	CDD:214531
		LDLa	2867..2901	CDD:238060
		LDLa	2906..2941	CDD:238060
		LDLa	2950..2983	CDD:238060
		LDLa	3034..3066	CDD:197566
		LDLa	3080..3115	CDD:197566
		LDLa	3128..3159	CDD:238060
		LDLa	3170..3204	CDD:238060
		LDLa	3210..3242	CDD:197566
		FXa_inhibition	3259..3287	CDD:464251
		FXa_inhibition	3293..3329	CDD:464251
		LY	3362..3394	CDD:214531
		LY	3406..3448	CDD:214531
		Ldl_recept_b	3468..3511	CDD:459654
		LY	3498..3536	CDD:214531
		LY	3536..3578	CDD:214531
		FXa_inhibition	3607..3659	CDD:464251	10/47 (21%)
		LDLa	3663..3696	CDD:238060	7/36 (19%)
		LDLa	3705..3739	CDD:238060	18/33 (55%)
		LDLa	3743..3775	CDD:197566	15/69 (22%)
		LDLa	3784..3817	CDD:197566	13/65 (20%)
		LDLa	3827..3861	CDD:197566	9/33 (27%)
		LDLa	3871..3901	CDD:197566	7/35 (20%)
		LDLa	3913..3947	CDD:238060	15/33 (45%)
		LDLa	3952..3986	CDD:238060
		LDLa	3996..4027	CDD:197566
		LDLa	4043..4071	CDD:238060
		LDLa	4086..4117	CDD:238060
		EGF_CA	4163..4194	CDD:214542
NHL	4276..>4426	CDD:302697
NHL repeat	4291..4336	CDD:271320
Ldl_recept_b	4350..4391	CDD:459654
LY	4374..4417	CDD:214531
NHL repeat	4376..4422	CDD:271320
Lrp10	NP_001382489.1	CUB	36..136	CDD:412131	17/114 (15%)
		LDLa	142..176	CDD:238060	18/33 (55%)
		CUB	192..302	CDD:238001	23/114 (20%)
		LDLa	<330..353	CDD:238060	12/39 (31%)
		LDLa	399..433	CDD:238060	15/33 (45%)