| Sequence 1: | NP_001096924.2 | Gene: | mgl / 8674055 | FlyBaseID: | FBgn0261260 | Length: | 4769 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_786938.2 | Gene: | Ldlr / 300438 | RGDID: | 2998 | Length: | 879 | Species: | Rattus norvegicus |
| Alignment Length: | 943 | Identity: | 293/943 - (31%) |
|---|---|---|---|
| Similarity: | 418/943 - (44%) | Gaps: | 197/943 - (20%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 2824 NTCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNN--GRCIFKSWKC 2886
Fly 2887 DHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCP 2951
Fly 2952 ANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDD 3016
Fly 3017 CGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEET 3081
Fly 3082 EFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQPCGEDMFTCGNGRCINKGWI 3146
Fly 3147 CDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRNQSRCDGEDDCGDHSDEVGCAKENITC 3211
Fly 3212 PQG--QFACTNGQCIDYNLVCNKYPDCADESDEP-AHCNVDECAKVEIN-QCGHKCVDTLTGYYC 3272
Fly 3273 DCNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCDETYYERQNDEHT--CKRKDKI 3335
Fly 3336 PPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDE 3400
Fly 3401 MPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVDPRAIVVH 3464
Fly 3465 PGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYA 3529
Fly 3530 DLEGRHRHTVLSGSK-VPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLH 3593
Fly 3594 INHPLRQLPYTNPCGTN--------NGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQF 3650
Fly 3651 YLARDMKTCVAN-----CTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPRHCRAGTF 3710
Fly 3711 QCKNTNCTP------SATICDGVD-DCGDRSDE 3736 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| mgl | NP_001096924.2 | LDLa | 157..189 | CDD:238060 | |
| LDLa | 204..236 | CDD:238060 | |||
| LDLa | 292..327 | CDD:238060 | |||
| LDLa | 332..366 | CDD:238060 | |||
| LDLa | 371..412 | CDD:238060 | |||
| vWFA | <447..488 | CDD:294047 | |||
| NHL | 573..>716 | CDD:302697 | |||
| NHL repeat | 573..610 | CDD:271320 | |||
| NHL repeat | 616..654 | CDD:271320 | |||
| NHL repeat | 657..693 | CDD:271320 | |||
| FXa_inhibition | 763..805 | CDD:291342 | |||
| LY | 922..964 | CDD:214531 | |||
| LY | 973..1007 | CDD:214531 | |||
| Ldl_recept_a | 1188..1223 | CDD:278486 | |||
| LDLa | 1227..1259 | CDD:197566 | |||
| LDLa | 1268..1303 | CDD:238060 | |||
| LDLa | 1308..1343 | CDD:238060 | |||
| LDLa | 1356..1387 | CDD:238060 | |||
| LDLa | 1391..1423 | CDD:197566 | |||
| LDLa | 1435..1469 | CDD:197566 | |||
| FXa_inhibition | 1478..1513 | CDD:291342 | |||
| FXa_inhibition | 1522..1553 | CDD:291342 | |||
| LY | 1625..1665 | CDD:214531 | |||
| LY | 1667..1711 | CDD:214531 | |||
| Ldl_recept_b | 1690..1728 | CDD:278487 | |||
| LY | 1712..1754 | CDD:214531 | |||
| LY | 1986..2037 | CDD:214531 | |||
| FXa_inhibition | 2151..>2179 | CDD:291342 | |||
| LY | 2259..2305 | CDD:214531 | |||
| Ldl_recept_b | 2326..2366 | CDD:278487 | |||
| LY | 2352..2392 | CDD:214531 | |||
| NHL | 2579..>2711 | CDD:302697 | |||
| NHL repeat | 2593..2622 | CDD:271320 | |||
| NHL repeat | 2634..2678 | CDD:271320 | |||
| LY | 2671..2713 | CDD:214531 | |||
| LDLa | 2867..2901 | CDD:238060 | 18/35 (51%) | ||
| LDLa | 2906..2941 | CDD:238060 | 7/34 (21%) | ||
| LDLa | 2950..2983 | CDD:238060 | 8/32 (25%) | ||
| LDLa | 3034..3066 | CDD:197566 | 2/31 (6%) | ||
| LDLa | 3080..3115 | CDD:197566 | 2/34 (6%) | ||
| LDLa | 3128..3159 | CDD:238060 | 12/30 (40%) | ||
| LDLa | 3170..3204 | CDD:238060 | 15/33 (45%) | ||
| LDLa | 3210..3242 | CDD:197566 | 14/33 (42%) | ||
| cEGF | 3269..3292 | CDD:289433 | 10/22 (45%) | ||
| vWFA | <3284..3324 | CDD:294047 | 16/39 (41%) | ||
| LY | 3362..3394 | CDD:214531 | 11/31 (35%) | ||
| LY | 3406..3448 | CDD:214531 | 13/41 (32%) | ||
| LY | 3498..3536 | CDD:214531 | 13/37 (35%) | ||
| LY | 3536..3578 | CDD:214531 | 16/42 (38%) | ||
| FXa_inhibition | 3607..3659 | CDD:291342 | 21/59 (36%) | ||
| LDLa | 3663..3696 | CDD:238060 | 4/32 (13%) | ||
| LDLa | 3705..3739 | CDD:238060 | 10/39 (26%) | ||
| LDLa | 3743..3775 | CDD:197566 | |||
| LDLa | 3784..3817 | CDD:197566 | |||
| LDLa | 3827..3861 | CDD:197566 | |||
| LDLa | 3871..3901 | CDD:197566 | |||
| LDLa | 3913..3947 | CDD:238060 | |||
| LDLa | 3952..3986 | CDD:238060 | |||
| LDLa | 3996..4027 | CDD:197566 | |||
| LDLa | 4043..4071 | CDD:238060 | |||
| LDLa | 4086..4117 | CDD:238060 | |||
| EGF_CA | 4163..4194 | CDD:214542 | |||
| NHL | 4276..>4426 | CDD:302697 | |||
| NHL repeat | 4291..4336 | CDD:271320 | |||
| Ldl_recept_b | 4350..4390 | CDD:278487 | |||
| NHL repeat | 4376..4422 | CDD:271320 | |||
| Ldlr | NP_786938.2 | Ldl_recept_a | 25..58 | CDD:395011 | 13/32 (41%) |
| Ldl_recept_a | 66..104 | CDD:395011 | 18/37 (49%) | ||
| Ldl_recept_a | 107..143 | CDD:395011 | 16/82 (20%) | ||
| Ldl_recept_a | 196..232 | CDD:395011 | 15/38 (39%) | ||
| Ldl_recept_a | 235..271 | CDD:395011 | 16/35 (46%) | ||
| Ldl_recept_a | 279..309 | CDD:395011 | 13/29 (45%) | ||
| FXa_inhibition | 319..353 | CDD:405372 | 14/36 (39%) | ||
| EGF_CA | 355..389 | CDD:214542 | 15/37 (41%) | ||
| LDL-receptor class B 1 | 398..439 | 17/41 (41%) | |||
| NHL | <435..628 | CDD:302697 | 62/197 (31%) | ||
| NHL repeat | 435..469 | CDD:271320 | 6/36 (17%) | ||
| LDL-receptor class B 2 | 440..485 | 13/47 (28%) | |||
| NHL repeat | 476..514 | CDD:271320 | 12/37 (32%) | ||
| LDL-receptor class B 3 | 486..528 | 16/41 (39%) | |||
| LDL-receptor class B 4 | 529..572 | 14/44 (32%) | |||
| Ldl_recept_b | 529..569 | CDD:395012 | 13/41 (32%) | ||
| NHL repeat | 555..600 | CDD:271320 | 15/46 (33%) | ||
| LDL-receptor class B 5 | 573..615 | 15/41 (37%) | |||
| NHL repeat | 606..628 | CDD:271320 | 7/21 (33%) | ||
| LDL-receptor class B 6 | 616..658 | 12/41 (29%) | |||
| Ldl_recept_b | 616..655 | CDD:395012 | 11/38 (29%) | ||
| FXa_inhibition | 674..711 | CDD:405372 | 19/47 (40%) | ||
| Clustered O-linked oligosaccharides | 717..788 | 10/70 (14%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 718..797 | 12/78 (15%) | |||
| Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 | 830..879 | ||||
| NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 | 842..847 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.810 | |||||