DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and Lrp5

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_001099791.2 Gene:Lrp5 / 293649 RGDID:1309329 Length:1600 Species:Rattus norvegicus


Alignment Length:1440 Identity:436/1440 - (30%)
Similarity:685/1440 - (47%) Gaps:150/1440 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  1553 CKAVNHTAA-FLIISNRHSILVADLKEQGLERVPII--VENVVATASNMHTGTIFWSDMKLKKIS 1614
            |..|...|: .|:.:||..:.:.|.....||...:.  :|:..|.......|.::|:|:..:.|.
  Rat    24 CSLVPAAASPLLLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIK 88

  Fly  1615 RL---DRGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQP 1676
            :.   ..|...|.|:.:||...:|||.||:.:.|||.||:.|.|||:..||::|.||..:::.||
  Rat    89 QTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQP 153

  Fly  1677 RGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADSKL 1741
            |.:.:||:.|  :::||||||.||:||.||||:.||.|:::.||||||||:|:..:::|:||:||
  Rat   154 RAIALDPAHG--YMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKL 216

  Fly  1742 DFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLIS 1806
            .||.....:|:.||:|:..|  |.||.:|:|..|||||||.|...:.:.||:.|:.:..:...:.
  Rat   217 SFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILSALY 279

  Fly  1807 QPLSIHVHHASLQPMTPNPC--AGSRCQHLCLLSPSAPEGYSCKCRPGFKLLSEGR-CIEEENPF 1868
            .|:.|.|.....||....||  ....|.|||||||..| .|||.|..|.:|...|: |.......
  Rat   280 SPMDIQVLSQERQPPFHTPCEEGNGGCSHLCLLSPREP-FYSCACPTGVQLQDNGKTCKAGAEEV 343

  Fly  1869 LMVVKGTQI----------VDLPLNGGDARAGALAPVIGIESSTGLDFDRKGETLYWVQGREDDD 1923
            |::.:.|.:          .|:.|..||           |..:..:|:|.....:||.    ||:
  Rat   344 LLLARRTDLRRISLDTPDFTDIVLQVGD-----------IRHAIAIDYDPLEGYVYWT----DDE 393

  Fly  1924 ENCTIYTTPYGGGNKTLFLGIENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAVRVDGKQKYRTI 1988
            ..........|.|.:||.    |..:..|..||.||:.||||..:.....||..|::|..  |.|
  Rat   394 VRAIRRAYLDGSGAQTLV----NTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTS--RKI 452

  Fly  1989 ILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQN-PIVVFQEFAHPESLA 2052
            :::.|     :..|:.|.|.|..|.::|.|.|  |.| ||...:::|:: .::|......|..||
  Rat   453 LVSED-----LDEPRAIVLHPVMGLMYWTDWG--ENP-KIECANLDGRDRHVLVNTSLGWPNGLA 509

  Fly  2053 VDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPRSLG--ILDHRLYYLDPLYERIV 2115
            :|.::..:|:..:....|.|::.:|.... .|::|.    .|...|  :|...:|:.|.....|.
  Rat   510 LDLQEGKLYWGDAKTDKIEVINIDGTKRQ-TLLEDK----LPHIFGFTLLGDFIYWTDWQRRSIE 569

  Fly  2116 RIDLPHGDNPKTIVDNESDLRSM-MIYKKRALMQHPCQTNNGGCKHLCIPGPGATRTCACGIGYR 2179
            |:....... ..|:|...||..: .:...:.:..:||...||||.|||...|.||: |.|.||..
  Rat   570 RVHKVKASR-DVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSHLCFFTPHATK-CGCPIGLE 632

  Fly  2180 KENEI-NCVAYKIFAVVSQLDMIRGYSL-SDSSEAMVPISGPGH-HILHVDVMYREQWIYWAEYN 2241
            ..::: .|:..:.|.|.:....|...|| :::::..:|::|... ..|..||  ....|||.:.:
  Rat   633 LLSDMKTCIIPEAFLVFTSRATIHRISLETNNNDVAIPLTGVKEASALDFDV--SNNHIYWTDVS 695

  Fly  2242 RGYWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRK 2306
               ...|.|:..||:.::||::.|:  :...|:.:||:..|:|:.:.  ..|.:||..|||..|:
  Rat   696 ---LKTISRAFMNGSSVEHVIEFGL--DYPEGMAVDWMGKNLYWADT--GTNRIEVARLDGQFRQ 753

  Fly  2307 VLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHD 2371
            |||....|.||.||::|.|..:||.::|..|||.:|.:||:....||.. :....|||||.....
  Rat   754 VLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQR 817

  Fly  2372 IYWVDSKLDTIQKISYNGANRKIIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSANETATS 2436
            :||.|...:.|:..:..|..|.:|..|||.|.|:..|.:.:||.|.||.::.:|.| ::....|.
  Rat   818 LYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSDYIYWTDWNLHSIERADK-TSGRNRTL 881

  Fly  2437 VRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCECATG- 2500
            ::.:|:.:.||.::  ::..||..|.|.| .||.|.|||.:.|         ||.  ||.||:. 
  Rat   882 IQGHLDFVMDILVF--HSSRQDGLNDCVH-SNGQCGQLCLAIP---------GGH--RCGCASHY 932

  Fly  2501 KLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNVVGLDFDFAHNRMLYTQIR 2565
            .|....|.|...:.:|:|:.:..|..:..|...:.....||..|.||..:::|            
  Rat   933 TLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLILPLHGLRNVKAINYD------------ 985

  Fly  2566 PWAKIAY---TKAN-KPGHDDIT---------VVLNKGINPEGIAYDWTQQKIYWTDSSNNSIYA 2617
            |..|..|   .:.| |...||.|         ..|:....|..::.|...:.::||..:.|:|..
  Rat   986 PLDKFIYWVDGRQNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINV 1050

  Fly  2618 MNLDGSELVMIAR--VERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQ 2680
            ..|||..:.::.|  .:|||||.::...|.::||:..  ..:.||.|.::.|:.:..:....|.:
  Rat  1051 HRLDGDAMGVVLRGDRDRPRAIAVNAERGYMYFTNMQ--DHAAKIERASLDGTEREVLFTTGLIR 1113

  Fly  2681 PSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATI-YPFAITVFRNYIYWTDLQLRGVY 2744
            |..|.:|....:|:|.||..::||..||.|.||..|..|.| .|..:||...::||.|.|.:.:.
  Rat  1114 PVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPVGLTVLGRHLYWIDRQQQMIE 1178

  Fly  2745 RAEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDS 2809
            |.||.||.....:..|:........:.....::.:.:||..:||||:..|....:|...|.|...
  Rat  1179 RVEKTTGDKRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVH 1243

  Fly  2810 TKVVNEGRMCAPRNNTCEASKFYCKNGR--CISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEF 2872
            ..::.....|. ...||...:|.|..|.  ||...|.|||..:|.|.|||:.  |..  ||.::|
  Rat  1244 LVLLQNLLTCG-EPPTCSPDQFACATGEIDCIPGAWRCDGFPECADQSDEEG--CPV--CSASQF 1303

  Fly  2873 RCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATS 2937
            .|..|:|:....:||                ..|:..:|.||:|:|:...|.|:...||.|.  |
  Rat  1304 PCARGQCVDLRLRCD----------------AVCLPNQFRCASGQCVLIKQQCDSFPDCADG--S 1350

  Fly  2938 DETHERCPMN 2947
            ||.  .|.:|
  Rat  1351 DEL--MCEIN 1358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342 436/1440 (30%)
LY 1625..1665 CDD:214531 19/39 (49%)
LY 1667..1711 CDD:214531 22/43 (51%)
Ldl_recept_b 1690..1728 CDD:278487 25/37 (68%)
LY 1712..1754 CDD:214531 19/41 (46%)
LY 1986..2037 CDD:214531 16/50 (32%)
FXa_inhibition 2151..>2179 CDD:291342 15/27 (56%)
LY 2259..2305 CDD:214531 14/45 (31%)
Ldl_recept_b 2326..2366 CDD:278487 14/39 (36%)
LY 2352..2392 CDD:214531 12/39 (31%)
NHL 2579..>2711 CDD:302697 38/142 (27%)
NHL repeat 2593..2622 CDD:271320 7/28 (25%)
NHL repeat 2634..2678 CDD:271320 11/43 (26%)
LY 2671..2713 CDD:214531 13/41 (32%)
LDLa 2867..2901 CDD:238060 8/33 (24%)
LDLa 2906..2941 CDD:238060 14/34 (41%)
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
Lrp5NP_001099791.2 NHL <37..>169 CDD:302697 42/133 (32%)
NHL repeat 65..104 CDD:271320 8/38 (21%)
LY 102..142 CDD:214531 19/39 (49%)
NHL repeat 107..148 CDD:271320 20/40 (50%)
Ldl_recept_b 163..203 CDD:278487 26/41 (63%)
LY 187..229 CDD:214531 19/41 (46%)
LY 230..271 CDD:214531 19/42 (45%)
FXa_inhibition 299..336 CDD:291342 17/37 (46%)
LY 366..406 CDD:214531 11/54 (20%)
LY 408..450 CDD:214531 16/47 (34%)
LY 451..494 CDD:214531 15/50 (30%)
LY 495..537 CDD:214531 9/41 (22%)
LY 538..571 CDD:214531 8/37 (22%)
FXa_inhibition 605..640 CDD:291342 15/35 (43%)
NHL 685..878 CDD:302697 68/201 (34%)
LY 710..752 CDD:214531 14/45 (31%)
NHL repeat 720..756 CDD:271320 13/37 (35%)
NHL repeat 763..802 CDD:271320 17/38 (45%)
NHL repeat 808..843 CDD:271320 12/34 (35%)
NHL repeat 847..871 CDD:271320 8/23 (35%)
FXa_inhibition 906..941 CDD:291342 17/46 (37%)
LY 1060..1103 CDD:214531 13/44 (30%)
LY 1104..1146 CDD:214531 13/41 (32%)
FXa_inhibition 1217..1253 CDD:291342 9/35 (26%)
LDLa 1259..1295 CDD:238060 15/37 (41%)
LDLa 1321..1355 CDD:238060 14/37 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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