Protein Alignment mgl and LRP10

DIOPT Version :10

• Sequence 1: NP_572563.3
• Gene: mgl / 8674055
• FlyBaseID: FBgn0261260
• Length: 4769
• Species: Drosophila melanogaster
• Sequence 2: XP_005267567.1
• Gene: LRP10 / 26020
• HGNCID: 14553
• Length: 721
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 116/468 - (24%)
• Similarity: 142/468 - (30%)
• Gaps: 186/468 - (39%)

  Fly  3615 SHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDEKCIP 3679
            :|.|   ..|.:..|.::|.::..             |.||.:|..||||  ..:.|.:::....
Human    25 NHAC---EDPPAVLLEVQGTLQRP-------------LVRDSRTSPANCT--WLILGSKEQTVTI 71

  Fly  3680 WFWK----CDGEKDCKDGSDEP--ATC-------------------------------------A 3701
            .|.|    |..|:.......:|  :.|                                     |
Human    72 RFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQA 136

  Fly  3702 PRH--------CRAGTFQCKNTNCTPSATICDGVDDCGDRSDEQNC--------------DLPC- 3743
            |.|        |....|||.|..|..:...|||||.|||.|||..|              .|||
Human   137 PLHGASADWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCN 201

  Fly  3744 -PLSDF--KCKSSGRCILDS--------WRCD------------------GDA-DCKDGSDEDPA 3778
             .|.||  ...|.|...|.|        |..|                  ||| ...||.....:
Human   202 VTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPES 266

  Fly  3779 VCFKRTCDPKTEFS----------------------CKNGR-----------CIPQLWMCDFDND 3810
               .|.....|.||                      ..|||           |:|  |    |..
Human   267 ---SRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP--W----DRP 322

  Fly  3811 CGDDSDEPAYMCRQRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDF 3875
            ||..|...|.......|.:..||               |||..||.|.:||  |:||.| |...|
Human   323 CGLGSGLGAGEGLGERCYSEAQR---------------CDGSWDCADGTDE--EDCPGC-PPGHF 369

  Fly  3876 KC------GNNRCIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDH 3934
            .|      |...|......|::...|.|.:||.      |.|.|....|||.:.||:...|.||.
Human   370 PCGAAGTSGATACYLPADRCNYQTFCADGADER------RCRHCQPGNFRCRDEKCVYETWVCDG 428

  Fly  3935 EDDCGDNSDEMHC 3947
            :.||.|.|||..|
Human   429 QPDCADGSDEWDC 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mgl	NP_572563.3	LDLa	157..189	CDD:238060
		LDLa	204..236	CDD:238060
		LDLa	292..327	CDD:238060
		LDLa	332..366	CDD:238060
		LDLa	371..412	CDD:238060
		vWFA	<447..488	CDD:469594
		YncE	<492..634	CDD:442618
		NHL	573..>716	CDD:302697
		NHL repeat	573..610	CDD:271320
		NHL repeat	616..654	CDD:271320
		NHL repeat	657..693	CDD:271320
		FXa_inhibition	763..805	CDD:464251
		YvrE	854..>992	CDD:442613
		LY	922..964	CDD:214531
		LY	973..1007	CDD:214531
		Ldl_recept_a	1188..1223	CDD:395011
		LDLa	1227..1259	CDD:197566
		LDLa	1268..1303	CDD:238060
		LDLa	1308..1343	CDD:238060
		LDLa	1356..1387	CDD:238060
		LDLa	1391..1423	CDD:197566
		LDLa	1435..1469	CDD:197566
		FXa_inhibition	1522..1553	CDD:464251
		LY	1625..1665	CDD:214531
		LY	1667..1711	CDD:214531
		Ldl_recept_b	1690..1729	CDD:459654
		LY	1712..1754	CDD:214531
		LY	1986..2037	CDD:214531
		FXa_inhibition	2151..>2179	CDD:464251
		LY	2259..2305	CDD:214531
		Ldl_recept_b	2326..2366	CDD:459654
		LY	2352..2392	CDD:214531
		NHL	2579..>2711	CDD:302697
		NHL repeat	2593..2622	CDD:271320
		NHL repeat	2634..2678	CDD:271320
		LY	2671..2713	CDD:214531
		LDLa	2867..2901	CDD:238060
		LDLa	2906..2941	CDD:238060
		LDLa	2950..2983	CDD:238060
		LDLa	3034..3066	CDD:197566
		LDLa	3080..3115	CDD:197566
		LDLa	3128..3159	CDD:238060
		LDLa	3170..3204	CDD:238060
		LDLa	3210..3242	CDD:197566
		FXa_inhibition	3259..3287	CDD:464251
		FXa_inhibition	3293..3329	CDD:464251
		LY	3362..3394	CDD:214531
		LY	3406..3448	CDD:214531
		Ldl_recept_b	3468..3511	CDD:459654
		LY	3498..3536	CDD:214531
		LY	3536..3578	CDD:214531
		FXa_inhibition	3607..3659	CDD:464251	8/43 (19%)
		LDLa	3663..3696	CDD:238060	7/36 (19%)
		LDLa	3705..3739	CDD:238060	17/33 (52%)
		LDLa	3743..3775	CDD:197566	15/62 (24%)
		LDLa	3784..3817	CDD:197566	13/65 (20%)
		LDLa	3827..3861	CDD:197566	9/33 (27%)
		LDLa	3871..3901	CDD:197566	8/35 (23%)
		LDLa	3913..3947	CDD:238060	15/33 (45%)
		LDLa	3952..3986	CDD:238060
		LDLa	3996..4027	CDD:197566
		LDLa	4043..4071	CDD:238060
		LDLa	4086..4117	CDD:238060
		EGF_CA	4163..4194	CDD:214542
NHL	4276..>4426	CDD:302697
NHL repeat	4291..4336	CDD:271320
Ldl_recept_b	4350..4391	CDD:459654
LY	4374..4417	CDD:214531
NHL repeat	4376..4422	CDD:271320
LRP10	XP_005267567.1	CUB	34..134	CDD:238001	17/114 (15%)
		LDLa	148..182	CDD:238060	17/33 (52%)
		CUB	200..310	CDD:238001	22/112 (20%)
		LDLa	<338..361	CDD:238060	12/39 (31%)
		LDLa	407..441	CDD:238060	15/33 (45%)
		PRK04654	<581..683	CDD:135173