DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and Vldlr

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_037287.2 Gene:Vldlr / 25696 RGDID:3963 Length:873 Species:Rattus norvegicus


Alignment Length:822 Identity:306/822 - (37%)
Similarity:418/822 - (50%) Gaps:124/822 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  2867 CSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDC 2931
            |..::|:|.|||||...||||.:.||.|||||..||...|.:.:|.|.||:|:|..         
  Rat    33 CDSSQFQCTNGRCITLLWKCDGDEDCTDGSDEKNCVKKTCAESDFVCKNGQCVPNR--------- 88

  Fly  2932 KDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNS 2996
                                                |.||||.||.|.|||.|..|..|||..|.
  Rat    89 ------------------------------------WQCDGDPDCEDGSDESPEQCHMRTCRINE 117

  Fly  2997 FRC--PNHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDND 3059
            ..|  .:.:|||.:|.|||::||.:|.||  :.|.:  .||..|.|||.:|.|:.|.::|:|.:|
  Rat   118 ISCGARSTQCIPESWRCDGENDCDNGEDE--ENCGN--ITCSADEFTCSSGRCVSRNFVCNGQDD 178

  Fly  3060 CLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCAT 3124
            |.|.|||   ..|....|... ||.|      ..:.|||..|:||.|.||.|.:||  :|..|. 
  Rat   179 CDDGSDE---LDCAPPTCGAH-EFQC------STSSCIPLSWVCDDDADCSDQSDE--SLEQCG- 230

  Fly  3125 QQP-----CGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIR 3184
            :||     |......||:|.||:|.|.||.|.||.||:||   .|...:||...:|.|::..||.
  Rat   231 RQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDE---VNCPSRTCRPDQFECEDGSCIH 292

  Fly  3185 NQSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDEP-AHCNV 3248
            ...:|:|..||.|.||||.|...|.....|:|.|.:|:|||...||::..||.|.|||| ..|::
  Rat   293 GSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDITKVCDQEQDCRDWSDEPLKECHI 357

  Fly  3249 DECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYC 3313
            :||. |....|.|.|.|.:.||.|||..|::|: |.|.|.|:||| :.||.|||.|.|..||:.|
  Rat   358 NECL-VNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDEC-QNPGICSQICINLKGGYKC 419

  Fly  3314 KCDETYYERQNDEHT--CKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIRE 3376
            :|...|   |.|..|  ||...| .|.|||||:..:|.:.::..:|..:.:.|.|.||||.||..
  Rat   420 ECSRGY---QMDLATGVCKAVGK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480

  Fly  3377 EYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRH-----DSHGLEGIAIDWVGRKLYWLDRHSK 3436
            :.:::.|::.|.||.|   ..||:       |.||     :.:....||:|||.:.:||.|..||
  Rat   481 QKLFWADLSQKAIFSA---SIDDK-------VGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASK 535

  Fly  3437 NLDVSELDGSKRKTL-RSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDG 3500
            .:.|:.|||:|||.| .|.:.:|.:|.|.|..|::|::.|...|.|.|.||:|  |.|.....:.
  Rat   536 TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNG--FDRRPLVTED 598

  Fly  3501 IAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSK-VPHVFALSLFDDYIYWSDWN 3564
            |.|||.:::|....|:||.|:.|..::..||.|:.|..||...: :.|..||::|:|.:||.|..
  Rat   599 IQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGE 663

  Fly  3565 LKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQLPYTNPCGTN-------NGGCSHLCLIAP 3622
            .:|:..||||.|:....|.|..:...|:.|.|.|.|     |.|.|       ||||.:|||.||
  Rat   664 NEAVYGANKFTGSELATLVNNLNDAQDIIIYHELVQ-----PSGKNWCEEDMENGGCEYLCLPAP 723

  Fly  3623 PPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCVANCT 3664
                       .|.:.:|.:.|:|||.:.|..:.:.|.:..|
  Rat   724 -----------QINDHSPKYTCSCPNGYNLEENGRECQSTST 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 19/33 (58%)
LDLa 2906..2941 CDD:238060 7/34 (21%)
LDLa 2950..2983 CDD:238060 10/32 (31%)
LDLa 3034..3066 CDD:197566 15/31 (48%)
LDLa 3080..3115 CDD:197566 13/34 (38%)
LDLa 3128..3159 CDD:238060 15/30 (50%)
LDLa 3170..3204 CDD:238060 14/33 (42%)
LDLa 3210..3242 CDD:197566 13/31 (42%)
cEGF 3269..3292 CDD:289433 11/22 (50%)
vWFA <3284..3324 CDD:294047 18/39 (46%)
LY 3362..3394 CDD:214531 13/31 (42%)
LY 3406..3448 CDD:214531 17/46 (37%)
LY 3498..3536 CDD:214531 13/37 (35%)
LY 3536..3578 CDD:214531 17/42 (40%)
FXa_inhibition 3607..3659 CDD:291342 18/58 (31%)
LDLa 3663..3696 CDD:238060 1/2 (50%)
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
VldlrNP_037287.2 LDLa 33..67 CDD:238060 19/33 (58%)
LDLa 71..103 CDD:197566 16/76 (21%)
Ldl_recept_a 111..149 CDD:395011 17/39 (44%)
Ldl_recept_a 153..188 CDD:395011 17/37 (46%)
LDLa 192..224 CDD:197566 14/38 (37%)
Ldl_recept_a 237..273 CDD:395011 17/38 (45%)
Ldl_recept_a 276..312 CDD:395011 15/35 (43%)
Ldl_recept_a 320..350 CDD:395011 13/29 (45%)
FXa_inhibition 360..394 CDD:405372 15/35 (43%)
EGF_CA 396..426 CDD:214542 16/33 (48%)
LDL-receptor class B 1 439..480 17/41 (41%)
LY 461..499 CDD:214531 14/40 (35%)
LDL-receptor class B 2 481..524 14/52 (27%)
Ldl_recept_b 481..521 CDD:395012 12/49 (24%)
LY 508..547 CDD:214531 14/38 (37%)
LDL-receptor class B 3 525..567 18/41 (44%)
LDL-receptor class B 4 568..611 16/44 (36%)
Ldl_recept_b 568..608 CDD:395012 15/41 (37%)
LY 592..634 CDD:214531 13/41 (32%)
LDL-receptor class B 5 612..654 14/41 (34%)
LDL-receptor class B 6 655..697 15/41 (37%)
Ldl_recept_b 655..694 CDD:395012 13/38 (34%)
FXa_inhibition 706..749 CDD:405372 16/53 (30%)
Clustered O-linked oligosaccharides 751..790 1/4 (25%)
Endocytosis signal. /evidence=ECO:0000255 832..837
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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