DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and Sorl1

DIOPT Version :10

Sequence 1:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_035566.2 Gene:Sorl1 / 20660 MGIID:1202296 Length:2215 Species:Mus musculus


Alignment Length:1726 Identity:460/1726 - (26%)
Similarity:656/1726 - (38%) Gaps:478/1726 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  3257 NQC--GHK--------------------------CVDTLTGYYCDCNEGYKLLADGKACADVDEC 3293
            |:|  |||                          |..|...|.||.  |:|:..|    ..::.|
Mouse   641 NECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDF--GFKMSED----LSLEVC 699

  Fly  3294 LEQPGACSQHCSNTPGGFY-----CKCDETYYE----RQNDEHTCKRKD--------KIPPWLIF 3341
            :..|     ..|..|   |     |....:|..    |:....||...|        .:|..|..
Mouse   700 VPDP-----EFSGKP---YSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAE 756

  Fly  3342 TNKYYVRNMSVDGHQYNLMH--------QDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEAD 3398
            .|::.:..|....::|:|..        ..|...||||||.....:|:.|:...||.|.....:.
Mouse   757 ENEFILYAMRKSIYRYDLASGATEQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGST 821

  Fly  3399 DEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVD-PRAI 3461
            .:     |.:|......:|.:|.:.:.:.|||:|...|.::|:..||..|.|: .|.|:| |||:
Mouse   822 GQ-----EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRAL 881

  Fly  3462 VVHPGIGYLYFTSW-HLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDY 3525
            |:.|..|.:::|.| .|:..|.:..||||...|::  ::.:.|||.:|:|  :..|||.||:||.
Mouse   882 VLVPQEGVMFWTDWGDLKPGIYRSYMDGSAAYRLV--SEDVKWPNGISVD--SQWIYWTDAYLDC 942

  Fly  3526 IAYADLEGRHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPY 3590
            |......|:.|..:|  ..:||.:|:::|.:.|||.||:..:|.||:|...:...:|.:......
Mouse   943 IERITFSGQQRSVIL--DSLPHPYAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILASQLTGLM 1005

  Fly  3591 DLHINHPLRQLPYTNPCGTNNGG-------CSHLCLIAPPPESTYLNIEGYIEEGAPI--FKCAC 3646
            |:.:.:.          |.|.|.       ||.|||.......:....||......|.  ..|.|
Mouse  1006 DMKVFYK----------GKNAGSNACVPQPCSLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDC 1060

  Fly  3647 PNQFYLARDMKTCVA---NCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPRHCRAG 3708
            |..:  .|...|||.   .|...|:.|.  :..||...|.||.:.||.|.||| ..|....|.|.
Mouse  1061 PQGY--QRKNNTCVKEENTCLRNQYRCS--NGNCINSIWWCDFDNDCGDMSDE-RNCPTTVCDAD 1120

  Fly  3709 T-FQCKNT-NCTPSATICDGVDDCGDRSDEQNCDL-PCPLSDFKCKSSGRCILDSWRCDGDADCK 3770
            | |:|:.: .|.|.:..||..|||||.|||.:|:: .|...:|.| |||.||..||.||||.||:
Mouse  1121 TQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEFNC-SSGMCIRSSWVCDGDNDCR 1184

  Fly  3771 DGSDEDPAVCFKRTCDPKTEFSCKNGRCIPQLWMCDFDNDCGDDSDEPAYMCRQRNCTTGWQRCP 3835
            |.|||........||: .:.|.|.||.||||.|.||.|.||.|.|||....| ::.| .|: .||
Mouse  1185 DWSDEANCTAIYHTCE-ASNFQCHNGHCIPQRWACDGDADCQDGSDEDPVSC-EKKC-NGF-HCP 1245

  Fly  3836 GQSNYRCIPKWLFCDGKDDCRDNSDELPENC-PKCNPETDFKCGN-NRCIPKQWMCDFADDCGDA 3898
               |..|||....|||..||.|.|||  ::| |.|....||.|.| .:|:....:||....|.|.
Mouse  1246 ---NGTCIPSSKHCDGLRDCPDGSDE--QHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIVQCRDG 1305

  Fly  3899 SDENEAV--CKGR---YRECSESEFRCGNGKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGT-- 3956
            |||:.|.  |...   ::||.|..|:|.||.|||..|:||..|||||.|||.:||     |.|  
Mouse  1306 SDEDAAFAGCSQDPEFHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCE-----NPTEA 1365

  Fly  3957 --------FQCASGHCIASYFRCDGDRDCRDMSDEVGC------PPRFPGGRYCPESRFQCNNNL 4007
                    |.|.:||||.:.::||.:.||.|.|||..|      |...||...|..:.|.|::..
Mouse  1366 PNCSRYFQFHCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHVLPSPTPGPSTCLPNYFHCSSGA 1430

  Fly  4008 CVSLSDLCDGTDDCGDGSDED--PSVCSDFNCDTLRRF-QCSN--------ERCVARYQICDGVD 4061
            ||..:.:|||..||.|||||:  ||:.:.....|..:| ||..        ::|:..::.|||..
Mouse  1431 CVMGTWVCDGYRDCADGSDEEACPSLANSTAASTPTQFGQCDRFEFECHQPKKCIPNWKRCDGHQ 1495

  Fly  4062 NCGDGSDENN----MTL-CASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGDASDELGCHHTS 4121
            :|.||.||.|    .|| |.|::..|:       ..:.||..|:.||...||.|.|||..|....
Mouse  1496 DCQDGQDEANCPTHSTLTCTSREFKCE-------DGEACIVLSERCDGFLDCSDESDEKACSDEL 1553

  Fly  4122 SCSEANR-----------------------GGCQQHCHNLTDGGYICTCYPGYIIAADNKKKCSD 4163
            :..:...                       ..|..:.:....|..|      :.....:..|.|.
Mouse  1554 TVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESI------WKTLETHSNKTST 1612

  Fly  4164 VDECLTRQHT--------CSHQCHNLNGTYSCSCREGFHLTDGASGV---CRAEKEDVIL----- 4212
            |.:.|....|        |.::.||.|...:....||  |.|....:   ..:|:|.|||     
Mouse  1613 VLKVLKPDTTYQVKVQVHCLNKVHNTNDFVTLRTPEG--LPDAPRNLQLSLNSEEEGVILGHWAP 1675

  Fly  4213 ---------------------------LFVNGQEIRGL-------------------NWHKSEEF 4231
                                       ...|..||:.|                   ||..|:..
Mouse  1676 PVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSI 1740

  Fly  4232 AVIAAEKRIEA----------------LDYDAQQQI------VFWADSYD------KTIK----- 4263
            ..|.. |.|:|                |..|...::      :||  |:|      ||:.     
Mouse  1741 TTIKG-KVIQAPNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFW--SFDAHKQEKKTLSFRGGS 1802

  Fly  4264 ------------RSYMVNA---ID-GRAKIGFAQDLNMKGGSKP-----------TAVAVDWLAS 4301
                        .||.::|   .| |.:.:.|...|. :|.|.|           |||...|...
Mouse  1803 ALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILT-RGSSPPAPSLKAKAINQTAVECIWTGP 1866

  Fly  4302 --------------NLYWTEMDRTGSKPRGRVMVAKTDGRY----RRSIVNAGLE--------VP 4340
                          :||......|.|.....|:|:| |.:|    |..|...|..        :|
Mouse  1867 KNVVYGIFYATSFLDLYRNPKSVTTSLHNKTVIVSK-DEQYLFLVRVLIPYQGPSSDYVVVKMIP 1930

  Fly  4341 TS---------IAVNPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEMIR--------HPAGLT 4388
            .|         :.:......|.|.....:|..::.:....|      ::||        .....|
Mouse  1931 DSRLPPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVK------DLIRKTDRSYKVRSRNST 1989

  Fly  4389 IDYS--------QDHIIYWVDTKLNAIESMRADGSRRKAIVRGDQLRHPVSLDLFESN----MFW 4441
            ::||        :.|||.       .:.:|..|.|.:...|   .|..|.:|.:...|    :||
Mouse  1990 VEYSLSKLEPGGKYHIIV-------QLGNMSKDSSIKITTV---SLSAPDALKIITENDHVLLFW 2044

  Fly  4442 MTRDTGELVRQDKFGRGVQVVLHRYIVNPSGLKVYHDKRYNTSLPNPCDN-STCSHLCLLVPGGH 4505
            .:....|  :|....||.::.:....||   |..|        |.|..|| ...|:|.:    ||
Mouse  2045 KSLALKE--KQFNETRGYEIHMSDSAVN---LTAY--------LGNTTDNFFKVSNLKM----GH 2092

  Fly  4506 RCACPDASGPPPSHRSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELLCECRTQFVGEHC 4570
                        ::..|.:..|...::               :|.|.|  .||.:          
Mouse  2093 ------------NYTFTVQARCLFGSQ---------------ICGEPA--VLLYD---------- 2118

  Fly  4571 ETSTMGAFGHGDA---------NVTAVVVPIMVILLVMMAAAGAWYVIRKR----PFGKLARMPA 4622
            |.|: ||    ||         :|.||||||:.::|:.:....|....:.|    .|...|....
Mouse  2119 ELSS-GA----DAAVIQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFSAFANSHY 2178

  Fly  4623 MTSSQSVTFRHGSNVEFNESGFPGASAPGAGDVAPI 4658
            .:...|..|..|.::..::...|  ...|..|..|:
Mouse  2179 SSRLGSAIFSSGDDLGEDDEDAP--MITGFSDDVPM 2212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:395011
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1522..1553 CDD:464251
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1729 CDD:459654
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:464251
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:459654
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
FXa_inhibition 3259..3287 CDD:464251 12/55 (22%)
FXa_inhibition 3293..3329 CDD:464251 8/44 (18%)
LY 3362..3394 CDD:214531 12/31 (39%)
LY 3406..3448 CDD:214531 12/41 (29%)
Ldl_recept_b 3468..3511 CDD:459654 14/43 (33%)
LY 3498..3536 CDD:214531 14/37 (38%)
LY 3536..3578 CDD:214531 15/41 (37%)
FXa_inhibition 3607..3659 CDD:464251 15/60 (25%)
LDLa 3663..3696 CDD:238060 12/32 (38%)
LDLa 3705..3739 CDD:238060 17/35 (49%)
LDLa 3743..3775 CDD:197566 18/31 (58%)
LDLa 3784..3817 CDD:197566 18/32 (56%)
LDLa 3827..3861 CDD:197566 15/33 (45%)
LDLa 3871..3901 CDD:197566 10/30 (33%)
LDLa 3913..3947 CDD:238060 20/33 (61%)
LDLa 3952..3986 CDD:238060 16/43 (37%)
LDLa 3996..4027 CDD:197566 13/30 (43%)
LDLa 4043..4071 CDD:238060 12/36 (33%)
LDLa 4086..4117 CDD:238060 11/30 (37%)
EGF_CA 4163..4194 CDD:214542 9/38 (24%)
NHL 4276..>4426 CDD:302697 39/211 (18%)
NHL repeat 4291..4336 CDD:271320 16/73 (22%)
Ldl_recept_b 4350..4391 CDD:459654 7/48 (15%)
LY 4374..4417 CDD:214531 11/58 (19%)
NHL repeat 4376..4422 CDD:271320 11/61 (18%)
Sorl1NP_035566.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..84
VPS10 124..753 CDD:214740 25/125 (20%)
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
LY 780..821 CDD:214531 12/40 (30%)
LDL-receptor class B 1 800..843 9/47 (19%)
LY 824..866 CDD:214531 12/41 (29%)
LDL-receptor class B 2 844..887 18/42 (43%)
LY 868..910 CDD:214531 16/41 (39%)
LDL-receptor class B 3 888..932 15/47 (32%)
Ldl_recept_b 890..929 CDD:459654 13/40 (33%)
LY 913..953 CDD:214531 15/43 (35%)
LDL-receptor class B 4 933..972 15/40 (38%)
LY 953..987 CDD:214531 13/35 (37%)
LDL-receptor class B 5 973..1013 11/49 (22%)
LDLa 1078..1112 CDD:238060 14/36 (39%)
LDLa 1117..1153 CDD:238060 17/35 (49%)
Ldl_recept_a 1157..1192 CDD:395011 20/35 (57%)
Ldl_recept_a 1198..1230 CDD:395011 18/32 (56%)
LDLa 1240..1271 CDD:238060 16/36 (44%)
LDLa 1281..1308 CDD:197566 9/26 (35%)
LDLa 1325..1359 CDD:238060 20/33 (61%)
LDLa 1373..1403 CDD:238060 14/29 (48%)
LDLa 1419..1453 CDD:238060 15/33 (45%)
LDLa 1471..1506 CDD:238060 10/34 (29%)
LDLa 1514..1549 CDD:238060 14/41 (34%)
FN3 1557..1630 CDD:238020 8/78 (10%)
FN3 1651..1742 CDD:238020 13/90 (14%)
FN3 1690..>2100 CDD:442628 86/459 (19%)
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250|UniProtKB:Q92673 2162..2165 0/2 (0%)
Endocytosis signal. /evidence=ECO:0000255 2173..2178 1/4 (25%)
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250|UniProtKB:Q92673 2191..2215 4/24 (17%)
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250|UniProtKB:Q92673 2202..2215 3/11 (27%)
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250|UniProtKB:Q92673 2209..2213 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

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