DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and EGF

DIOPT Version :10

Sequence 1:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_001954.2 Gene:EGF / 1950 HGNCID:3229 Length:1207 Species:Homo sapiens


Alignment Length:1543 Identity:314/1543 - (20%)
Similarity:495/1543 - (32%) Gaps:626/1543 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  2497 CATGKLSAD-ERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNVVGLDFDFAHNRML 2560
            |..|.|:.: ...|.....:|:|:....|  ..:|...|......:....:|: :||.:...|:.
Human    28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSI--FRIDTEGTNYEQLVVDAGVSVI-MDFHYNEKRIY 89

  Fly  2561 YTQI-RPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGSE 2624
            :..: |...:..:...::...     |.|...|..|:|.:|..:::.|::.....|...::.|:.
Human    90 WVDLERQLLQRVFLNGSRQER-----VCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNN 149

  Fly  2625 L-VMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVD----KDLSQPS-- 2682
            . ::::.::.|..:.:||....:|::             :.:||||.||.:|    |.|.:.|  
Human   150 SHILLSALKYPANVAVDPVERFIFWS-------------SEVAGSLYRADLDGVGVKALLETSEK 201

  Fly  2683 --GLAIDYDERRLYWTDAVRE----KIERSDLDGQNRELLVAATIYP-----FAITVFRNYIYWT 2736
              .:::|..::||:|....||    .|...|.||.:    |..:.:|     ||:::|.:.|:::
Human   202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGS----VHISKHPTQHNLFAMSLFGDRIFYS 262

  Fly  2737 DLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGK 2801
            ..:::.::.|.||||.:||.           |.::||      ..|.     |..:..||....|
Human   263 TWKMKTIWIANKHTGKDMVR-----------INLHSS------FVPL-----GELKVVHPLAQPK 305

  Fly  2802 AECKCDDSTKVVNEGRMCAPRNNTCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHS 2866
            ||   ||:.:         |....|:..|     |.|.|.:        ||.:...       |.
Human   306 AE---DDTWE---------PEQKLCKLRK-----GNCSSTV--------CGQDLQS-------HL 338

  Fly  2867 CSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQ-AQVCNGVND 2930
            |                                            .||.|..:.: .:.|..||:
Human   339 C--------------------------------------------MCAEGYALSRDRKYCEDVNE 359

  Fly  2931 CKDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTN 2995
            |                                  .:|                           
Human   360 C----------------------------------AFW--------------------------- 363

  Fly  2996 SFRCPNHRC------IPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYIC 3054
                 ||.|      .|.::||                             ||..|         
Human   364 -----NHGCTLGCKNTPGSYYC-----------------------------TCPVG--------- 385

  Fly  3055 DGDNDCLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTL 3119
                                        |..:                    ||           
Human   386 ----------------------------FVLL--------------------PD----------- 391

  Fly  3120 HNCATQQPCGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIR 3184
                                                    ||.|:                    
Human   392 ----------------------------------------GKRCH-------------------- 396

  Fly  3185 NQSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDEPAHCNVD 3249
                                  :.::||:                                 ||.
Human   397 ----------------------QLVSCPR---------------------------------NVS 406

  Fly  3250 ECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACSQHC-SNTPGGFYC 3313
            ||:        |.||.|..|..|.|.||..|..|||.|:....  ...|.|||.| ..:|..:.|
Human   407 ECS--------HDCVLTSEGPLCFCPEGSVLERDGKTCSGCSS--PDNGGCSQLCVPLSPVSWEC 461

  Fly  3314 KCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQY-NLMHQDLMNVVALDFDIREE 3377
            .|... |:.|.||.:|..... .|:|:|.|...:|:|..||..| .|:.|.:..|.|||.|..|.
Human   462 DCFPG-YDLQLDEKSCAASGP-QPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVEN 524

  Fly  3378 YMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSE 3442
            .:||.....|.|.||....:      :||.:|.......||:|:||:||:.||.||....:..|:
Human   525 KIYFAHTALKWIERANMDGS------QRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSD 583

  Fly  3443 LDGSKRKTL-RSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNA 3506
            |:|.:.|.: :..:..||.|.|||....|::|...:...|....:.|  ..|::..:..:.||:.
Human   584 LNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQG--LGRLVIASSDLIWPSG 646

  Fly  3507 LSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRA 3571
            ::||:.||::||.||....|..|:|:|..|.. |:.:.|.|.||:::|:||:::|||.:.:::|.
Human   647 ITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR-LTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRV 710

  Fly  3572 NKFHGANYTVLRNTTHRPYDLHINHPLRQLPYTNPCGTNNGGCSHLCLIAPPPESTYLNIEGYIE 3636
            ||..|.:...|:.:..:|..|.:.|||.: |..:||...||||.|:|                 :
Human   711 NKRTGKDRVRLQGSMLKPSSLVVVHPLAK-PGADPCLYQNGGCEHIC-----------------K 757

  Fly  3637 EGAPIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCA 3701
            :......|:|...|..|.|.|||:|  ..|..|..|             ||.|.|:      ...
Human   758 KRLGTAWCSCREGFMKASDGKTCLA--LDGHQLLAG-------------GEVDLKN------QVT 801

  Fly  3702 PRHCRAGTFQCKNTNCTPS-----ATICDGVDDCGDRSDEQNCDLPCPLSDFKCKSSGRCILDSW 3761
            |....:.| :....|.|.|     |.|.        .||:.:|   .|:.   |....|||.:. 
Human   802 PLDILSKT-RVSEDNITESQHMLVAEIM--------VSDQDDC---APVG---CSMYARCISEG- 850

  Fly  3762 RCDGDADCK-------DG---SDEDPAVCFKRTCDPKTEFSCKNGRCIPQLWMCDFDNDCGDDSD 3816
               .||.|:       ||   ||.|........|.|      .:.:||               :.
Human   851 ---EDATCQCLKGFAGDGKLCSDIDECEMGVPVCPP------ASSKCI---------------NT 891

  Fly  3817 EPAYMCRQRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKCGNNR 3881
            |..|:||   |:.|:|   |..        :.|...|:|:.......||....|.|..:.|    
Human   892 EGGYVCR---CSEGYQ---GDG--------IHCLDIDECQLGEHSCGENASCTNTEGGYTC---- 938

  Fly  3882 CIPKQWMCDFADDCGDASDENEAVCKGRYRE----CSES-------------EFRCGNGKC-ISS 3928
                                   :|.||..|    |.:|             ..|..:.:| :|.
Human   939 -----------------------MCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSH 980

  Fly  3929 RWQCDHEDDCGDNSDEMHCEG---YQCKNGTFQCASGHCIASYF--RC 3971
            ...|.|:..|      |:.|.   |.|          :|:..|.  ||
Human   981 DGYCLHDGVC------MYIEALDKYAC----------NCVVGYIGERC 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:395011
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1522..1553 CDD:464251
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1729 CDD:459654
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:464251
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:459654
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697 32/144 (22%)
NHL repeat 2593..2622 CDD:271320 5/28 (18%)
NHL repeat 2634..2678 CDD:271320 12/47 (26%)
LY 2671..2713 CDD:214531 16/53 (30%)
LDLa 2867..2901 CDD:238060 1/33 (3%)
LDLa 2906..2941 CDD:238060 7/35 (20%)
LDLa 2950..2983 CDD:238060 1/32 (3%)
LDLa 3034..3066 CDD:197566 3/31 (10%)
LDLa 3080..3115 CDD:197566 3/34 (9%)
LDLa 3128..3159 CDD:238060 0/30 (0%)
LDLa 3170..3204 CDD:238060 0/33 (0%)
LDLa 3210..3242 CDD:197566 2/31 (6%)
FXa_inhibition 3259..3287 CDD:464251 13/27 (48%)
FXa_inhibition 3293..3329 CDD:464251 12/36 (33%)
LY 3362..3394 CDD:214531 13/31 (42%)
LY 3406..3448 CDD:214531 16/41 (39%)
Ldl_recept_b 3468..3511 CDD:459654 8/42 (19%)
LY 3498..3536 CDD:214531 14/37 (38%)
LY 3536..3578 CDD:214531 16/41 (39%)
FXa_inhibition 3607..3659 CDD:464251 13/51 (25%)
LDLa 3663..3696 CDD:238060 7/32 (22%)
LDLa 3705..3739 CDD:238060 8/38 (21%)
LDLa 3743..3775 CDD:197566 11/41 (27%)
LDLa 3784..3817 CDD:197566 4/32 (13%)
LDLa 3827..3861 CDD:197566 7/33 (21%)
LDLa 3871..3901 CDD:197566 2/29 (7%)
LDLa 3913..3947 CDD:238060 9/47 (19%)
LDLa 3952..3986 CDD:238060 5/22 (23%)
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4391 CDD:459654
LY 4374..4417 CDD:214531
NHL repeat 4376..4422 CDD:271320
EGFNP_001954.2 TolB 47..190 CDD:440585 30/163 (18%)
LDL-receptor class B 1 86..127 8/45 (18%)
LDL-receptor class B 2 128..169 6/40 (15%)
LY 152..189 CDD:214531 10/49 (20%)
LDL-receptor class B 3 170..211 12/53 (23%)
LDL-receptor class B 4 212..258 14/49 (29%)
EGF_CA 356..395 CDD:214542 18/241 (7%)
FXa_inhibition 408..436 CDD:464251 14/35 (40%)
FXa_inhibition 439..476 CDD:464251 12/39 (31%)
LDL-receptor class B 5 483..523 16/39 (41%)
LY 505..546 CDD:214531 14/46 (30%)
LDL-receptor class B 6 524..566 14/47 (30%)
LY 547..587 CDD:214531 15/39 (38%)
LDL-receptor class B 7 567..609 15/41 (37%)
LY 590..633 CDD:214531 11/44 (25%)
LDL-receptor class B 8 610..653 9/44 (20%)
LY 635..676 CDD:214531 14/40 (35%)
LDL-receptor class B 9 654..696 16/42 (38%)
LY 677..718 CDD:214531 15/41 (37%)
FXa_inhibition 745..780 CDD:464251 13/51 (25%)
O-glycosylated at one site 801..807 1/5 (20%)
EGF 835..864 CDD:394967 9/38 (24%)
EGF_CA 870..910 CDD:214542 14/74 (19%)
EGF_CA 912..940 CDD:429571 7/54 (13%)
PHA03099 <976..>1014 CDD:165381 13/53 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1108..1131
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1177..1207
Blue background indicates that the domain is not in the aligned region.

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