DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and rme-2

DIOPT Version :10

Sequence 1:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_500815.2 Gene:rme-2 / 177329 WormBaseID:WBGene00004374 Length:925 Species:Caenorhabditis elegans


Alignment Length:983 Identity:261/983 - (26%)
Similarity:381/983 - (38%) Gaps:252/983 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  3858 NSDELPE-NCPKCNPETDFKCGNN--RCIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFR 3919
            |:.:.|. |...|:...:|.|||.  ||||.:|.||...||.:..||:.  |...: .||.|...
 Worm    20 NTAQAPAVNNSTCDQAKEFDCGNGRLRCIPAEWQCDNVADCDNGRDESG--CSYAH-HCSTSFML 81

  Fly  3920 CGNGKCISSRWQCDHEDDCGDNSDEMHCE-----------------------GYQCKNGTFQCAS 3961
            |.||.|:::.::||.||||.|.|||.|||                       |.:|.....:|.|
 Worm    82 CKNGLCVANEFKCDGEDDCRDGSDEQHCEYNILKSRFDGSNPSAPTTFVGHNGPECHPPRLRCRS 146

  Fly  3962 GHCIASYFRCDGDRDCRDMSDEVGC----------------------PPRFPG-GRYCPESRFQC 4003
            |.||.....|||..||....|||.|                      |..|.. ...|......|
 Worm   147 GQCIQPDLVCDGHTDCSGGDDEVNCTRRGHENMQSSTDFHDDVHLVDPTFFANEDNKCRSGYTMC 211

  Fly  4004 NN-NLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCSNERCVARYQICDGVDNCGDGS 4067
            :: ::|:..|.||||..||.|.|||.       ||.|                        ...|
 Worm   212 HSGDVCIPDSFLCDGDLDCDDASDEK-------NCQT------------------------NAPS 245

  Fly  4068 DENNMTLCASKQKPCDLYTQYQCANKH-----CIERSQVCDFSDDCGDASDELGCHHTSSCSEAN 4127
            :|..::..|.....|.....|.|..|.     ||..:..|:...:|     .||...:..|||..
 Worm   246 EEEYLSGQADHMHSCSAAGMYSCGTKGSEIGVCIPMNATCNGIKEC-----PLGDDESKHCSECA 305

  Fly  4128 RGGCQQHCHNLTDGGYICTCYPGYIIAADNKKKCSDVDECLTRQHTCSHQCHNLNGTYSCSCREG 4192
            |..|...|.| |..|..|.|..||.: ||:...|.|.|||.|..|.|.|.|.:..|:::|.|..|
 Worm   306 RKRCDHTCMN-TPHGARCICQEGYKL-ADDGLTCEDEDECATHGHLCQHFCEDRLGSFACKCANG 368

  Fly  4193 FHL-TDGASGVCRAEKEDVI--LLFVN-GQEIR---------GLNWHKSEEFAVIAAEKRIEALD 4244
            :.| |||.|  |:.|.....  .||:: |.|:|         |.|:...::|   |....|.::|
 Worm   369 YELETDGHS--CKYETTTTPEGYLFISLGGEVRQMPLADFTDGSNYSPIQKF---AGHGTIRSID 428

  Fly  4245 YDAQQQIVFW--ADSY-DKTIKRSYMVNAIDGRAKIGFAQDL--NMKGGSKPTAVAVDWLASNLY 4304
            :..:...:|.  :|.: |.|.:.|...|        |..:.|  |:.|.|.   |||||:..|::
 Worm   429 FMHRNNKMFMSISDEHGDPTGELSVSDN--------GLMRVLRENVIGVSN---VAVDWIGGNVF 482

  Fly  4305 WTEMDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTS---IAVNPQLGRIYWSDA-GSAPKIEV 4365
            :|:   ....|...:.:....|.:.|.::. |.|...|   :.|:|..|.|.|.|: ....:|.:
 Worm   483 FTQ---KSPSPSAGISICTMSGMFCRRVIE-GKEQGQSYRGLVVHPMRGLIIWIDSYQKYHRIMM 543

  Fly  4366 SWMDGSKRRPLITEMIRHPAGLTIDYSQDHIIYWVDTKLNAIESMRADGSRRKAIVRGDQLRHPV 4430
            :.||||:.|.|:...:..|:.|.|||.: |.:|:.|.:...||.:..|...|:.:: .:.:.||.
 Worm   544 ANMDGSQVRILLDNKLEVPSALAIDYIR-HDVYFGDVERQLIERVNIDTKERRVVI-SNGVHHPY 606

  Fly  4431 SLDLFESNMFWMTRDTGEL-VRQDKFGRGVQVVLHRYIVNPSGLKVYHDKRYNTSLP-NPCDNST 4493
            .:..|...::|....:..| |::.........|:|.:...|.|:.|.| ..|.|..| |||....
 Worm   607 DMAYFNGFLYWADWGSESLKVQEMTHHHSSPQVIHTFNRYPYGIAVNH-SLYQTGPPSNPCLELE 670

  Fly  4494 CSHLCLLVPGGH-----RCACPDA--------SGPPP------------SHRSTAEV--ICNAAA 4531
            |..||::||...     :|.|||.        |..||            ||..:|.:  .|.|..
 Worm   671 CPWLCVIVPKSDFIMTAKCVCPDGYTHSVTENSCIPPVTIEDEENLEKLSHIGSALMAEYCEAGV 735

  Fly  4532 EHPRPAPRICPCQNGGLCKEDAQGE------LLCECRTQFVGEHCE---TSTMGAFGHGDANVTA 4587
                      .|.|||.|:| .|.|      ::|:|...:.|::||   .....|....|:::..
 Worm   736 ----------ACMNGGACRE-LQNEHGRAHRIVCDCEGPYDGQYCERLNPEKFSAMEEEDSSLWL 789

  Fly  4588 VVVPIMVILLVMMAAAG----AWY-------------------VIRKRPFGKLARMPAMTSSQSV 4629
            :|  :::|.|:::|..|    .|:                   :.||   .:.|..|.:...:.|
 Worm   790 IV--LLLIFLIIVAVVGIIAFLWFSQQEHMKDVISTARVRVDNMARK---AEDAAAPIVEKFRKV 849

  Fly  4630 TFRHGSNVEFNESGFPGASAPGAGDVAPIEGYNLQT--------VNANK-------ARDFANPMY 4679
            |.:..|                   ..|.||....|        .||.|       ...:.||||
 Worm   850 TDKQRS-------------------TPPREGCQTATNVDFVSYETNAEKRIRMDSSPTSYGNPMY 895

  Fly  4680 DAVQSGTT 4687
            |.|...:|
 Worm   896 DEVPESST 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:395011
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1522..1553 CDD:464251
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1729 CDD:459654
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:464251
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:459654
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
FXa_inhibition 3259..3287 CDD:464251
FXa_inhibition 3293..3329 CDD:464251
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
Ldl_recept_b 3468..3511 CDD:459654
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:464251
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566 1/2 (50%)
LDLa 3871..3901 CDD:197566 13/31 (42%)
LDLa 3913..3947 CDD:238060 17/33 (52%)
LDLa 3952..3986 CDD:238060 14/33 (42%)
LDLa 3996..4027 CDD:197566 12/31 (39%)
LDLa 4043..4071 CDD:238060 2/27 (7%)
LDLa 4086..4117 CDD:238060 8/35 (23%)
EGF_CA 4163..4194 CDD:214542 13/30 (43%)
NHL 4276..>4426 CDD:302697 43/155 (28%)
NHL repeat 4291..4336 CDD:271320 10/44 (23%)
Ldl_recept_b 4350..4391 CDD:459654 14/41 (34%)
LY 4374..4417 CDD:214531 13/42 (31%)
NHL repeat 4376..4422 CDD:271320 13/45 (29%)
rme-2NP_500815.2 LDLa 37..69 CDD:238060 15/33 (45%)
LDLa 75..109 CDD:238060 17/33 (52%)
LDLa 137..171 CDD:238060 14/33 (42%)
FXa_inhibition 309..337 CDD:464251 11/29 (38%)
vWFA <337..375 CDD:469594 16/37 (43%)
Ldl_recept_b 527..569 CDD:459654 14/41 (34%)
LY 552..594 CDD:214531 13/42 (31%)
LY 595..634 CDD:214531 6/39 (15%)
Blue background indicates that the domain is not in the aligned region.

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