DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and Lrp8

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_011238756.1 Gene:Lrp8 / 16975 MGIID:1340044 Length:1010 Species:Mus musculus


Alignment Length:827 Identity:292/827 - (35%)
Similarity:412/827 - (49%) Gaps:120/827 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  2867 CSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDC 2931
            |..::|||.|.|||...|:||.:|||.|.|||..|....|.|.:|||.||.|||:.         
Mouse    41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPER--------- 96

  Fly  2932 KDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNS 2996
                                                |.|||:.:|.|.|||....|....||...
Mouse    97 ------------------------------------WKCDGEEECPDGSDESKATCSSEECPAEK 125

  Fly  2997 FRC--PNHRCIPATWYCDGDDDCGDGADEP--PDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGD 3057
            ..|  .:|:|:||:|.|||:.||..||||.  |..|....       |.|.|.:|:..:::||||
Mouse   126 LSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHE-------FQCSNRSCLASVFVCDGD 183

  Fly  3058 NDCLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNC 3122
            :||.|.|||   ..|:|..|... ||.|...     ..|||::|:||...||.|.:||...|  |
Mouse   184 DDCGDGSDE---RGCSDPACPPR-EFRCGGG-----GTCIPERWVCDRQFDCEDRSDEAAEL--C 237

  Fly  3123 --------ATQQPCGED-MFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQ 3178
                    ||...|... .|||.:|.||:.||.||.|.||.|.:||.. |::. ..|...||.|.
Mouse   238 GRAGQGTTATPAACAPTAQFTCRSGECIHLGWRCDGDRDCKDKSDEAD-CSAP-GPCRENEFQCG 300

  Fly  3179 NFKCIRNQSRCDGEDDCGDHSDEVGCAKENITC--PQGQFACTNGQCIDYNLVCNKYPDCADESD 3241
            :..|:....||:.|.||.|.|||.||.:|: ||  |: :|.|.:|:|:|...||:...||.|.||
Mouse   301 DGTCVLAIKRCNQERDCPDGSDEAGCLQES-TCEGPR-RFQCKSGECVDGGKVCDDQRDCRDWSD 363

  Fly  3242 EPAH-C-------------NVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDE 3292
            ||.. |             .::||.. ....|.|.|.|...|:.|.|..|::|| |.|.|.|:||
Mouse   364 EPQKVCVAPSFPGNRRHPRGLNECLH-NNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDE 426

  Fly  3293 CLEQPGACSQHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQY 3357
            | :.|.||||.|.|..|.|.|:| ...||.......||......|.|||||::.||.:.:....|
Mouse   427 C-QDPDACSQICVNYKGYFKCEC-HPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDY 489

  Fly  3358 NLMHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAID 3422
            :.:...|.||||||.::....:|:||::.:.|:.|...:|  .:|.|:..:|....|..||:|:|
Mouse   490 SRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKA--SIPDEQVVLIDEQLHSPEGLAVD 552

  Fly  3423 WVGRKLYWLDRHSKNLDVSELDGSKRKTLRS-GVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGM 3486
            ||.:.:||.|..:|.:.|:..||.:|.||.| .:.:||||.|.|..|::|::.|..||.|.|.|:
Mouse   553 WVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGL 617

  Fly  3487 DGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRH-TVLSGSKVPHVFA 3550
            :|::...::  :|.|.|||.:::|..:.|:||.|:.|..::..|..|.:|. .:.|...:.|.|.
Mouse   618 NGADRQTLV--SDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFG 680

  Fly  3551 LSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQLPYTNPCGTN---NG 3612
            :::|:|.::|:|...:||..||:.:|....:|....:.|:|:.|.|.|:|....:.|..:   ||
Mouse   681 VAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNG 745

  Fly  3613 GCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTC 3659
            ||.:|||.||           .|...:|.:.||||:..:|..|||.|
Mouse   746 GCEYLCLPAP-----------QISSHSPKYTCACPDTMWLGPDMKRC 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 18/33 (55%)
LDLa 2906..2941 CDD:238060 10/34 (29%)
LDLa 2950..2983 CDD:238060 8/32 (25%)
LDLa 3034..3066 CDD:197566 12/31 (39%)
LDLa 3080..3115 CDD:197566 12/34 (35%)
LDLa 3128..3159 CDD:238060 15/31 (48%)
LDLa 3170..3204 CDD:238060 14/33 (42%)
LDLa 3210..3242 CDD:197566 14/33 (42%)
cEGF 3269..3292 CDD:289433 10/22 (45%)
vWFA <3284..3324 CDD:294047 19/39 (49%)
LY 3362..3394 CDD:214531 12/31 (39%)
LY 3406..3448 CDD:214531 15/41 (37%)
LY 3498..3536 CDD:214531 13/37 (35%)
LY 3536..3578 CDD:214531 13/42 (31%)
FXa_inhibition 3607..3659 CDD:291342 20/54 (37%)
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
Lrp8XP_011238756.1 LDLa 41..75 CDD:238060 18/33 (55%)
LDLa 79..111 CDD:197566 17/76 (22%)
LDLa 121..157 CDD:238060 17/35 (49%)
LDLa 200..232 CDD:197566 13/37 (35%)
LDLa 256..286 CDD:238060 16/30 (53%)
LDLa 292..326 CDD:238060 14/33 (42%)
LDLa 330..366 CDD:381805 16/37 (43%)
FXa_inhibition 387..421 CDD:373209 13/35 (37%)
EGF_CA 423..453 CDD:214542 15/31 (48%)
LY 492..527 CDD:214531 12/34 (35%)
LY 537..578 CDD:214531 15/40 (38%)
Ldl_recept_b 599..639 CDD:278487 14/41 (34%)
LY 623..665 CDD:214531 13/43 (30%)
Ldl_recept_b 686..725 CDD:278487 11/38 (29%)
FXa_inhibition 744..781 CDD:373209 19/47 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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