| Sequence 1: | NP_572563.3 | Gene: | mgl / 8674055 | FlyBaseID: | FBgn0261260 | Length: | 4769 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_036011543.1 | Gene: | Lrp1 / 16971 | MGIID: | 96828 | Length: | 4562 | Species: | Mus musculus |
| Alignment Length: | 4497 | Identity: | 1641/4497 - (36%) |
|---|---|---|---|
| Similarity: | 2337/4497 - (51%) | Gaps: | 499/4497 - (11%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 332 CHHAQFRCTNAL-CIPYNFHCDGYHDCADKSDEA-----NCTAIACPDNKHLCPRGGASGTPKCI 390
Fly 391 LKSQLCDGKRDCEDGSDEETNCS--IASCPALSCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDL 453
Fly 454 DECAEWGHCDQLCTNTLGSYTCQCAQGYTLINDSK-CIA---PDANNLQLIFAHDRAIMRMLPHG 514
Fly 515 SE-----PKILANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWAPV 574
Fly 575 ---------------ALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPT 624
Fly 625 AGLMFVADGGQ---VLRAHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLDYIESVDYEG 686
Fly 687 AHRVMVLRGQQVPSPSRLALFENRIYWTDA------TKQGIMSVDKFEGPTSIQVTYKAKDIREP 745
Fly 746 KG--IIAVHALSQPRV-SNPCGNNN----GGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLK 803
Fly 804 LC-KPVSE-FLMYSQQRFIKGKVLEPVIEGF-------SDAIMPV---VSRRARFVGLDFDARDE 856
Fly 857 FIYYSDVLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYI-DSRKGTLNVLSTRNVT 920
Fly 921 H-RRTLLK-NLKRPRAIVVHPNRGFIFFSEWD------RPANITRANTDGSGLLVF-KNVTLGWP 976
Fly 977 NGLSIDFKEDRVYWCDALLDHVQHANLDGTDIKTV-NSRLVRHPFSIVIHNDWMYITDWRLDAII 1040
Fly 1041 RLHK-LTGEQEEMMVREPQTNRLYGVKVYSHEVQRIADTQPCHRNNGGCQKICFAVPIGASNGTD 1104
Fly 1105 GVTTSSPSFGRLQSRCSCPYGERLADDQVSCIPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCD 1169
Fly 1170 GDDDCLDNSDEEQN-CTKPTCGSNEFQCRSGRCIPQNFRCDQENDCGDNSDEQE--CGNVTCGTS 1231
Fly 1232 QFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTC-AYFQFTCPRTGHCIPQSWVCDGDDDCF 1295
Fly 1296 DKQDEKDCP-PI---------------SCLANQFKCADLRQCVEESYKCDGIPDCNDGSDE--VG 1342
Fly 1343 CPSMG---PNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQDCGQIT--CAQNF-FKC-N 1400
Fly 1401 NTNCVFKAYICDGKDDCGDNSDEGAEH----ACVPPPFKCPHGQWQCPGVSERCVNITSV----- 1456
Fly 1457 --CDDTPDCPNGSDEGEGCDLAECEHQAGQCSSFCQKTP-NGALCVCPPGSEIGEDGYTCIDSNE 1518
Fly 1519 CDPPGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLER 1583
Fly 1584 VPIIVENVVATASNMHTGTIFWSDMKLKKISR---LDRG--MEPQEIINTGLDLVEGLAYDWIAQ 1643
Fly 1644 NLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMCIDPSPGARWIFWTDWGEN-PRVERIGMD 1707
Fly 1708 GTMRKTIINT--KIYWPNGLTLDIATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSL 1770
Fly 1771 SLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCA--GSR--C 1831
Fly 1832 QHLCLLSPSAPEGYSCKCRPGFKLLSEGRCIEEENPFLMVVKGTQI--VDLPLNGGDARAGALAP 1894
Fly 1895 ---------VIGIESSTGLDFDRKGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGIVG 1950
Fly 1951 A----PYTIAFDWLGRNL----YIGNRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIAL 2007
Fly 2008 DPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPIVVFQEFAHPESLAVDTEKKMVYYSASNPAVIGV 2072
Fly 2073 MDYNGDDHTLILMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRS 2137
Fly 2138 MMIYKKRALMQH----PCQTNNGGCKHLCIPGPGATRTCACGIGYR-KENEINCVAYKIFAVVSQ 2197
Fly 2198 LDMIRGYSL--SDSSEAMVPISGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQH 2260
Fly 2261 VVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIK 2325
Fly 2326 RLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISY-NG 2389
Fly 2390 ANRKII----RRDLPNPMGIAVYLNDVYWVDRNLM--TVFKASKHSANETATSVRTNL-EKLRDI 2447
Fly 2448 AIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCECATGKLSADERKCEVV 2512
Fly 2513 NEYLVFATRTEIRAVNL-DPHSTEVPFTPL---TNLTNVVGLDFDF-------AHNRMLYTQIRP 2566
Fly 2567 WAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGSE------- 2624
Fly 2625 -LVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDY 2688
Fly 2689 DERRLYWTDAVREKIERSDLDGQNR-ELLVAATIYPFAITVFRNYIYWTDLQLRGVYRAEKHTGA 2752
Fly 2753 NMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDSTKVVNEGR 2817
Fly 2818 MCAPRNNTCEA-SKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIF 2881
Fly 2882 KSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPM 2946
Fly 2947 NTTCPANHLK----------CEKTNICVEPYWLCDGDNDCGDNSDE-DPLHCGQRTCPTNSFRCP 3000
Fly 3001 NHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSD 3065
Fly 3066 EDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQPCGE 3130
Fly 3131 DMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRN-QSRCDGEDD 3194
Fly 3195 CGDHSDEVGCAKENITC--PQ------GQFACTNGQCIDYNLVCNKYPDCADESDEPAHCNVDEC 3251
Fly 3252 AKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCD 3316
Fly 3317 ETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYF 3381
Fly 3382 CDVTAK-TIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDG 3445
Fly 3446 SKRKTL-RSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSI 3509
Fly 3510 DYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKF 3574
Fly 3575 HGANYTVLRNTTHRPYDLHINHPLRQLPYTN-PCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEG 3638
Fly 3639 APIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPR 3703
Fly 3704 HCRAGTFQCKNTNCTPSATICDGVDDCGDRSDEQNCDL-PCPLSDFKCKSSGRCILDSWRCDGDA 3767
Fly 3768 DCKDGSDEDPAVCFKRTCDPKTEFSCK-NGRCIPQLWMCDFDNDCGDDSDEPAYMCRQRNCTTGW 3831
Fly 3832 QRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPK--CNPETDFKCGNNRCIPKQWMCDFADD 3894
Fly 3895 CGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGTFQC 3959
Fly 3960 ASGHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCPESRFQCNNNLCVSLSDLCDGTDDCGDG 4024
Fly 4025 SDEDPSVCSDFNCDTLRRFQCSNER-CVARYQICDGVDNCGDGSDENNMTLCASKQKPCDLYTQY 4088
Fly 4089 QCANKHCIERSQVCDFSDDCGDASDELGC----HHTSSCSEANRGGCQQHCHNLTDGGYICTCYP 4149
Fly 4150 GYIIAADNKKKCSDVDECLTRQHTCSHQCHNLNGTYSCSCREGFHLTDGASGVCRAEKEDVILLF 4214
Fly 4215 V-NGQEIRGL---NWHKSEEFAVIAAEK-RIEALDYDAQQQIVFWADSYDKTIKRSYMVNAID-- 4272
Fly 4273 ----GRAKI--GFAQDLNMKGGSKPTAVAVDWLASNLYWTEMDRTGSKPRGRVMVAKTDGRYRRS 4331
Fly 4332 IVNAGLEVPTSIAVNPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEMIRHPAGLTIDYSQDHI 4396
Fly 4397 IYWVDTKLNAIESMRADGSRRKAIVRGDQ---LRHPVSLDLFESNMFWMTRDTGELVRQDKFGRG 4458
Fly 4459 VQVVLHRYIVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLLVPGGHRCACPD------------ 4511
Fly 4512 -ASGPPPSHRSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELLCECRTQFVGEHCETSTM 4575
Fly 4576 GAFGHGDANVTA 4587 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| mgl | NP_572563.3 | LDLa | 157..189 | CDD:238060 | |
| LDLa | 204..236 | CDD:238060 | |||
| LDLa | 292..327 | CDD:238060 | |||
| LDLa | 332..366 | CDD:238060 | 16/39 (41%) | ||
| LDLa | 371..412 | CDD:238060 | 19/40 (48%) | ||
| vWFA | <447..488 | CDD:469594 | 23/40 (58%) | ||
| YncE | <492..634 | CDD:442618 | 37/161 (23%) | ||
| NHL | 573..>716 | CDD:302697 | 52/160 (33%) | ||
| NHL repeat | 573..610 | CDD:271320 | 9/51 (18%) | ||
| NHL repeat | 616..654 | CDD:271320 | 16/40 (40%) | ||
| NHL repeat | 657..693 | CDD:271320 | 18/35 (51%) | ||
| FXa_inhibition | 763..805 | CDD:464251 | 14/45 (31%) | ||
| YvrE | 854..>992 | CDD:442613 | 55/147 (37%) | ||
| LY | 922..964 | CDD:214531 | 17/48 (35%) | ||
| LY | 973..1007 | CDD:214531 | 15/33 (45%) | ||
| Ldl_recept_a | 1188..1223 | CDD:395011 | 17/36 (47%) | ||
| LDLa | 1227..1259 | CDD:197566 | 19/31 (61%) | ||
| LDLa | 1268..1303 | CDD:238060 | 17/35 (49%) | ||
| LDLa | 1308..1343 | CDD:238060 | 17/36 (47%) | ||
| LDLa | 1356..1387 | CDD:238060 | 16/30 (53%) | ||
| LDLa | 1391..1423 | CDD:197566 | 16/35 (46%) | ||
| LDLa | 1435..1469 | CDD:197566 | 12/40 (30%) | ||
| FXa_inhibition | 1522..1553 | CDD:464251 | 14/30 (47%) | ||
| LY | 1625..1665 | CDD:214531 | 20/39 (51%) | ||
| LY | 1667..1711 | CDD:214531 | 17/44 (39%) | ||
| Ldl_recept_b | 1690..1729 | CDD:459654 | 19/41 (46%) | ||
| LY | 1712..1754 | CDD:214531 | 16/43 (37%) | ||
| LY | 1986..2037 | CDD:214531 | 10/50 (20%) | ||
| FXa_inhibition | 2151..>2179 | CDD:464251 | 13/27 (48%) | ||
| LY | 2259..2305 | CDD:214531 | 18/45 (40%) | ||
| Ldl_recept_b | 2326..2366 | CDD:459654 | 14/39 (36%) | ||
| LY | 2352..2392 | CDD:214531 | 14/40 (35%) | ||
| NHL | 2579..>2711 | CDD:302697 | 45/139 (32%) | ||
| NHL repeat | 2593..2622 | CDD:271320 | 8/28 (29%) | ||
| NHL repeat | 2634..2678 | CDD:271320 | 15/43 (35%) | ||
| LY | 2671..2713 | CDD:214531 | 18/41 (44%) | ||
| LDLa | 2867..2901 | CDD:238060 | 15/33 (45%) | ||
| LDLa | 2906..2941 | CDD:238060 | 16/34 (47%) | ||
| LDLa | 2950..2983 | CDD:238060 | 17/43 (40%) | ||
| LDLa | 3034..3066 | CDD:197566 | 13/31 (42%) | ||
| LDLa | 3080..3115 | CDD:197566 | 14/34 (41%) | ||
| LDLa | 3128..3159 | CDD:238060 | 15/30 (50%) | ||
| LDLa | 3170..3204 | CDD:238060 | 18/34 (53%) | ||
| LDLa | 3210..3242 | CDD:197566 | 14/39 (36%) | ||
| FXa_inhibition | 3259..3287 | CDD:464251 | 10/27 (37%) | ||
| FXa_inhibition | 3293..3329 | CDD:464251 | 15/35 (43%) | ||
| LY | 3362..3394 | CDD:214531 | 16/32 (50%) | ||
| LY | 3406..3448 | CDD:214531 | 15/41 (37%) | ||
| Ldl_recept_b | 3468..3511 | CDD:459654 | 19/42 (45%) | ||
| LY | 3498..3536 | CDD:214531 | 21/37 (57%) | ||
| LY | 3536..3578 | CDD:214531 | 24/41 (59%) | ||
| FXa_inhibition | 3607..3659 | CDD:464251 | 21/51 (41%) | ||
| LDLa | 3663..3696 | CDD:238060 | 18/32 (56%) | ||
| LDLa | 3705..3739 | CDD:238060 | 19/33 (58%) | ||
| LDLa | 3743..3775 | CDD:197566 | 14/31 (45%) | ||
| LDLa | 3784..3817 | CDD:197566 | 18/33 (55%) | ||
| LDLa | 3827..3861 | CDD:197566 | 15/33 (45%) | ||
| LDLa | 3871..3901 | CDD:197566 | 16/29 (55%) | ||
| LDLa | 3913..3947 | CDD:238060 | 21/33 (64%) | ||
| LDLa | 3952..3986 | CDD:238060 | 19/33 (58%) | ||
| LDLa | 3996..4027 | CDD:197566 | 19/30 (63%) | ||
| LDLa | 4043..4071 | CDD:238060 | 17/28 (61%) | ||
| LDLa | 4086..4117 | CDD:238060 | 13/30 (43%) | ||
| EGF_CA | 4163..4194 | CDD:214542 | 14/30 (47%) | ||
| NHL | 4276..>4426 | CDD:302697 | 56/154 (36%) | ||
| NHL repeat | 4291..4336 | CDD:271320 | 14/44 (32%) | ||
| Ldl_recept_b | 4350..4391 | CDD:459654 | 19/40 (48%) | ||
| LY | 4374..4417 | CDD:214531 | 16/42 (38%) | ||
| NHL repeat | 4376..4422 | CDD:271320 | 17/45 (38%) | ||
| Lrp1 | XP_036011543.1 | LDLa | 27..60 | CDD:197566 | 13/31 (42%) |
| LDLa | 72..105 | CDD:197566 | 17/37 (46%) | ||
| FXa_inhibition | 120..149 | CDD:464251 | 9/28 (32%) | ||
| FXa_inhibition | 159..189 | CDD:464251 | 17/29 (59%) | ||
| LY | 276..315 | CDD:214531 | 8/38 (21%) | ||
| LY | 317..359 | CDD:214531 | 17/41 (41%) | ||
| LY | 362..402 | CDD:214531 | 18/39 (46%) | ||
| FXa_inhibition | 487..520 | CDD:464251 | 12/37 (32%) | ||
| LY | 552..594 | CDD:214531 | 15/45 (33%) | ||
| LY | 595..634 | CDD:214531 | 16/38 (42%) | ||
| LY | 641..690 | CDD:214531 | 17/48 (35%) | ||
| LY | <701..734 | CDD:214531 | 16/32 (50%) | ||
| FXa_inhibition | 808..843 | CDD:464251 | 16/53 (30%) | ||
| LDLa | 854..886 | CDD:197566 | 19/33 (58%) | ||
| LDLa | 896..929 | CDD:238060 | 16/32 (50%) | ||
| LDLa | 936..968 | CDD:197566 | 19/31 (61%) | ||
| LDLa | 979..1012 | CDD:238060 | 16/33 (48%) | ||
| LDLa | 1033..1066 | CDD:238060 | 17/33 (52%) | ||
| LDLa | 1080..1115 | CDD:238060 | 17/35 (49%) | ||
| LDLa | 1122..1158 | CDD:238060 | 18/37 (49%) | ||
| LDLa | 1163..1196 | CDD:238060 | 15/46 (33%) | ||
| FXa_inhibition | 1203..1239 | CDD:464251 | 14/35 (40%) | ||
| Vgb | 1328..>1521 | CDD:443399 | 75/194 (39%) | ||
| LY | 1354..1394 | CDD:214531 | 19/39 (49%) | ||
| LY | 1398..1441 | CDD:214531 | 17/44 (39%) | ||
| LY | 1631..1667 | CDD:214531 | 10/46 (22%) | ||
| LY | 1668..1711 | CDD:214531 | 15/45 (33%) | ||
| LY | 1715..1752 | CDD:214531 | 10/50 (20%) | ||
| LY | 1752..1793 | CDD:214531 | 9/40 (23%) | ||
| FXa_inhibition | 1868..1904 | CDD:464251 | 14/35 (40%) | ||
| LY | 1934..1974 | CDD:214531 | 11/43 (26%) | ||
| LY | 1977..2017 | CDD:214531 | 18/43 (42%) | ||
| LY | 2018..2061 | CDD:214531 | 16/42 (38%) | ||
| LY | 2063..2105 | CDD:214531 | 14/41 (34%) | ||
| FXa_inhibition | 2177..2212 | CDD:464251 | 17/45 (38%) | ||
| LY | 2293..2333 | CDD:214531 | 13/40 (33%) | ||
| Ldl_recept_b | 2362..2404 | CDD:459654 | 14/43 (33%) | ||
| LY | 2388..2429 | CDD:214531 | 18/40 (45%) | ||
| FXa_inhibition | 2500..2532 | CDD:464251 | 12/32 (38%) | ||
| LDLa | 2545..2575 | CDD:238060 | 14/29 (48%) | ||
| LDLa | 2584..2618 | CDD:238060 | 15/33 (45%) | ||
| LDLa | 2623..2657 | CDD:238060 | 16/37 (43%) | ||
| LDLa | <2684..2706 | CDD:238060 | 14/21 (67%) | ||
| LDLa | 2714..2748 | CDD:238060 | 19/35 (54%) | ||
| LDLa | 2752..2783 | CDD:197566 | 13/30 (43%) | ||
| LDLa | 2791..2824 | CDD:197566 | 15/38 (39%) | ||
| LDLa | 2835..2867 | CDD:197566 | 15/31 (48%) | ||
| LDLa | 2875..2908 | CDD:197566 | 17/32 (53%) | ||
| LDLa | 2925..2957 | CDD:238060 | 14/32 (44%) | ||
| FXa_inhibition | 2969..2998 | CDD:464251 | 10/28 (36%) | ||
| EGF_CA | 3000..>3029 | CDD:214542 | 14/29 (48%) | ||
| LY | 3067..3111 | CDD:214531 | 18/43 (42%) | ||
| LY | 3112..3154 | CDD:214531 | 16/46 (35%) | ||
| LY | 3156..3198 | CDD:214531 | 20/41 (49%) | ||
| LY | 3200..3241 | CDD:214531 | 22/42 (52%) | ||
| LY | 3242..3282 | CDD:214531 | 23/40 (58%) | ||
| FXa_inhibition | 3312..3348 | CDD:464251 | 21/51 (41%) | ||
| LDLa | 3352..3383 | CDD:238060 | 18/32 (56%) | ||
| LDLa | 3392..3426 | CDD:238060 | 19/33 (58%) | ||
| LDLa | 3431..3466 | CDD:238060 | 16/36 (44%) | ||
| LDLa | 3470..3503 | CDD:197566 | 18/33 (55%) | ||
| LDLa | 3511..3544 | CDD:197566 | 15/34 (44%) | ||
| LDLa | 3554..3588 | CDD:238060 | 19/34 (56%) | ||
| LDLa | 3593..3627 | CDD:238060 | 21/33 (64%) | ||
| LDLa | 3631..3665 | CDD:238060 | 19/33 (58%) | ||
| LDLa | 3671..3703 | CDD:197566 | 19/31 (61%) | ||
| LDLa | 3713..3749 | CDD:238060 | 19/35 (54%) | ||
| LDLa | 3764..3794 | CDD:238060 | 13/29 (45%) | ||
| YncE | 3880..4082 | CDD:442618 | 66/209 (32%) | ||
| LY | 3973..4010 | CDD:214531 | 14/42 (33%) | ||
| Ldl_recept_b | 4031..4072 | CDD:459654 | 19/40 (48%) | ||
| LY | 4055..4096 | CDD:214531 | 16/43 (37%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||