DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and Ldlr

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_034830.2 Gene:Ldlr / 16835 MGIID:96765 Length:862 Species:Mus musculus


Alignment Length:851 Identity:276/851 - (32%)
Similarity:404/851 - (47%) Gaps:176/851 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  2824 NTCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNN--GRCIFKSWKC 2886
            ::|..::|.|::|:||:..|.|||..:|.|.|||.|..|...:|..|:|.|..  .|||..||:|
Mouse    25 DSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRC 89

  Fly  2887 DHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCP 2951
            |.:.||::.|||.||....|...:|.|.:|:||                                
Mouse    90 DGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCI-------------------------------- 122

  Fly  2952 ANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDD 3016
                         .|.::||||.||.|.|||  .||...||....|||.:..|||:.|.||||.|
Mouse   123 -------------SPQFVCDGDRDCLDGSDE--AHCQATTCGPAHFRCNSSICIPSLWACDGDVD 172

  Fly  3017 CGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEET 3081
            |.||:||.|..|  :||.      |...|                                    
Mouse   173 CVDGSDEWPQNC--QGRD------TASKG------------------------------------ 193

  Fly  3082 EFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQPCGEDMFTCGNGRCINKGWI 3146
                                                      ...||....|.||:..||::.|:
Mouse   194 ------------------------------------------VSSPCSSLEFHCGSSECIHRSWV 216

  Fly  3147 CDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRNQSRCDGEDDCGDHSDEVGCAKENITC 3211
            ||.:.||.|.:|| :.|  ...||...||.|.:..||....:||.|.||.|.|||:||.  |:|.
Mouse   217 CDGEADCKDKSDE-EHC--AVATCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCV--NVTQ 276

  Fly  3212 PQG--QFACTNGQCIDYNLVCNKYPDCADESDEP-AHCNVDECAKVEIN-QCGHKCVDTLTGYYC 3272
            ..|  :|.|.:|:||..:.||:...||.|.|||| ..|..:||  ::.| .|.|.|.|...|..|
Mouse   277 CDGPNKFKCHSGECISLDKVCDSARDCQDWSDEPIKECKTNEC--LDNNGGCSHICKDLKIGSEC 339

  Fly  3273 DCNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCDETYYERQNDEHT--CKRKDKI 3335
            .|..|::|: |...|.|:||| ::|..|||.|.|..|.:.|:|...::   .|.||  ||....|
Mouse   340 LCPSGFRLV-DLHRCEDIDEC-QEPDTCSQLCVNLEGSYKCECQAGFH---MDPHTRVCKAVGSI 399

  Fly  3336 PPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDE 3400
             .:|:|||::.||.|::|..:|..:..:|.||||||.::....:|:.|::.|.|:.|...:|.: 
Mouse   400 -GYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPN- 462

  Fly  3401 MPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVDPRAIVVH 3464
              ...:.:|..|.|..:|:|:||:.|.:||.|....::.|::..|.||:|| :.....||||||.
Mouse   463 --LSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVD 525

  Fly  3465 PGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYA 3529
            |..|::|:|.|...|.|.|.|::|.:...::..|  |.|||.:::|..:.|:||.|:.|..|:..
Mouse   526 PVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTEN--IQWPNGITLDLSSGRLYWVDSKLHSISSI 588

  Fly  3530 DLEGRHRHTVLSG-SKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLH 3593
            |:.|.:|.|:|.. :::.|.|:|::::|.:||:|...:||..||:..|::..::......|.|:.
Mouse   589 DVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVNLVAENLLSPEDIV 653

  Fly  3594 INHPLRQLPYTNPCGTN----NGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLAR 3654
            :.|.:.|....|.|.|.    ||||.:|||.||           .|...:|.|.||||:...||:
Mouse   654 LFHKVTQPRGVNWCETTALLPNGGCQYLCLPAP-----------QIGPHSPKFTCACPDGMLLAK 707

  Fly  3655 DMKTCV 3660
            ||::|:
Mouse   708 DMRSCL 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 16/35 (46%)
LDLa 2906..2941 CDD:238060 6/34 (18%)
LDLa 2950..2983 CDD:238060 10/32 (31%)
LDLa 3034..3066 CDD:197566 2/31 (6%)
LDLa 3080..3115 CDD:197566 0/34 (0%)
LDLa 3128..3159 CDD:238060 12/30 (40%)
LDLa 3170..3204 CDD:238060 15/33 (45%)
LDLa 3210..3242 CDD:197566 13/33 (39%)
cEGF 3269..3292 CDD:289433 8/22 (36%)
vWFA <3284..3324 CDD:294047 14/39 (36%)
LY 3362..3394 CDD:214531 12/31 (39%)
LY 3406..3448 CDD:214531 13/41 (32%)
LY 3498..3536 CDD:214531 14/37 (38%)
LY 3536..3578 CDD:214531 15/42 (36%)
FXa_inhibition 3607..3659 CDD:291342 22/55 (40%)
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
LdlrNP_034830.2 Ldl_recept_a 25..58 CDD:278486 13/32 (41%)
Ldl_recept_a 66..104 CDD:278486 16/37 (43%)
Ldl_recept_a 107..143 CDD:278486 17/82 (21%)
Ldl_recept_a 146..184 CDD:278486 20/37 (54%)
Ldl_recept_a 196..232 CDD:278486 15/36 (42%)
Ldl_recept_a 236..271 CDD:278486 16/34 (47%)
Ldl_recept_a 279..309 CDD:278486 12/29 (41%)
FXa_inhibition 319..>347 CDD:291342 10/29 (34%)
EGF_CA 355..389 CDD:214542 14/37 (38%)
LDL-receptor class B 1 398..439 17/41 (41%)
LY 420..458 CDD:214531 13/37 (35%)
LDL-receptor class B 2 440..485 13/47 (28%)
Ldl_recept_b 440..482 CDD:278487 11/44 (25%)
LDL-receptor class B 3 486..528 17/41 (41%)
Ldl_recept_b 486..525 CDD:278487 15/38 (39%)
LDL-receptor class B 4 529..572 15/44 (34%)
Ldl_recept_b 529..569 CDD:278487 14/41 (34%)
LY 553..595 CDD:214531 14/43 (33%)
LDL-receptor class B 5 573..615 14/41 (34%)
LDL-receptor class B 6 616..658 12/41 (29%)
Ldl_recept_b 616..655 CDD:278487 11/38 (29%)
FXa_inhibition 675..712 CDD:291342 20/47 (43%)
Clustered O-linked oligosaccharides 722..770
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..761
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 813..862
NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 825..830
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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