DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and Egf

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_011238312.1 Gene:Egf / 13645 MGIID:95290 Length:1221 Species:Mus musculus


Alignment Length:1411 Identity:291/1411 - (20%)
Similarity:492/1411 - (34%) Gaps:508/1411 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   499 LIFAHDRAIMRMLPHG-SEPKILANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQN-KAVS 561
            |:|:..::|.|:.|.| :..:::.:|..:|.:..||.:..|||.|::.:.:..:.|:... :.|.
Mouse    55 LVFSQGKSISRIDPDGTNHQQLVVDAGISADMDIHYKKERLYWVDVERQVLLRVFLNGTGLEKVC 119

  Fly   562 PFDQTLPGTWAPVALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAG 626
            ..::.:.|      ||:||:.|::...|.....|.|.:::|: ::.||.|:|..|:::|:||...
Mouse   120 NVERKVSG------LAIDWIDDEVLWVDQQNGVITVTDMTGK-NSRVLLSSLKHPSNIAVDPIER 177

  Fly   627 LMFVAD--GGQVLRAHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLD----YIESVDYE 685
            |||.:.  .|.:.|||:.|...::::....  .|.:|:|::.||:||.....:    ||.|.|||
Mouse   178 LMFWSSEVTGSLHRAHLKGVDVKTLLETGG--ISVLTLDVLDKRLFWVQDSGEGSHAYIHSCDYE 240

  Fly   686 GAHRVMVLRGQQVPSPSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTYKAKDIREPKGIIA 750
            |. .|.::|.|...|.|.:|.|.:||:::....:.|...:|..|..::::......: .|..::.
Mouse   241 GG-SVRLIRHQARHSLSSMAFFGDRIFYSVLKSKAIWIANKHTGKDTVRINLHPSFV-TPGKLMV 303

  Fly   751 VHALSQPRVS------------------------------------------------------N 761
            ||..:|||..                                                      |
Mouse   304 VHPRAQPRTEDAAKDPGESLDPELLKQRGRPCRFGLCERDPKSHSSACAEGYTLSRDRKYCEDVN 368

  Fly   762 PCGNNNGG-----------------------------------------CNHMCIVTA-----VK 780
            .|...|.|                                         |:|.|::|:     :.
Mouse   369 ECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQCHELVSCPGNVSKCSHGCVLTSDGPRCIC 433

  Fly   781 GAPTGLG----------------------------FRCACSTGYQLETDLKLC-----KPVSEFL 812
            .|.:.||                            :.|.|..||.|::|.|.|     :|:   |
Mouse   434 PAGSVLGRDGKTCTGCSSPDNGGCSQICLPLRPGSWECDCFPGYDLQSDRKSCAASGPQPL---L 495

  Fly   813 MYSQQRFIKG--------KVLEPVIEGFSDAIMPVVSRRARFV-GLDFDARDEFIYYSDVLQDVI 868
            :::..:.|:.        |||              :||:...| .||:|..:..||::......|
Mouse   496 LFANSQDIRHMHFDGTDYKVL--------------LSRQMGMVFALDYDPVESKIYFAQTALKWI 546

  Fly   869 YRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVTHRRTLLKNLKRPR 933
            .|.:.:|:.||.::....:.:||||:||..:.:|:.||.|..:.........||..:.:.:.|||
Mouse   547 ERANMDGSQRERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHHRIIIQERISRPR 611

  Fly   934 AIVVHPNRGFIFFSEWDRPANITRANTDGSGLLVFKNVTLGWPNGLSIDFKEDRVYWCDALLDHV 998
            .|.|||....:|:::......|..|:..||..::..:..|..|:|::||:..|.:||||.....:
Mouse   612 GIAVHPRARRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDYLTDTLYWCDTKRSVI 676

  Fly   999 QHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRLDAIIRLHKLTGEQEEMMVREPQTNRLY 1063
            :.|||||:..:.:....|.||||:.:..|.::::||.:.::||::|.||:...         ||.
Mouse   677 EMANLDGSKRRRLIQNDVGHPFSLAVFEDHLWVSDWAIPSVIRVNKRTGQNRV---------RLQ 732

  Fly  1064 GVK------VYSHEVQRIADTQPCHRNNGGCQKICFAVPIGASNGTDGVTTSSPSFGRLQSRCSC 1122
            |..      |..|.:.: ....||...||||:.||     ..|.||              :||.|
Mouse   733 GSMLKPSSLVVVHPLAK-PGADPCLYRNGGCEHIC-----QESLGT--------------ARCLC 777

  Fly  1123 PYGERLADDQVSCIPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCDGDDDCLDNSDEEQNCTKP 1187
            ..|                                    ..|:|  ||.                
Mouse   778 REG------------------------------------FVKAW--DGK---------------- 788

  Fly  1188 TCGSNEFQCRSGRCIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSEND 1252
                        .|:||::....    |:|:|..:  .||            .:.|..:.:..:|
Mouse   789 ------------MCLPQDYPILS----GENADLSK--EVT------------SLSNSTQAEVPDD 823

  Fly  1253 CGDSSDEGDFCAEKTCAYFQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCAD 1317
              |.::.....||...:...:                 :|||                       
Mouse   824 --DGTESSTLVAEIMVSGMNY-----------------EDDC----------------------- 846

  Fly  1318 LRQCVEESYKCDGIPDCNDGSDEVGCPSMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHS 1382
                                         ||..|.  .|.||.|.|                   
Mouse   847 -----------------------------GPGGCG--SHARCVSDG------------------- 861

  Fly  1383 DEQDCGQITCAQNFFKCNNTNCVFKAYICDGKDDCG-DNSDEGAEHACVPPPFKCPHGQWQCPGV 1446
               :..:..|.:.|.:..|        :|...|:|. ..||                    ||..
Mouse   862 ---ETAECQCLKGFARDGN--------LCSDIDECVLARSD--------------------CPST 895

  Fly  1447 SERCVNITS--VCDDTPDCPNGSDEGEG--C-DLAECEHQAGQC--SSFCQKTPNGALCVC---- 1500
            |.||:|...  ||    .|..|. ||:|  | |:.||:..|..|  ::.|..|..|..|.|    
Mouse   896 SSRCINTEGGYVC----RCSEGY-EGDGISCFDIDECQRGAHNCGENAACTNTEGGYNCTCAGRP 955

  Fly  1501 -PPG---------SEIGEDGYTCIDSNE-----------CDPPGLCSQQCTNTKGSYFCSCTDGY 1544
             .||         |.:||||:. :|.|.           |...|:|..  ..:..||.|:|..||
Mouse   956 SSPGLSCPDSTAPSLLGEDGHH-LDRNSYPGCPSSYDGYCLNGGVCMH--IESLDSYTCNCVIGY 1017

  Fly  1545 VLEPNKHTCKA-------VNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGT 1602
                :...|:.       :.|..    ...:|.|:|..:         .:|..|:.....| .||
Mouse  1018 ----SGDRCQTRDLRWWELRHAG----YGQKHDIMVVAV---------CMVALVLLLVLGM-WGT 1064

  Fly  1603 IFWSDMKLKKISRLDRGM--EPQ-EIINTGLDLVEGLA-----YDWIAQNLYWLDSKLNTIEVSA 1659
            .::...  |::|...:..  ||. .:.::|.:...|.|     ..|........|.|..::....
Mouse  1065 YYYRTR--KQLSNPPKNPCDEPSGSVSSSGPNSSSGAAVASCPQPWFVVLEKHQDPKNGSLPADG 1127

  Fly  1660 ENGSNRLVLVRENITQPRGMCIDPSPGARWIFWTDWGENPRVERIG 1705
            .||:    :|...::        ||.....:..|.|.:.|.::.:|
Mouse  1128 TNGA----VVDAGLS--------PSLQLGSVHLTSWRQKPHIDGMG 1161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697 48/148 (32%)
NHL repeat 573..610 CDD:271320 10/36 (28%)
NHL repeat 616..654 CDD:271320 12/39 (31%)
NHL repeat 657..693 CDD:271320 15/39 (38%)
FXa_inhibition 763..805 CDD:291342 17/115 (15%)
LY 922..964 CDD:214531 12/41 (29%)
LY 973..1007 CDD:214531 15/33 (45%)
Ldl_recept_a 1188..1223 CDD:278486 6/34 (18%)
LDLa 1227..1259 CDD:197566 4/31 (13%)
LDLa 1268..1303 CDD:238060 3/34 (9%)
LDLa 1308..1343 CDD:238060 0/34 (0%)
LDLa 1356..1387 CDD:238060 5/30 (17%)
LDLa 1391..1423 CDD:197566 7/32 (22%)
LDLa 1435..1469 CDD:197566 10/35 (29%)
FXa_inhibition 1478..1513 CDD:291342 15/50 (30%)
FXa_inhibition 1522..1553 CDD:291342 8/30 (27%)
LY 1625..1665 CDD:214531 8/44 (18%)
LY 1667..1711 CDD:214531 7/39 (18%)
Ldl_recept_b 1690..1728 CDD:278487 4/16 (25%)
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
EgfXP_011238312.1 LY <86..114 CDD:214531 7/27 (26%)
LY <125..156 CDD:214531 10/37 (27%)
LY 158..199 CDD:214531 16/40 (40%)
FXa_inhibition 370..405 CDD:373209 3/34 (9%)
FXa_inhibition 418..446 CDD:373209 7/27 (26%)
FXa_inhibition 453..486 CDD:373209 7/32 (22%)
LY 514..556 CDD:214531 14/55 (25%)
LY 557..599 CDD:214531 11/41 (27%)
LY 600..643 CDD:214531 13/42 (31%)
LY 643..686 CDD:214531 15/42 (36%)
LY 687..728 CDD:214531 13/40 (33%)
FXa_inhibition 755..790 CDD:373209 18/119 (15%)
EGF_CA 881..921 CDD:311536 17/64 (27%)
EGF_CA 923..>951 CDD:311536 9/27 (33%)
PHA02887 <986..1023 CDD:165214 9/42 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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