DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and SORCS1

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_001374485.1 Gene:SORCS1 / 114815 HGNCID:16697 Length:1203 Species:Homo sapiens


Alignment Length:1085 Identity:199/1085 - (18%)
Similarity:332/1085 - (30%) Gaps:387/1085 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1639 DWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMCIDPSPGARWIFWTDWGENPRVER 1703
            |||.  .|..|.||.:   |||.| .|..|::|.:...|            .:|:..|.|...:.
Human   285 DWIL--AYSQDQKLYS---SAEFG-RRWQLIQEGVVPNR------------FYWSVMGSNKEPDL 331

  Fly  1704 IGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPH 1768
            :.::..                |:|                              ..||||    
Human   332 VHLEAR----------------TVD------------------------------GHSHYL---- 346

  Fly  1769 SLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCAGSRCQH 1833
                       |.|..| ...||    :||....::....|.:..|:..:|              
Human   347 -----------TCRMQN-CTEAN----RNQPFPGYIDPDSLIVQDHYVFVQ-------------- 381

  Fly  1834 LCLLSPSAPEGYSCKCR--------PGFKLLSEGRCI--EEENPFLMVVKGTQIVDLPLNGGDAR 1888
              |.|...|..|....|        |.:.|..:...|  :|...|..|.:..|.....|...|.|
Human   382 --LTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTR 444

  Fly  1889 AGALAPVI-GIESSTG------LDFDRKGETLYWVQG-------REDDDENCTIYTTPYGGGNKT 1939
            .......: .::||.|      :|       ||.|.|       .:..|.....:.|...|.:..
Human   445 GVYFTLALENVQSSRGPEGNIMID-------LYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWR 502

  Fly  1940 LFLGIENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAVRVDGKQKYRT-IILANDGYPNSVSRPK 2003
            |....:..:.|.|......:...:|::  :|:.|          .|.: ||.:.|..|:.:....
Human   503 LLQAPDTDLRGDPVHCLLPYCSLHLHL--KVSEN----------PYTSGIIASKDTAPSIIVASG 555

  Fly  2004 QIA--LDPTEGKLF--------WIDEGVLEVPIKIGRVDMNGQNPIVVFQEFAHPES---LAVDT 2055
            .|.  |..|:..:|        |  ..:.|....:..:|..|  .:|..:..:.|..   |:.|.
Human   556 NIGSELSDTDISMFVSSDAGNTW--RQIFEEEHSVLYLDQGG--VLVAMKHTSLPIRHLWLSFDE 616

  Fly  2056 EKKMVYYS-ASNPAVI-GVMDYNGDDHTLILMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRID 2118
            .:....|| .|.|..: ||:...|:: |||:....|          ..||..:      ::|::|
Human   617 GRSWSKYSFTSIPLFVDGVLGEPGEE-TLIMTVFGH----------FSHRSEW------QLVKVD 664

  Fly  2119 LPHGDNPKTIVDN---ESDLR--------------SMMIYKKR-------------ALMQHPC-- 2151
            .      |:|.|.   |.|.|              :..|||||             |:...||  
Human   665 Y------KSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVC 723

  Fly  2152 ------------QTNNGGCKHLCIPGPGA-TRTCACG------IGYRKENEINCV---------- 2187
                        :.:||.|.......|.: ::.|:.|      .||||....||.          
Human   724 TEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAK 788

  Fly  2188 ----------AYKIFAVVSQLDMIRGYSLS--------DSSEAMVPIS-GPGHHILHVDVMYREQ 2233
                      ..:|.....:|...:|::::        |....::.:. |.|..:.:|::...|.
Human   789 PQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMED 853

  Fly  2234 WIYWAEYNRGYWN-GIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHEN-YVE 2296
            .|     ...|.| ||||     ..:|  |.:.:||:          :..:|.....|.|: ::.
Human   854 GI-----KHVYQNVGIFR-----VTVQ--VDNSLGSD----------SAVLYLHVTCPLEHVHLS 896

  Fly  2297 VCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLY--WIDYGQHPRIGKALLDGSKWTPLVTSGISL 2359
            :.::...|::|      :|...|..:.:..|.|  |......|.|   .|:||......:.|:: 
Human   897 LPFVTTKNKEV------NATAVLWPSQVGTLTYVWWYGNNTEPLI---TLEGSISFRFTSEGMN- 951

  Fly  2360 PRDLTIDMQTHDIYWVDSKLDTIQ------KISYNGANRKIIRRDLPNPMGIAVYLNDVYWVDRN 2418
              .:|:.:...:....|:|...:.      ::|:: .|......|:|.            | .|:
Human   952 --TITVQVSAGNAILQDTKTIAVYEEFRSLRLSFS-PNLDDYNPDIPE------------W-RRD 1000

  Fly  2419 LMTVFKAS-------------------------------KHSANETATSVRTNLEKLRDIAIYNI 2452
            :..|.|.|                               :..|.|...|. .:||::.::.|:.:
Human  1001 IGRVIKKSLVEATGVPGQHILVAVLPGLPTTAELFVLPYQDPAGENKRST-DDLEQISELLIHTL 1064

  Fly  2453 N-NQPQDDTNP-------CAHLGNGGCDQLCFSFPPDGGAS----------GTSGGRNFRCECAT 2499
            | |....:..|       .|||.......|.   |...|::          |          .|.
Human  1065 NQNSVHFELKPGVRVLVHAAHLTAAPLVDLT---PTHSGSAMLMLLSVVFVG----------LAV 1116

  Fly  2500 GKLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNL 2544
            ..:...:||...:|.|.......|...::...||...|..|.|.|
Human  1117 FVIYKFKRKIPGINVYAQMQNEKEQEMISPVSHSESRPNVPQTEL 1161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531 11/25 (44%)
LY 1667..1711 CDD:214531 6/43 (14%)
Ldl_recept_b 1690..1728 CDD:278487 4/37 (11%)
LY 1712..1754 CDD:214531 2/41 (5%)
LY 1986..2037 CDD:214531 12/61 (20%)
FXa_inhibition 2151..>2179 CDD:291342 8/48 (17%)
LY 2259..2305 CDD:214531 7/46 (15%)
Ldl_recept_b 2326..2366 CDD:278487 10/41 (24%)
LY 2352..2392 CDD:214531 5/45 (11%)
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
SORCS1NP_001374485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..69
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..150
VPS10 196..793 CDD:214740 124/653 (19%)
BNR 1 208..219
BNR 2 256..267
BNR 3 492..503 2/10 (20%)
BNR 4 569..580 2/12 (17%)
BNR 5 611..622 2/10 (20%)
PKD 807..880 CDD:395646 18/94 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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