DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and lrp2b

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_021335953.1 Gene:lrp2b / 101886177 ZFINID:ZDB-GENE-111115-1 Length:4577 Species:Danio rerio


Alignment Length:4774 Identity:1915/4774 - (40%)
Similarity:2683/4774 - (56%) Gaps:383/4774 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 FRCNNGKCISHHWVCNYQKDCDDGEDEMQSCPPPECETPQLNC---------------------- 204
            |:|:||:||:..|.|:..|||.|..||: :||.|.|.:.:..|                      
Zfish     5 FQCSNGQCINQDWKCDGTKDCTDNSDEL-NCPLPTCSSQEFKCLTGGECIPLEFVCDGEADCADG 68

  Fly   205 --------------GQYTFNKTYCIPPHYRCDMIEDCEDKSDEAQCTYRKCQHTDLFCNTPTGAP 255
                          .|:|..:..|||..|.||.:.||.|.|||..|.|..|  |:..|       
Zfish    69 SDEQRTCSGQTCSPDQFTCREGQCIPKQYNCDHVPDCVDNSDENNCNYPAC--TEKTC------- 124

  Fly   256 AEGARLTGPCVPKEKRCDGYLDCRTGRDEVGCSGVACRLDQFRCANGLKCIDAALKCNHRDDCGD 320
            |.||     |....:.|:|.||||.|.||..|:. .|:..||.||||. ||.....|:|.|||||
Zfish   125 ANGA-----CYNNAQHCNGILDCRDGSDESNCTR-HCQSHQFECANGF-CIPMPFVCDHWDDCGD 182

  Fly   321 NSDEQGCNFPPCHHAQFRCTNALCIPYNFHCDGYHDCADKSDEANCT--AIACPDNKHLCPRGGA 383
            |||||.|.:..|..::|.|:|..|:|..:.|||.:||.|.|||..|.  ...|...:..||    
Zfish   183 NSDEQNCEYRTCSGSEFACSNGRCMPQQWVCDGINDCGDFSDENGCDPGIRDCYPGEWPCP---- 243

  Fly   384 SGTPKCILKSQLCDGKRDCEDGSDEET-----NCSIASCPALSCEFKCGPSLTGGVCYCKPGQSL 443
             |:..|:..:::||...||..|:||..     .|.:..|.|||||::|.|:..||.|||..|.::
Zfish   244 -GSSLCVPVNKVCDEHPDCPGGTDESNATAHLTCDLHQCSALSCEYRCHPTPQGGACYCPDGFTV 307

  Fly   444 APDNRTCVDLDECAEWGHCDQLCTNTLGSYTCQCAQGYTLINDSKCIAPDANNL-QLIFAHDRAI 507
            |.|:|||||.|:|..||.||..|.:..|::.|.||.||.|.....|.|..:..| ||||...|.|
Zfish   308 ANDSRTCVDYDDCKIWGICDHFCEDRPGTHHCSCADGYFLEQGHVCKANISGGLPQLIFTDGRDI 372

  Fly   508 MRMLPHGSEPKILANATA---AAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNK------AVSPF 563
            .....||...::|..:..   |.||.:::....::|:|..::||.|:..|..:|      ||...
Zfish   373 KMADIHGRFIRLLVQSDGKGYAVGVGYNWHTQRVFWTDTSSQKVFSINFDGSDKMEVLSEAVHNA 437

  Fly   564 DQTLPGTWAPVALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAGLM 628
            ..          :||||:..|:|:.:...::|:..:..|.....::..||.:|..||||||.|.|
Zfish   438 QN----------VAVDWINFKLYLVEERVERIEACDYDGGNRVTLIAENLVTPHGLALDPTVGYM 492

  Fly   629 FVADGG------QVLRAHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLDYIESVDYEGA 687
            |..|.|      ::.||.|||::...:|.......:|:|:|:::|||:|.||..:.:|:|.|.|.
Zfish   493 FFTDSGDNTDDVKLERAFMDGSNRFDLVRTRLGSPTGITLDLVTKRVYWTDSHFNLVETVTYSGL 557

  Fly   688 HRVMVLR-GQQVPSPSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTYKAKDIREPKGIIAV 751
            .|..||. |.|||.|..:::|||..::||..|.|::..::|.|.   ..|:..:....|..|:..
Zfish   558 DRKTVLNGGHQVPHPFGISVFENHAFFTDWVKMGVIRTNRFNGS---DPTFLYRSTNRPGQIVVS 619

  Fly   752 HALSQPRVSNPCGNNNGGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLKLCKPVSEFLMYSQ 816
            |...||.|.||||.:||||..:|:::. :....|||:||.|..||.|:.|...|..:.::|:.:.
Zfish   620 HPALQPFVINPCGRHNGGCQQICLLSH-RTDNDGLGYRCMCRLGYDLQDDRHSCFKIKDYLLVAY 683

  Fly   817 QRFIKGKVLEPVIEGFSDAIMPVVSRRARF--VGLDFDARDEFIYYSDVLQDVIYRVHRNGTGRE 879
            .:.::|..|.  :....|..:|:......|  .|:::||..|.::|:|.::.:||:.:.|||..:
Zfish   684 AQAVRGIPLN--VSSQEDVTLPLSGLADTFSGSGVEYDASVESVFYNDRMRQLIYKSNINGTSHK 746

  Fly   880 IVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVT--HRRTLLKNLKRPRAIVVHPNRG 942
            ::...:...||.:|.||.||.|::..|   |...:....||  .|:.::|||..||.|.|||:.|
Zfish   747 VLTGYRVGAVESMAYDWTSKILFWTSS---TYRSVCAFKVTDGSRQDIVKNLIYPRGIAVHPSAG 808

  Fly   943 FIFFSEWDRPANITRANTDGSGLLVFKNVTLGWPNGLSIDFKEDRVYWCDALLDHVQHANLDGTD 1007
            ::|:|:|.|||.||||.||||..:...|.||||||||::|:..||:||.||.||.::|.::||.|
Zfish   809 YLFWSDWYRPAVITRAYTDGSNAVPLINTTLGWPNGLAVDYMMDRLYWVDAQLDRIEHVSIDGFD 873

  Fly  1008 IKTVNS-RLVRHPFSIVIHNDWMYITDWRLDAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHE 1071
            .:..:| ..:.||||:.||.|.::::|||.:::.|:.|..| .:.:|:|: ..:.:..:|.||.:
Zfish   874 RQAFSSIGQITHPFSLTIHTDHLFVSDWRTNSVFRMRKRDG-GDNIMLRK-GISGIMNIKAYSAD 936

  Fly  1072 VQRIADTQPCHRNNGGCQKICFAVPIGASNGTDGVTTSSPSFGRLQSR-CSCPYGERLADDQVSC 1135
            :|.:..::.....||.|...||..|                   ..|| |.||:|.:|.::|..|
Zfish   937 LQDLFKSRCNMIPNGRCSHFCFPTP-------------------ASSRVCGCPFGMKLQENQRDC 982

  Fly  1136 IPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCDGDDDCLDNSDEEQNCTKP--TCGSNEFQCRS 1198
            :.|.|..||...| ..:.|.|:..||:|.::.|||.:||:|.:| |.|||.|  ||....|.|.:
Zfish   983 VKDDSEPPPDDNC-GDYAFPCDGGRCVPNTYRCDGVNDCVDKTD-EVNCTLPGATCSPYAFTCGN 1045

  Fly  1199 GRCIPQNFRCDQENDCGDNSDEQEC---GNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEG 1260
            ..|||..:|||..:||||.|||..|   |..||.:|||||.||.|||..|.||:.|||||.||| 
Zfish  1046 KHCIPARWRCDGHDDCGDGSDETNCPTRGPTTCSSSQFACTNGNCIPKTWVCDAFNDCGDGSDE- 1109

  Fly  1261 DFCAEK--TCAYFQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCVE 1323
            ..|...  ||....|.|| ...||..|:|||||.||.|..||||| ..:|...:|.||...|||.
Zfish  1110 RHCNSSITTCQPGFFLCP-DHRCIYNSYVCDGDQDCLDGSDEKDC-VYTCGTYEFACASGDQCVS 1172

  Fly  1324 ESYKCDGIPDCNDGSDEVGCPSMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQD-C 1387
            :||:|||:.||.|.|||.|||:..|..|: :..|:|:..|||||..|.|||..||.|.|||.: |
Zfish  1173 QSYRCDGVYDCKDHSDESGCPTRRPGLCH-DNEFQCQVDGFCIPKEWECDGHPDCVDGSDEHNGC 1236

  Fly  1388 GQITCAQNFFKCNNTNCVFKAYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQWQCPGVSERCVN 1452
            ...||:...|:|.|.|||.|.::|||::||.|.||   |..|..|||.||.|||.|| ..:.|:.
Zfish  1237 PPRTCSSVQFQCANGNCVSKNWVCDGENDCRDMSD---ETNCPTPPFSCPSGQWLCP-TDQVCIM 1297

  Fly  1453 ITSVCDDTPDCPNGSDEGEGCDLAECEHQAGQCSSFCQKTPNGALCVCPPGSEIGEDGYTCIDSN 1517
            ...|||...|||||:||...|:..:|:...|.||..|.:.|.||.|.|.||.::..|..||.|.|
Zfish  1298 NAQVCDGQRDCPNGADESPICNEDDCKVNNGGCSHGCIQGPFGAQCTCDPGFQLLNDSKTCDDIN 1362

  Fly  1518 ECDPPGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTCKAVNHTAAFLIISNRHSIL---------V 1573
            ||..||.|||.|.|.:||:.|.|.|||.|||:..||:|.:...|.|:::.|..|:         :
Zfish  1363 ECLIPGFCSQTCFNERGSFRCYCEDGYQLEPDGRTCRATSPGNALLLVARRSQIIGNRINFWPPI 1427

  Fly  1574 ADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKI-SRLDRGMEPQEIINTGLDLVEGLA 1637
            ......|:..|.:..:||        ...::|.|...|.| |....|.:.:::.::||.:.|.:|
Zfish  1428 ISPIVSGMSIVAVDFDNV--------NKRVYWGDSSDKMIYSSFQNGTDKKQVFSSGLMVPESIA 1484

  Fly  1638 YDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMCIDPSPGARWIFWTDWGENPRVE 1702
            .||:.:|:||.||.:..|||:..:|..|.:|:.:|:|.|||:.:||......:||:|||:|||:|
Zfish  1485 VDWVGRNIYWTDSVMQNIEVATLDGHFRKILITKNVTSPRGLVLDPRNHTNLMFWSDWGQNPRIE 1549

  Fly  1703 RIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHP 1767
            :..|||..|:.|:.:|:|||||||||..|:||||.|:.|.:||:|.|:|..|.||.||...|..|
Zfish  1550 QASMDGLGRRAIVTSKVYWPNGLTLDYTTRRVYFVDAYLKYIDYCDYDGKNRHQVFASDIVLQQP 1614

  Fly  1768 HSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCAGSRCQ 1832
            |.:::|||.::|:|...::::..|||.|.|.|.:...:.|.:.|.:.|...||:..|||..:.|.
Zfish  1615 HGITIFEDNIFWSDSYTSQIMRTNKFHGGNITTLLTGVYQCMGIVMDHPIKQPIAFNPCENNPCS 1679

  Fly  1833 HLCLLSPSAPEGYSCKCRPGFKLLSEGR-CIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVI 1896
            .|||||...|..|.|.|:.|:.|.|:|| |.::|.||||||:.|.|:.:|||..|....|:||:.
Zfish  1680 QLCLLSTLRPRYYRCDCQSGWILASDGRTCTKDETPFLMVVRDTVIMGIPLNPNDTSNNAMAPIS 1744

  Fly  1897 GIESSTGLDFDRKGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGIVGAPYTIAFDWLG 1961
            ||.....:|||.:.:.:|||||      ...||.:...|.|:|.|  ....|:|:|..:||||:.
Zfish  1745 GITQGRDIDFDDREQFVYWVQG------TGAIYRSKTDGANRTQF--APAAIIGSPSGLAFDWIT 1801

  Fly  1962 RNLYIGNRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDEGV-LEVP 2025
            |.:|..|.....||.:||||.|.||..|:.|.|.|....:|..|||||..|||||.|.|. ..||
Zfish  1802 RIMYYTNPTIKAIEVIRVDGSQHYRKTIITNTGKPEGAGQPIGIALDPARGKLFWTDRGSDSGVP 1866

  Fly  2026 IKIGRVDMNGQNPIVVFQ-EFAHPESLAVDTEKKMVYYSASNPAVI--GVMDYNGDDHTLILMKD 2087
            .||...||:|.|...::. .....|.:|.|.|.:.:|:......:|  |.||  |.....|:...
Zfish  1867 PKISSADMDGGNVKNLYTGNLVKVEFIAADIEARKIYWGVHQTGMIECGTMD--GASRVTIVSGL 1929

  Fly  2088 SHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMIYKK--RALMQHP 2150
            |||.    .:.:..:.|||.|..:|.|.|:|...|.:...:..:.:.|||:.::.:  .|...:.
Zfish  1930 SHPW----GITVYQNYLYYTDLDFEVIERVDKNTGADMVVMRSSMAGLRSVKVHARDNSAGTTNA 1990

  Fly  2151 CQTNNGGCKHLCIPGPGATRTCACGIGY-RKENEINCVAYKIFAVVSQLDMIRGYSL--SDSSEA 2212
            |.||||||.|||:|.|...:||||..|: ..::..:|..|..:|:||....|||:.:  ||.|||
Zfish  1991 CSTNNGGCPHLCLPKPQGQKTCACTTGFIPSQDGSHCEQYDSYAIVSSSKFIRGFHINSSDHSEA 2055

  Fly  2213 MVPISGPGHHIL-HVDVMYREQWIYWAEYNRGY--WNGIFRSRPNGTDLQHVVKDGIGSNGIRGL 2274
            |||:....:.|: .:|:.....::||.: |..|  :.||:|::.:|:....|:.. :|:..|:||
Zfish  2056 MVPVGANTYSIIDKLDMHIASGFLYWTD-NSTYSSYRGIYRTKTDGSRYSTVISQ-LGNGRIQGL 2118

  Fly  2275 TIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRI 2339
            .:||:|||:||||.:..:.|:||..|:.|.:.:|:|::.|.|::|||:|..|||:|.|.||.|:|
Zfish  2119 AVDWIAGNLYFTNKFTTQTYIEVLRLNTSIQLILLKSSADRPQDLAVSPKLRLLFWTDAGQSPKI 2183

  Fly  2340 GKALLDGSKWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISYNGANRKIIR--RDLPNP 2402
            ..|||||:..|.|.:..:|.||.||||.....:||||..||.|.:::.:|:.|:|:|  ...|.|
Zfish  2184 ESALLDGTNRTVLASESLSSPRGLTIDYTNDFLYWVDDTLDMISRMAPDGSQREIVRFGSRYPAP 2248

  Fly  2403 MGIAVYLNDVYWVDRNLMTVFKASKHSAN-ETATSVRTNLEKLRDIAIYNINNQPQDDT----NP 2462
            ..:|::...:.||||.|..:|:|||...| :|...:|..::.|.|:|:::.:.||....    ||
Zfish  2249 YSVAIFGEYMLWVDRKLGKLFQASKVPGNTDTPEVIRDGIDDLTDVAVFDSHVQPTSANLVGFNP 2313

  Fly  2463 CAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCECATGKLSADERKCEV-VNEYLVFATRTEIRA 2526
            | |..||.|.|.||:.|..         :..:|.||.|.|.::...|.. ::|||:|.|...:.:
Zfish  2314 C-HDDNGRCQQFCFALPDQ---------QEPKCACAHGSLLSNGVSCGFGLDEYLIFTTDYSVSS 2368

  Fly  2527 VNLDPHSTEVPFTPLTNLTNVVGLDFDFAHNRMLYTQI----RPWAKIAYTKANKPGHDDITVVL 2587
            :.|||....|||........|:.::|||...|:.:||.    |  :||.|..........:|:..
Zfish  2369 MRLDPEDHSVPFPTFNMGYGVLAIEFDFQDKRVFFTQYVGLGR--SKIGYIITTSSTSPPVTIAS 2431

  Fly  2588 NKGINPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGSELVMIARVERPRAIVLDPCNGTLFFTDWG 2652
            :.. :|||:||||..:::|:||..|.|:.:|.:||....:||..:||||||:|||.|.|::||| 
Zfish  2432 DLD-DPEGLAYDWVHKRLYFTDYYNRSVQSMGIDGQNRSLIAHGDRPRAIVVDPCYGYLYWTDW- 2494

  Fly  2653 RFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLV 2717
              |:..||.|.|:.|:.:..:::..||||:.|::||:||.|||.|:..:|||||.|.|:|||:::
Zfish  2495 --GSPAKIERATLGGNFRIPVINTSLSQPNALSLDYEERLLYWADSTLDKIERSSLTGENREVIL 2557

  Fly  2718 AATIYPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNP 2782
            ..|.||||:|||:..|||||...|.||||.|..|:.:..|...|:..|.||.::|:.||:...:|
Zfish  2558 TQTQYPFALTVFQQDIYWTDWNTRIVYRASKDDGSGLTIMATDLQYRPNDIHVFSASRQESCSSP 2622

  Fly  2783 CRINNGGCAQSCHPAPNGKAECKCDDSTK--VVNEGRMCAPRN-NTCEASKFYCKNGRCISRMWS 2844
            |::.||||:..|.|.|.| .||:|..:..  :.|||:.|.|.| ..|.|.:|.|.:|||:|:.:.
Zfish  2623 CQLFNGGCSHVCVPGPAG-PECQCPSTGNWYLANEGKDCIPDNGQRCHADQFTCLDGRCLSQNFK 2686

  Fly  2845 CDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPC-VD 2908
            |||..||.|.|||....||:|:|||.||.|:||.|:...:.||:.|||.|.|||.||.:|.| ..
Zfish  2687 CDGYRDCLDGSDELERVCAFHTCSPTEFTCDNGGCVPLYYVCDYTNDCGDNSDEHGCPFPTCNPS 2751

  Fly  2909 GEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGD 2973
            .||||||||||..|.||:|:|||:||.|:||.:  || :.||....:||:.||||:....||||.
Zfish  2752 TEFTCANGRCISAAYVCDGINDCRDNGTTDEVN--CP-DRTCAPGLVKCDTTNICIPSSSLCDGH 2813

  Fly  2974 NDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGD 3038
            |:|||||||:||.|..|||..:.|||.:.:|||..|.||...||.||.||||. |:....||...
Zfish  2814 NNCGDNSDENPLFCAGRTCSADEFRCDSGKCIPQFWVCDRISDCLDGTDEPPT-CEDHIYTCSPQ 2877

  Fly  3039 LFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQ--RAQCIPKKW 3101
            .|.|.|||||.:.::|||:|||.|||||....||..|.|: ..:|||   .||.  ..:|||..:
Zfish  2878 QFNCANGNCIQQSWVCDGNNDCGDNSDEAQELQCGSRTCN-PGDFTC---PSWYPGSPRCIPLSY 2938

  Fly  3102 ICDGDPDCVDGADENTTLHNCATQQPCGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSK 3166
            :|||:.||||.|||   |||| ..:.|..:.|.|.|||||...:.||..||||||:||   .|..
Zfish  2939 VCDGEKDCVDAADE---LHNC-PNRTCHLNEFACANGRCILLPFHCDRVNDCGDGSDE---TNCI 2996

  Fly  3167 YKTCSAQEFTCQNFKCIRNQSRCDGEDDCGDHSDEVG--CAKENITCPQGQFACTNGQCIDYNLV 3229
            |.|||::||||||..||.:...|||..||.|.|||:.  |.....||..|.|.|.:|:|||.:.|
Zfish  2997 YNTCSSREFTCQNGVCIPSTYVCDGYIDCQDGSDELEGLCRTPEPTCAPGDFMCNSGECIDIHKV 3061

  Fly  3230 CNKYPDCADESDEPAHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECL 3294
            ||:..||:|.|||.. |.::||....|:||.|.|:||.|||||.|.|||:|:.|||||.|:|||.
Zfish  3062 CNQQRDCSDNSDEKG-CGINECTNPAIHQCAHNCIDTQTGYYCSCREGYRLMPDGKACEDIDECK 3125

  Fly  3295 EQPGACSQHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNL 3359
            |.||.|||.|.|..|.|||||...|. |:.|..||::...|.|:|:::|:||:||::..|...::
Zfish  3126 EVPGVCSQVCENAVGSFYCKCAPGYL-REPDGRTCRQNSGIAPYLLYSNRYYIRNLTAVGSSMSV 3189

  Fly  3360 MHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWV 3424
            :.|.|.||||||||..|:.:|:.||....|.|.......      ||.::::|..|.||:|:|||
Zfish  3190 VLQGLTNVVALDFDTTEKRLYWVDVGTLRIERINLDGTG------REVIMQNDLGGAEGLAVDWV 3248

  Fly  3425 GRKLYWLDRHSKNLDVSELDGSKRKTLRSGVVD---------PRAIVVHPGIGYLYFTSWHLQAY 3480
            ||||||.|...|.:.||||||..||.|....||         |:|:.|:|..|:||:|.|..:|:
Zfish  3249 GRKLYWADATMKAIHVSELDGRYRKKLLKDCVDTNSTYCFASPQAVAVNPKYGWLYWTDWGRKAF 3313

  Fly  3481 IAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSKV 3545
            |.:.||||:..|.::...  :.||:||:|||..::|::|||||:::.|||::|::||..::|| :
Zfish  3314 IGRAGMDGTQASALITTK--LVWPHALTIDYTNNKIFFADAHLNFLDYADMDGQNRHRAITGS-L 3375

  Fly  3546 PHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQLPYTNPCGTN 3610
            ||.:||:||:|.:||:|||...|.||:|:.|||..|:.|.||||.|:||.||.||....|||..:
Zfish  3376 PHAYALTLFEDLVYWTDWNTHTIERAHKYTGANRVVMGNNTHRPNDIHIYHPYRQPHSENPCNDH 3440

  Fly  3611 NGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFY-LARDMK-TCVANCTAGQHLCGGR 3673
            ...|||||||.|               |....:|.||:.|. ||...| .|||:|::.|..||. 
Zfish  3441 YLTCSHLCLIGP---------------GGTEARCECPDHFIGLAIGFKIQCVADCSSTQFRCGD- 3489

  Fly  3674 DEKCIPWFWKCDGEKDCKDGSDEPATCAPRHCRAGTFQCKNTNCTPSATICDGVDDCGDRSDEQN 3738
            :|||||.:|||||:.||.||||||.||.|.:|:.|.|||::.|||....:|||..||.|.|||..
Zfish  3490 NEKCIPIWWKCDGQSDCGDGSDEPQTCPPHYCKTGQFQCQDGNCTNPFFLCDGHKDCFDGSDEDA 3554

  Fly  3739 C---DLPCPLSDFKCKSSGRCILDSWRCDGDADCKDGSDEDPAVCFKRTCDPKTEFSCKNGRCIP 3800
            .   |..|..:.|:||:. .||..:|.|||..||.|||||:...|..:||.| .:|.||.|.|||
Zfish  3555 ALCSDHRCTENQFQCKNK-HCIPITWHCDGVVDCSDGSDEETDSCIDKTCKP-GQFQCKKGGCIP 3617

  Fly  3801 QLWMCDFDNDCGDDSDEPAYMCRQRNCTTGWQRC------PGQSNYRCIPKWLFCDGKDDCRDNS 3859
            |.::||..|||||:||||..:|...:     .:|      |.:.||||||.|..|||.:||.|||
Zfish  3618 QSYVCDAQNDCGDNSDEPYEVCMGPD-----YKCDPDTEFPCKGNYRCIPLWAVCDGTNDCLDNS 3677

  Fly  3860 DELPENCPK--CNPETDFKCGNNRCIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGN 3922
            ||  ..|.:  |:|..||:|.|:||:|.:|.||.::||||.|||..  |:.  |.|||||:||.|
Zfish  3678 DE--NTCHELTCDPLGDFRCDNHRCVPIRWRCDGSNDCGDGSDERN--CEP--RPCSESEYRCDN 3736

  Fly  3923 GKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGTFQCASGHCIASYFRCDGDRDCRDMSDEVGCP 3987
            .:||...|.|||::||||||||..||...|:.|||||.|||||....:|:|..||.|.|||..||
Zfish  3737 QQCIPGAWVCDHDNDCGDNSDERDCELRTCRPGTFQCTSGHCIPEALKCNGYADCLDFSDESTCP 3801

  Fly  3988 PRFPGGRYCPESRFQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCSNERCVA 4052
            .|:||||:||..:|||||.|||:...:|||.:||||.|||..|:|.:..|:...:|:|.|..|:.
Zfish  3802 TRYPGGRWCPAHQFQCNNKLCVNQQWVCDGFNDCGDRSDEQLSLCWNITCEMPTKFRCDNGYCIY 3866

  Fly  4053 RYQICDGVDNCGDGSDENNMTLCASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGDASDELGC 4117
            ...:|:..|:|||||||...........|| ...:::|:|.||:....|||.:::|||.:|||||
Zfish  3867 SGLMCNQKDDCGDGSDEKEDQCQEPTLAPC-TPNEFKCSNGHCVPLPYVCDHNNNCGDLTDELGC 3930

  Fly  4118 H--HTSSCSEANRGGCQQHCHNLTDGGYICTCYPGYIIAADNKKKCSDVDECLTRQHTCSHQCHN 4180
            :  |..:|.|..   |:..|.||...|:||:|.|||.:..||...|:|:|||| ...||...|.|
Zfish  3931 NFGHDRNCDEKL---CKHECTNLNGTGFICSCRPGYAVDPDNTFLCNDIDECL-EYGTCPQACMN 3991

  Fly  4181 LNGTYSCSCREGFHLTDGASGVCRAEKEDVILLFVNGQEIRGLNWHKSEEFAVIAAEKRIEALDY 4245
            ..|:|.|.|.:|:... |....|.||....:||......||..|....|....:..|:||.||||
Zfish  3992 TKGSYHCDCAQGYRKA-GTGNQCEAEGPGPLLLLPENIRIRRYNLQTEEYHDFLQEEERIVALDY 4055

  Fly  4246 DAQQ-----QIVFWA----DSYDKTIKRSYMVNAIDGRAKIGFAQDLNMKGGSKPTAVAVDWLAS 4301
            |...     .:|::.    .:....|||:::.:..|....|..|.:|::|..:||..:||||:..
Zfish  4056 DWDHNNTGFSVVYFTVEGRGALPGAIKRAFLPDVDDHNNNIAAAVELDIKYITKPYGIAVDWVGR 4120

  Fly  4302 NLYWTEMDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAVNPQLGRIYWSDAGSAPKIEVS 4366
            ||||.:....      |:.||..|||||:.::...||.|.|:|:||:||.:||.|.|:.|:||.|
Zfish  4121 NLYWADAQLK------RLEVAMLDGRYRKHLIKTDLEAPNSVALNPRLGMLYWIDNGNTPRIECS 4179

  Fly  4367 WMDGSKRRPLITEMIRHPAGLTIDYSQDHIIYWVDTKLNAIESMRADGSRRKAIVRGDQLRHPVS 4431
            |:||.:|:.|:...:..|.||:||::....|||.|.|.:.|||:..||..||..|..| :|:|.|
Zfish  4180 WLDGQERKVLVNNGLGWPTGLSIDFTNGDRIYWSDAKESRIESILPDGQNRKTSVFID-VRNPFS 4243

  Fly  4432 LDLFESNMFWMTRDTGELVRQDKFGRGVQVVLHRYIVNP--SGLKVYHDKRYNT-SLPNPCDNST 4493
            :::||.:::|.|::.||:.||||||:|.:..|  .:..|  :.:.:|..::||: :|.||| ..|
Zfish  4244 VNVFEDHVYWSTQEKGEVFRQDKFGKGTKTRL--LVTGPWLTQINIYQQQKYNSIALKNPC-KGT 4305

  Fly  4494 CSHLCLLVPGGHRCACPDASGPPPSHRSTAEVICNAAAEHPRPA-PRICPCQNGGLCKEDAQGEL 4557
            |||||||.|||:.||||:.:...|. .|||   |:|..: |.|. |..|.|:|||.|..| ..:.
Zfish  4306 CSHLCLLRPGGYTCACPEGTSFFPG-SSTA---CDAGID-PEPTMPPPCQCKNGGTCYFD-DNKA 4364

  Fly  4558 LCECRTQFVGEHCETSTMGAFGHGDANVTAVVVPIMVILLVMMAAAGAWYVIRKRPFGK----LA 4618
            ||.|.:::.|:.||||..|..      .|:|.:.:.|..:|.:......|...|:...|    ..
Zfish  4365 LCICPSEWKGDFCETSVYGVV------TTSVAIALGVTAVVALFLGCLIYSAHKKENIKNRLNNI 4423

  Fly  4619 RMPAMTSSQSVTFRHGSNVEFN---ESGFPGASAPGAGDVAPIEGYNLQTVNANKARDFANPMY- 4679
            .:|...|:...||..|::..|:   ||.....|.|.......:|...:       .|:|.||.| 
Zfish  4424 NLPVNVSNFMPTFWRGNSERFSNSPESENDSNSLPKEESSTSVEVEKI-------GRNFENPAYA 4481

  Fly  4680 DAVQSGTTADPGMGNGSGIYDVPGEPSAK---------VKSMGHHAGGSFTEPASAIIAPSSITH 4735
            |..||...|  .....:.:.:.|.:.|.:         |.:..|.|    ..|..|...|.:...
Zfish  4482 DDTQSCPAA--STATATSVINGPAKESVENPLYAAEISVVTQPHDA----ATPVKADATPVNTES 4540

  Fly  4736 KASPQLQLRTRELDPSADTGKDTQFLVEE 4764
            :.:...:|:: |:|  .|...|....::|
Zfish  4541 QKADTSKLQS-EVD--IDNVFDNPLYMDE 4566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060 13/26 (50%)
LDLa 204..236 CDD:238060 15/67 (22%)
LDLa 292..327 CDD:238060 21/34 (62%)
LDLa 332..366 CDD:238060 15/33 (45%)
LDLa 371..412 CDD:238060 12/45 (27%)
vWFA <447..488 CDD:294047 19/40 (48%)
NHL 573..>716 CDD:302697 53/149 (36%)
NHL repeat 573..610 CDD:271320 8/36 (22%)
NHL repeat 616..654 CDD:271320 18/43 (42%)
NHL repeat 657..693 CDD:271320 14/35 (40%)
FXa_inhibition 763..805 CDD:291342 17/41 (41%)
LY 922..964 CDD:214531 24/41 (59%)
LY 973..1007 CDD:214531 19/33 (58%)
Ldl_recept_a 1188..1223 CDD:278486 17/34 (50%)
LDLa 1227..1259 CDD:197566 21/31 (68%)
LDLa 1268..1303 CDD:238060 18/34 (53%)
LDLa 1308..1343 CDD:238060 18/34 (53%)
LDLa 1356..1387 CDD:238060 17/31 (55%)
LDLa 1391..1423 CDD:197566 16/31 (52%)
LDLa 1435..1469 CDD:197566 16/33 (48%)
FXa_inhibition 1478..1513 CDD:291342 13/34 (38%)
FXa_inhibition 1522..1553 CDD:291342 17/30 (57%)
LY 1625..1665 CDD:214531 15/39 (38%)
LY 1667..1711 CDD:214531 20/43 (47%)
Ldl_recept_b 1690..1728 CDD:278487 22/37 (59%)
LY 1712..1754 CDD:214531 23/41 (56%)
LY 1986..2037 CDD:214531 25/51 (49%)
FXa_inhibition 2151..>2179 CDD:291342 17/28 (61%)
LY 2259..2305 CDD:214531 19/45 (42%)
Ldl_recept_b 2326..2366 CDD:278487 21/39 (54%)
LY 2352..2392 CDD:214531 16/39 (41%)
NHL 2579..>2711 CDD:302697 57/131 (44%)
NHL repeat 2593..2622 CDD:271320 13/28 (46%)
NHL repeat 2634..2678 CDD:271320 19/43 (44%)
LY 2671..2713 CDD:214531 20/41 (49%)
LDLa 2867..2901 CDD:238060 18/33 (55%)
LDLa 2906..2941 CDD:238060 23/35 (66%)
LDLa 2950..2983 CDD:238060 18/32 (56%)
LDLa 3034..3066 CDD:197566 18/31 (58%)
LDLa 3080..3115 CDD:197566 16/36 (44%)
LDLa 3128..3159 CDD:238060 16/30 (53%)
LDLa 3170..3204 CDD:238060 19/35 (54%)
LDLa 3210..3242 CDD:197566 16/31 (52%)
cEGF 3269..3292 CDD:289433 15/22 (68%)
vWFA <3284..3324 CDD:294047 24/39 (62%)
LY 3362..3394 CDD:214531 16/31 (52%)
LY 3406..3448 CDD:214531 23/41 (56%)
LY 3498..3536 CDD:214531 17/37 (46%)
LY 3536..3578 CDD:214531 21/41 (51%)
FXa_inhibition 3607..3659 CDD:291342 17/53 (32%)
LDLa 3663..3696 CDD:238060 19/32 (59%)
LDLa 3705..3739 CDD:238060 17/33 (52%)
LDLa 3743..3775 CDD:197566 15/31 (48%)
LDLa 3784..3817 CDD:197566 19/32 (59%)
LDLa 3827..3861 CDD:197566 17/39 (44%)
LDLa 3871..3901 CDD:197566 16/29 (55%)
LDLa 3913..3947 CDD:238060 22/33 (67%)
LDLa 3952..3986 CDD:238060 19/33 (58%)
LDLa 3996..4027 CDD:197566 18/30 (60%)
LDLa 4043..4071 CDD:238060 13/27 (48%)
LDLa 4086..4117 CDD:238060 13/30 (43%)
EGF_CA 4163..4194 CDD:214542 14/30 (47%)
NHL 4276..>4426 CDD:302697 63/149 (42%)
NHL repeat 4291..4336 CDD:271320 17/44 (39%)
Ldl_recept_b 4350..4390 CDD:278487 17/39 (44%)
NHL repeat 4376..4422 CDD:271320 18/45 (40%)
lrp2bXP_021335953.1 LDLa 2..34 CDD:238060 14/29 (48%)
LDLa 38..71 CDD:197566 2/32 (6%)
LDLa 80..114 CDD:238060 14/33 (42%)
LDLa 123..151 CDD:238060 14/39 (36%)
LDLa 155..189 CDD:238060 21/34 (62%)
LDLa 194..228 CDD:238060 15/33 (45%)
LDLa 235..269 CDD:238060 12/38 (32%)
FXa_inhibition 324..>347 CDD:317114 10/22 (45%)
LY 429..469 CDD:214531 10/49 (20%)
LY 471..516 CDD:214531 19/44 (43%)
LY 519..559 CDD:214531 14/39 (36%)
FXa_inhibition 631..672 CDD:317114 17/41 (41%)
Ldl_recept_b 808..848 CDD:278487 24/39 (62%)
LY 834..874 CDD:214531 21/39 (54%)
FXa_inhibition 950..982 CDD:317114 14/50 (28%)
LDLa 995..1029 CDD:238060 14/35 (40%)
LDLa 1036..1070 CDD:238060 16/33 (48%)
LDLa 1078..1112 CDD:238060 22/34 (65%)
LDLa 1119..1153 CDD:238060 18/34 (53%)
LDLa 1157..1192 CDD:238060 18/34 (53%)
LDLa 1200..1234 CDD:238060 18/34 (53%)
LDLa 1241..1275 CDD:238060 17/36 (47%)
LDLa 1282..1314 CDD:197566 16/32 (50%)
FXa_inhibition 1323..1358 CDD:317114 13/34 (38%)
EGF_CA 1360..1398 CDD:214542 21/37 (57%)
YncE 1388..>1660 CDD:331368 103/279 (37%)
LY 1470..1512 CDD:214531 15/41 (37%)
Ldl_recept_b 1535..1575 CDD:278487 22/39 (56%)
LY 1559..1601 CDD:214531 23/41 (56%)
LY 1789..1824 CDD:214531 15/34 (44%)
LY 1837..1879 CDD:214531 20/41 (49%)
LY 1922..1958 CDD:214531 12/39 (31%)
FXa_inhibition 1991..2027 CDD:317114 17/35 (49%)
Ldl_recept_b 2170..2210 CDD:278487 21/39 (54%)
LY 2195..2236 CDD:214531 16/40 (40%)
LY 2427..2468 CDD:214531 16/41 (39%)
LY 2468..2510 CDD:214531 22/44 (50%)
LY 2513..2553 CDD:214531 20/39 (51%)
FXa_inhibition 2623..2660 CDD:317114 15/37 (41%)
LDLa 2667..2699 CDD:197566 15/31 (48%)
LDLa 2709..2743 CDD:238060 18/33 (55%)
LDLa 2750..2785 CDD:238060 22/36 (61%)
LDLa 2789..2822 CDD:197566 18/32 (56%)
LDLa 2831..2863 CDD:197566 15/31 (48%)
LDLa 2873..2905 CDD:197566 18/31 (58%)
LDLa 2915..2952 CDD:197566 17/40 (43%)
LDLa 2961..2995 CDD:238060 18/36 (50%)
LDLa 2999..3031 CDD:197566 18/31 (58%)
Ldl_recept_a 3042..3077 CDD:278486 18/35 (51%)
cEGF 3100..3123 CDD:315355 15/22 (68%)
vWFA <3115..3158 CDD:320736 25/43 (58%)
LY 3189..3229 CDD:214531 16/45 (36%)
LY 3230..3272 CDD:214531 23/41 (56%)
Ldl_recept_b 3303..3341 CDD:278487 15/39 (38%)
LY 3327..3367 CDD:214531 17/41 (41%)
LY 3374..3409 CDD:214531 19/35 (54%)
LDLa 3480..3512 CDD:197566 19/32 (59%)
LDLa 3521..3552 CDD:197566 15/30 (50%)
LDLa 3561..3593 CDD:197566 15/32 (47%)
LDLa 3602..3634 CDD:197566 19/32 (59%)
LDLa 3646..3682 CDD:238060 19/37 (51%)
LDLa 3689..3722 CDD:238060 18/34 (53%)
LDLa 3727..3761 CDD:238060 22/33 (67%)
LDLa 3766..3800 CDD:238060 19/33 (58%)
LDLa 3810..3841 CDD:197566 18/30 (60%)
LDLa 3854..3883 CDD:197566 11/28 (39%)
LDLa 3896..3930 CDD:238060 14/34 (41%)
EGF_CA 3975..4014 CDD:214542 15/40 (38%)
LY 4107..4142 CDD:214531 16/40 (40%)
LY 4143..4186 CDD:214531 20/42 (48%)
LY 4187..4230 CDD:214531 16/42 (38%)
FXa_inhibition 4306..>4324 CDD:317114 14/17 (82%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593393
Domainoid 1 1.000 225 1.000 Domainoid score I2472
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 3635 1.000 Inparanoid score I8
OMA 1 1.010 - - QHG46426
OrthoDB 1 1.010 - - D1326at33208
OrthoFinder 1 1.000 - - FOG0006091
OrthoInspector 1 1.000 - - otm25674
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR22722
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4385
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1312.810

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