DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and ldlr

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_002942891.1 Gene:ldlr / 100495826 XenbaseID:XB-GENE-962372 Length:894 Species:Xenopus tropicalis


Alignment Length:772 Identity:289/772 - (37%)
Similarity:397/772 - (51%) Gaps:105/772 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly  2906 CVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPANHLKC-EKTNICVEPYWL 2969
            |...||.|.:|:|||...:|:|..:|||.  |||:.|.|.: .||.|:|..| .:.|.|:...|.
 Frog    29 CDRSEFQCGDGKCIPYKWICDGSAECKDG--SDESPETCKV-VTCGADHFSCGGRLNRCIPLLWK 90

  Fly  2970 CDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRT 3034
            |||..||.:.|||:  .|.::.|..:.|.|.:.:||...:.||.|.||.||:||  .||.:.   
 Frog    91 CDGQTDCENGSDEN--DCTRKVCADDQFTCRSGKCISLDFVCDEDLDCDDGSDE--SYCPAP--- 148

  Fly  3035 CFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPK 3099
                       .|.|.::                  ||.|                  :..||||
 Frog   149 -----------TCNPAMF------------------QCKD------------------KGICIPK 166

  Fly  3100 KWICDGDPDCVDGADENTTLHNC------ATQQPCGEDMFTCGNGRCINKGWICDHDNDCGDGTD 3158
            .|.|||||||.||:||    .:|      .|.:||....|.||:|.||:..|.||...||.|.:|
 Frog   167 LWACDGDPDCEDGSDE----QHCEGREPIKTDKPCSPLEFHCGSGECIHMSWKCDGGYDCKDKSD 227

  Fly  3159 EGKFCNSKYKTCSAQEFTCQNFKCIRNQSRCDGEDDCGDHSDEVGCAKENITCPQGQ--FACTNG 3221
            | |.|..  .||...||.|.:..||....:||.|.||.|.|||.||.  |:|..:|.  |.|.:|
 Frog   228 E-KDCVK--PTCRPDEFQCNDGTCIHGSRQCDREYDCKDLSDEEGCV--NVTKCEGPDVFKCRSG 287

  Fly  3222 QCIDYNLVCNKYPDCADESDEP-AHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGK 3285
            :||..:.||||..||.|.|||| ..|..:||.: ....|.|.|.|...||.|.|||||:|: |.|
 Frog   288 ECITMDKVCNKKRDCRDWSDEPIKECGENECMR-NNGGCAHICNDLKIGYECLCNEGYRLV-DKK 350

  Fly  3286 ACADVDECLEQPGACSQHCSNTPGGFYCKCDETYYERQNDEHT--CKRKDKIPPWLIFTNKYYVR 3348
            .|.|::|| |.|..|||.|.|..||:.|:|.|.|   |.|..|  ||....: .:|.|||::.||
 Frog   351 RCEDINEC-ENPNTCSQICINLDGGYKCECREGY---QMDPVTASCKSIGTV-AYLFFTNRHEVR 410

  Fly  3349 NMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDS 3413
            .|::|..:|......|.||||||.:|....:|:.|:|.:.|:.|...:||:  ....|.||....
 Frog   411 KMTLDRSEYTSFIPRLKNVVALDMEIASNKIYWSDLTQRKIYSASMDKADN--TSHHETVISSQI 473

  Fly  3414 HGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTLRS-GVVDPRAIVVHPGIGYLYFTSWHL 3477
            ...:|||:||:...:||.|.....:.|:..:|||||||.| .:..||.|||.|..|::|:|.|.|
 Frog   474 QAPDGIAVDWIHGNIYWTDSKFSTISVANTEGSKRKTLFSDDLAKPRDIVVDPSQGFMYWTDWGL 538

  Fly  3478 QAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSG 3542
            .|.|.|.|::|.:...::..|  |.|||.:::|....|:||.|:.|..::..|:.|::|.||:|.
 Frog   539 PAKIEKGGLNGVDRYPLVTEN--IEWPNGITLDLTNQRLYWVDSKLHSLSCIDVTGQNRITVISD 601

  Fly  3543 -SKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQLPYTNP 3606
             :.:.|.|.|::|:|.::|:|...:||..||:..|:|.|.:......|.|:.:.|.|||....|.
 Frog   602 ETHLAHPFGLTVFEDLVFWTDIENEAIFSANRLTGSNITKVAEDLLSPEDIVLYHNLRQPKAENW 666

  Fly  3607 CGTN---NGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCV 3660
            |.::   ||||.:|||.||           .|...:|.|.||||:..:|..||::||
 Frog   667 CESHHLGNGGCEYLCLPAP-----------LITSRSPKFTCACPDGMHLGADMRSCV 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060 16/34 (47%)
LDLa 2950..2983 CDD:238060 14/33 (42%)
LDLa 3034..3066 CDD:197566 2/31 (6%)
LDLa 3080..3115 CDD:197566 14/34 (41%)
LDLa 3128..3159 CDD:238060 13/30 (43%)
LDLa 3170..3204 CDD:238060 15/33 (45%)
LDLa 3210..3242 CDD:197566 15/33 (45%)
cEGF 3269..3292 CDD:289433 13/22 (59%)
vWFA <3284..3324 CDD:294047 18/39 (46%)
LY 3362..3394 CDD:214531 13/31 (42%)
LY 3406..3448 CDD:214531 14/41 (34%)
LY 3498..3536 CDD:214531 13/37 (35%)
LY 3536..3578 CDD:214531 16/42 (38%)
FXa_inhibition 3607..3659 CDD:291342 20/54 (37%)
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
ldlrXP_002942891.1 Ldl_recept_a 27..60 CDD:365841 14/32 (44%)
Ldl_recept_a 68..106 CDD:365841 16/39 (41%)
LDLa 111..145 CDD:238060 14/35 (40%)
Ldl_recept_a 149..185 CDD:365841 21/75 (28%)
Ldl_recept_a 195..231 CDD:365841 17/36 (47%)
Ldl_recept_a 235..270 CDD:365841 16/34 (47%)
LDLa 278..308 CDD:381805 14/29 (48%)
FXa_inhibition 318..352 CDD:373209 16/35 (46%)
EGF_CA 354..384 CDD:214542 16/33 (48%)
LY 419..457 CDD:214531 14/37 (38%)
Ldl_recept_b 439..482 CDD:278487 13/44 (30%)
Ldl_recept_b 486..525 CDD:278487 16/38 (42%)
Ldl_recept_b 529..569 CDD:278487 15/41 (37%)
LY 555..595 CDD:214531 13/41 (32%)
Ldl_recept_b 616..655 CDD:278487 12/38 (32%)
FXa_inhibition 674..711 CDD:373209 19/47 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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