DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and lrp3

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_009301583.1 Gene:lrp3 / 100170796 ZFINID:ZDB-GENE-080116-3 Length:824 Species:Danio rerio


Alignment Length:553 Identity:127/553 - (22%)
Similarity:193/553 - (34%) Gaps:200/553 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   959 NTDGSGLLVFKNVTLGWPNGLSIDFKEDRVYWCDALLDHVQHANLDGT--DIKTVNSRLVRHPFS 1021
            :|:..|::......|.:|.|::..       |           |:.|:  |:.|::.    |.|.
Zfish    38 HTERRGVIYSPLWPLNYPAGVNCS-------W-----------NIQGSRGDVITISF----HSFD 80

  Fly  1022 IV----IHNDWMYI-TDWRLDAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHEVQRIADTQPC 1081
            :.    ...||:.: ..|:.:     ::|.|.    ::..|..:....|.||.|.          
Zfish    81 LEETGDCRGDWLLLGPTWKAE-----YRLCGS----VLPPPFISSRGRVWVYFHS---------- 126

  Fly  1082 HRNNGGCQKICFAVPIGASNGTDGVTTSSPSFGRLQSRCSCPYGERLADDQVSCIPDPSAEPPVQ 1146
            |.|:.| |...|.:              |...|||              .|.||..|        
Zfish   127 HANSSG-QAQGFRM--------------SYIRGRL--------------GQSSCEKD-------- 154

  Fly  1147 PCPNSWDFTCNNQRCIPKSWLCDGDDDCLDNSDEEQNCTKP-------TCGSNEFQC---RSGRC 1201
                  ::.|.|.:|:|:||.|:|.|:|.||:| |:||..|       .|.....||   :|.||
Zfish   155 ------EYLCGNGKCVPRSWRCNGLDECGDNTD-ERNCVAPPTPARASLCPPGTLQCSDVQSTRC 212

  Fly  1202 IPQNFRCDQENDCGDNSDEQECGNVTCGT------SQFAC--------ANGRCIPNMWKCDSEN- 1251
            :|.:.||:...||.|.|||..|.:.:||.      ..||.        :.|..:...|..|::: 
Zfish   213 LPGSLRCNGARDCPDGSDEARCPDTSCGKRLVNFYGTFASPDFFRPNRSTGTDLHCTWFLDTKDP 277

  Fly  1252 -----------DCGDSSDEGDFCAEKT------------------------CAYFQFTCPRT--- 1278
                       ..|||....|...|:.                        .:.|....|.:   
Zfish   278 KPLVLQVDLQLGVGDSVRVYDGLGEQAERLLQSLSHHNNHRRALLESSQGQMSIFYHAKPHSPGH 342

  Fly  1279 ---------GHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCVEESYKCDGIPDC 1334
                     |:|.|....|..|:.|:                    :||:       :|||...|
Zfish   343 GFNATYQVKGYCFPGEHPCGTDEGCY--------------------SDLQ-------RCDGYWHC 380

  Fly  1335 NDGSDEVGCPSMGPNQCNLEKHFRCK-STGFCIPIAWHCDGSNDCSDHSDEQDCGQITCAQNFFK 1398
            ..|.||..||...|.:      :.|: .:|.|...:..|:....|.|.|||::|  ..|....|.
Zfish   381 PGGRDEEACPLCQPGE------YPCEGGSGACYSASERCNNQKKCPDGSDEKNC--FDCQPGNFH 437

  Fly  1399 CNNTNCVFKAYICDGKDDCGDNSDEGAEHACVP 1431
            |....|:|:.:.|||::||.|.|||....|.||
Zfish   438 CGTNLCIFETWRCDGQEDCMDGSDERDCLASVP 470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531 1/4 (25%)
LY 973..1007 CDD:214531 6/35 (17%)
Ldl_recept_a 1188..1223 CDD:278486 15/37 (41%)
LDLa 1227..1259 CDD:197566 10/57 (18%)
LDLa 1268..1303 CDD:238060 8/46 (17%)
LDLa 1308..1343 CDD:238060 9/34 (26%)
LDLa 1356..1387 CDD:238060 9/31 (29%)
LDLa 1391..1423 CDD:197566 12/31 (39%)
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
lrp3XP_009301583.1 CUB 31..141 CDD:238001 27/158 (17%)
LDLa 151..185 CDD:238060 16/48 (33%)
LDLa 197..234 CDD:238060 15/36 (42%)
CUB 239..350 CDD:238001 14/110 (13%)
LDLa 354..389 CDD:238060 14/61 (23%)
LDLa 392..428 CDD:238060 10/41 (24%)
LDLa 431..465 CDD:238060 14/33 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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