DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and egf

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_001106478.1 Gene:egf / 100127663 XenbaseID:XB-GENE-951823 Length:1051 Species:Xenopus tropicalis


Alignment Length:1372 Identity:287/1372 - (20%)
Similarity:438/1372 - (31%) Gaps:531/1372 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  2487 TSGGRNFRCECATGK---LSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNVV 2548
            |.|.:.:.|   ||.   |..:...|.....:|:|:...:|..:|.|.          |||..||
 Frog    20 TQGNKQWHC---TGNPLPLDNERYACNTPVPFLIFSHGNDIFTINSDG----------TNLRKVV 71

  Fly  2549 -------GLDFDFAHNRMLY-TQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKI 2605
                   .:||....||:.: .|.|.:.:..|...:|  |:.:..|   |....|.|.||....|
 Frog    72 PSAGSTLQIDFIQQENRLYWLDQNRGFLQRMYLNGSK--HERLRAV---GKGSIGFAIDWKHNVI 131

  Fly  2606 YWTDSSNNSI-YAMNLDGSELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSL 2669
            :|.:....:| .....:....|::..:..|:.:.:||..|.||   |....:...|.:.|:.||.
 Frog   132 FWANQQKGTIELTSRNEKRSRVLLRGLFNPKFVAIDPLEGLLF---WSSNKSWTIIQKATLDGSN 193

  Fly  2670 KRAIVDKDLSQP-SGLAIDYDERRLYWTDAVREKIERSD-------LDGQN----RELLVAATIY 2722
            ..:|:  :||.. .||.:|.|:::::|   :..||:|.|       .:|.:    :.|.::...:
 Frog   194 VTSII--ELSGALKGLTLDTDDKKIFW---ILSKIDREDSVIGSCSYNGDSVMIVKNLRLSTKYH 253

  Fly  2723 PFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVN---PCR 2784
            ...:::..|:||:::.:...:....|.||.::|.:  .|:.|..:||         |:.   |.|
 Frog   254 VLGVSLLYNHIYYSERKSGSIKVINKFTGKDIVSV--NLKPSIMEIR---------NIKVVYPVR 307

  Fly  2785 INNGGCAQSCHPAPNGKAECKCDDSTKVVNEGRMCAPRNNTCEASKFYCKNGRCISRMWSCDGDD 2849
                     .:..||..:           |:|.      .:|..|..:|..        :|:.| 
 Frog   308 ---------SYSIPNSSS-----------NQGA------KSCSISNKHCTK--------TCEID- 337

  Fly  2850 DCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCA 2914
                                    ..|.:|        |                 |::|....:
 Frog   338 ------------------------AENQKC--------H-----------------CMNGFVLSS 353

  Fly  2915 NGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCGDN 2979
            |||      .|..:|:|                                  ..|           
 Frog   354 NGR------YCEDINEC----------------------------------ALW----------- 367

  Fly  2980 SDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDN 3044
                                 ||.|                                  ...|:|
 Frog   368 ---------------------NHGC----------------------------------TLGCEN 377

  Fly  3045 GNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDC 3109
               ||..|.|                             ||.|                      
 Frog   378 ---IPGSYFC-----------------------------TCPE---------------------- 388

  Fly  3110 VDGADENTTLHNCATQQPCGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQE 3174
                                              |::...||                |||    
 Frog   389 ----------------------------------GYVLLPDN----------------KTC---- 399

  Fly  3175 FTCQNFKCIRNQSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADE 3239
                                    .|:..|..|:|                              
 Frog   400 ------------------------HDKTPCLTEHI------------------------------ 410

  Fly  3240 SDEPAHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLE-QPGACSQH 3303
                              :|.|.||.|..|..|.|.||..|..|||:|..   |.. ..|.||..
 Frog   411 ------------------ECSHGCVQTTKGPLCTCPEGSVLSEDGKSCTG---CTSPDNGGCSHI 454

  Fly  3304 C-SNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQY-NLMHQDLMN 3366
            | .:.||.:.|.|... |..|.|...|..... .|:|:|.|.:.:|.::.||..| :::...:..
 Frog   455 CIMSGPGTWECDCFPG-YNLQLDRKQCLASGP-RPYLMFANVHDIRRINFDGTNYESVLDSQIGR 517

  Fly  3367 VVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWL 3431
            |.|||:|..|:.|||.....|.|..|....:|      |:.:|..|...|||:.:|.:.|||||.
 Frog   518 VFALDYDPVEDRMYFAHTALKCIESANMDGSD------RKKMISGDLSTLEGLTVDAINRKLYWT 576

  Fly  3432 DRHSKNLDVSELDGSKRKTL-RSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRIL 3495
            ||....::.|:|:|..||.| :...:.||.|.|||....|::|.......|....::||....|:
 Frog   577 DRGKSCIERSDLNGKYRKILIQENNIQPRGICVHPLAKKLFWTHVGANPRIESSDLEGSEREVII 641

  Fly  3496 NWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSKVPHVFALSLFDDYIYW 3560
              :..:.||:.:::|:.||.|||.||....|..|:|:|.:|.: .|.:.|.|.||:|:|:|:::.
 Frog   642 --SKDLIWPSGITVDHLTDVIYWCDAKKSVIESANLDGSNRQS-FSQNDVGHPFAISVFEDHLWV 703

  Fly  3561 SDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQ------LPYTNPCGTNNGGCSHLCL 3619
            |||...:::|..|.:..|:..||....||..:.|.|||.:      :|.......:|...:|...
 Frog   704 SDWVQPSLIRIEKRNTQNWVRLRGNMQRPSSVVIVHPLAKPVIADDIPLPRKEKDSNNQTAHSES 768

  Fly  3620 IAPPPESTY----------------------------------LNIEGYIEEGAPIFKCACPNQF 3650
            ..|.|.||.                                  :|......|..|  ||.|...|
 Frog   769 FFPGPLSTSNAEMGTREAPSSRNGLLAEIMVSDDSGCIDIHCDINAHCVSSEDGP--KCQCLEGF 831

  Fly  3651 ----YLARDMKTC---VANCTAGQHLC----GGRDEKC----IPWFWKCDGEKDCKDGS---DEP 3697
                .|..|:..|   :|.|...|..|    ||...||    |....:|....:|..|:   .|.
 Frog   832 TGNGRLCHDIDECSLHIAACNPHQTECIDTEGGYICKCKYGYIGNGLQCTDIDECSRGTHTCGEN 896

  Fly  3698 ATCAPRHCRAGTFQCKNTNCTP-SATICDGVDDCGDRSDEQNCDLPCPLS-DFKCKSSGRCI--- 3757
            |.|....   |.:.|..||..| ||..|.|          :.....|||: |..|.:.|.||   
 Frog   897 AVCTNTE---GNYTCTCTNGFPGSAADCTG----------KTIIRECPLAYDGYCLNGGVCIHFP 948

  Fly  3758 -LDSWRC 3763
             |..:.|
 Frog   949 ELKDYGC 955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697 34/140 (24%)
NHL repeat 2593..2622 CDD:271320 7/29 (24%)
NHL repeat 2634..2678 CDD:271320 12/43 (28%)
LY 2671..2713 CDD:214531 13/53 (25%)
LDLa 2867..2901 CDD:238060 3/33 (9%)
LDLa 2906..2941 CDD:238060 8/34 (24%)
LDLa 2950..2983 CDD:238060 1/32 (3%)
LDLa 3034..3066 CDD:197566 6/31 (19%)
LDLa 3080..3115 CDD:197566 3/34 (9%)
LDLa 3128..3159 CDD:238060 3/30 (10%)
LDLa 3170..3204 CDD:238060 2/33 (6%)
LDLa 3210..3242 CDD:197566 0/31 (0%)
cEGF 3269..3292 CDD:289433 10/22 (45%)
vWFA <3284..3324 CDD:294047 13/41 (32%)
LY 3362..3394 CDD:214531 12/31 (39%)
LY 3406..3448 CDD:214531 16/41 (39%)
LY 3498..3536 CDD:214531 14/37 (38%)
LY 3536..3578 CDD:214531 14/41 (34%)
FXa_inhibition 3607..3659 CDD:291342 15/89 (17%)
LDLa 3663..3696 CDD:238060 11/43 (26%)
LDLa 3705..3739 CDD:238060 9/34 (26%)
LDLa 3743..3775 CDD:197566 10/26 (38%)
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
egfNP_001106478.1 LY 152..194 CDD:214531 12/44 (27%)
vWFA <346..398 CDD:320736 23/261 (9%)
FXa_inhibition 412..440 CDD:317114 14/27 (52%)
FXa_inhibition 447..480 CDD:317114 11/33 (33%)
LY 508..550 CDD:214531 13/47 (28%)
LY 554..593 CDD:214531 16/38 (42%)
Ldl_recept_b 615..654 CDD:278487 8/40 (20%)
LY 638..680 CDD:214531 15/43 (35%)
EGF_3 810..838 CDD:315598 7/29 (24%)
EGF_3 851..880 CDD:315598 8/28 (29%)
EGF_3 886..>914 CDD:315598 9/30 (30%)
PHA02887 <927..>967 CDD:333467 10/29 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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