DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pif1A and JAKMIP2

DIOPT Version :9

Sequence 1:	NP_001189195.2	Gene:	Pif1A / 8674049	FlyBaseID:	FBgn0261015	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_001257870.1	Gene:	JAKMIP2 / 9832	HGNCID:	29067	Length:	820	Species:	Homo sapiens

Alignment Length:	981	Identity:	207/981 - (21%)
Similarity:	360/981 - (36%)	Gaps:	315/981 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 KNKLKRKKKLSSSLTSVGDTVNQEKRTRIEGIQLHCRGKLRPKETQSFEAEKGPSAGSQKQLGKA 124
            :||.::.:.|..:|    ...|::.||::..||:....:  ..:....|.||...|...::|
Human     6 RNKGEKPEALIVAL----QAANEDLRTKLTDIQIELHQE--KSKVSKLEREKTQEAKRIREL--- 61

  Fly   125 EKDRERPVIIGGVTTTNVIAAPPQRIKRKLQENMDTIQKLNALTEQLRLEVNELKSSLITERGAV 189
             :.|:..|::             ..:|.||.|  :.:::|.|:.|.| ::.:|.:.|
Human    62 -EQRKHTVLV-------------TELKAKLHE--EKMKELQAVRENL-IKQHEQEMS-------- 101

  Fly   190 RALRAQNDADSRRWKSEVKKLQHTLEMAKKSNGIKKA--IESGPESSGAHVTADGLINYEIQRLT 252
            |.::.: |.:.:|.||.:..|:.     ..|:.::.|  ||:..|       |..|.:.|..:|.
Human   102 RTVKVR-DGEIQRLKSALCALRD-----GSSDKVRTALTIEAREE-------ARKLFDTERLKLL 153

  Fly   253 NEIAVLKEANRNKEEKTQIMGQADRLKAADMRQLKNAYENRLTHIQKSAKIEITRLLEEIKTKER 317
            .|||.||.|.:..:|....|.|||::||.|:|....:::..::.|:..::.:|.||::|||.|:|
Human   154 QEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDR 218

  Fly   318 NIGQLRKDL---------LALQ-------------------SPKK-----------------LKQ 337
            .|..|.|:|         |.||                   |||:                 |::
Human   219 IIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRR 283

  Fly   338 NE---AKVPATTKPKTNPNETSQKPKKPTTKAAGETKAKTEPDTDTDISEQNPIRQAQVTPEITQ 399
            |:   |::.||.:...:.|......:....|...||:.:.:|     :.|:|.....:....:..
Human   284 NQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKP-----LLERNKCLAKRNDELMVS 343

  Fly   400 LKNIELINNTKNAHKSALEMRTTMKSSQP-------NGLDDAPTRMRAP-------------DEM 444
            |:.:|  ...|...|...|||..:.|..|       |.||.|.......             ||:
Human   344 LQRME--EKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDEL 406

  Fly   445 RATTWMTTLVGSNCHSHSHS-------HPAVAKSKDPNSDTDSALSSAPPSISPQPPSSGSDSGV 502
              |.....|:....|..|..       .|.:...:|......|:::|.....:|..|....|..:
Human   407 --TRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESL 469

  Fly   503 I--------------WQTLQDLDKLQKE-------AEMYQKENERLQTEVQLMK---QELDA--A 541
            .              :|.||....|.:|       ||...|..|:||.||...|   ::|:|  |
Human   470 AAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLA 534

  Fly   542 EKAAISRAKKQAQI-----GELMQRIKELEEMQSSLEDEASELREQNELLEFRILELEDD----- 596
            :|...|...:..|:     .||:::|::.|.....|:.|..:.|:||||||||.||||:.
Human   535 QKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSP 599

  Fly   597 ---------SDKMESTCEGHC--QSLQDLLEQSAQRLEDRDKRCLQQLLQCVQQLDLDTMMPGDQ 650
                     ||.: |..:.:|  :.::|:                 .:...::|||:    .||.
Human   600 PFNLQIHPFSDGV-SALQIYCMKEGVKDV-----------------NIPDLIKQLDI----LGDN 642

  Fly   651 NRTETPKRHNSTHSHSHSHSHSQSHNHRIVATVQPYSNCATPTAPPTPSKRHCNQVSSWQSSSLS 715
            .                                               :.|:..||:..|:|::
Human   643 G-----------------------------------------------NLRNEEQVAIIQASTV- 659

  Fly   716 ESGVFVECDLLSNPNPIGHPHLQFYQERLEQLEGKLLIYESSGETQARHLAQRLQRELQLEKDLK 780
                                 |...::.::|:|         |...|.|     |:.::||.|::
Human   660 ---------------------LSLAEKWIQQIE---------GAEAALH-----QKMMELESDME 689

  Fly   781 ELADRVELLIEQNAQLEEAKCEFEEAENDTRLHLQRNEVELEILRQRNVELEFGKEALGAKYQ-D 844
            :..       :....|||.....::|.:...:.:|..|..|....|:...::|| |.|..|.| :
Human   690 QFC-------KIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFG-ELLSEKQQEE 746

  Fly   845 CRAEVLILRE---------DLAAAETQLEHLQAERKQAR----------KELQDLRRSLPLLLIF 890
            .|..|..||.         |....:.::|.||...::.|          ::::||...  .|.:|
Human   747 LRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEK--FLFLF 809

  Fly   891 RLLSLA 896
            ...|||
Human   810 LFFSLA 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pif1A	NP_001189195.2	JAKMIP_CC3	<156..282	CDD:292653	35/127 (28%)
Pif1A	NP_001189195.2	JAKMIP_CC3	<516..595	CDD:292653	34/95 (36%)
JAKMIP2	NP_001257870.1	Smc	24..804	CDD:224117	197/944 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..280		2/18 (11%)
		JAKMIP_CC3	410..602	CDD:406442	49/191 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..465		5/27 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002005
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000