DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pif1A and Jakmip2

DIOPT Version :9

Sequence 1:	NP_001189195.2	Gene:	Pif1A / 8674049	FlyBaseID:	FBgn0261015	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	XP_006526400.1	Gene:	Jakmip2 / 76217	MGIID:	1923467	Length:	831	Species:	Mus musculus

Alignment Length:	995	Identity:	198/995 - (19%)
Similarity:	361/995 - (36%)	Gaps:	314/995 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 KNKLKRKKKLSSSLTSVGDTVNQEKRTRIEGIQLHCRGKLRPKETQSFEAEKGPSAGSQKQLGKA 124
            :||.::.:.|..:|    ...|::.||::..||:....:  ..:....|.||...|...::|
Mouse     6 RNKGEKPEALIVAL----QAANEDLRTKLTDIQIELHQE--KSKVSKLEREKTQEAKRIREL--- 61

  Fly   125 EKDRERPVIIGGVTTTNVIAAPPQRIKRKLQENMDTIQKLNALTEQL-RLEVNELKSSLITERGA 188
             :.|:..|::             ..:|.||.|  :.:::|.|:.|.| :....|:..::....|.
Mouse    62 -EQRKHTVLV-------------TELKAKLHE--EKMKELQAVRENLIKQHEQEMSRTVKVRDGE 110

  Fly   189 VR----ALRAQNDADSRRWKSEVKKLQHTLEMAKKSNGIKKAIESGPESSGAHVTADGLINYEIQ 249
            ::    ||.|..|..|.:.::.:     |:|..:::   :|..::                 |..
Mouse   111 IQRLKSALCALRDGSSDKVRTAL-----TIEAREEA---RKQFDA-----------------ERL 150

  Fly   250 RLTNEIAVLKEANRNKEEKTQIMGQADRLKAADMRQLKNAYENRLTHIQKSAKIEITRLLEEIKT 314
            :|..||..||.|.:..:|....|.|||::||.|:|....:::..::.|:..::.:|.||::|||.
Mouse   151 KLLQEITDLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKA 215

  Fly   315 KERNIGQLRKDL---------LALQ-------------------SPKK----------------- 334
            |:|.|..|.|:|         |.||                   |||:
Mouse   216 KDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPD 280

  Fly   335 LKQNE---AKVPATTKPKTNPNETSQKPKKPTTKAAGETKAKTEPDTDTDISEQNPIRQAQVTPE 396
            |::|:   |::.||.:...:.|......:....|...||:.:.:|     :.|:|.....:....
Mouse   281 LRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKP-----LLERNKCLAKRNDEL 340

  Fly   397 ITQLKNIELINNTKNAHKSALEMRTTMKSSQP-------NGLDDAPTRMRAP------------- 441
            :..|:.:|  ...|...|...|||..:.|..|       |.||.|.......
Mouse   341 MVSLQRME--EKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNII 403

  Fly   442 DEMRATTWMTTLVGSNCHSHSHS-------HPAVAKSKDPNSDTDSALSSAPPSISPQPPSSGSD 499
            ||:  |.....|:....|..|..       .|.:...:|......|:::|.....:|..|....|
Mouse   404 DEL--TRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTDRTPATPDDDLD 466

  Fly   500 SGVI--------------WQTLQDLDKLQKE-------AEMYQKENERLQTEVQLMK---QELDA 540
            ..:.              :|.||....|.:|       ||...|..|:||.||...:   ::|:|
Mouse   467 ESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEA 531

  Fly   541 --AEKAAISRAKKQAQI-----GELMQRIKELEEMQSSLEDEASELREQNELLEFRILELEDD-- 596
              |:|...|...:..|:     .||:::|::.|.....|:.|..:.|:||||||||.||||:.
Mouse   532 TLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERER 596

  Fly   597 ------------SDKMESTCEGHC--QSLQDLLEQSAQRLEDRDKRCLQQLLQCVQQLDLDTMMP 647
                        ||.: |..:.:|  :.::|:                 .:...::|||:    .
Mouse   597 RSPPFNLQIHPFSDGV-SALQIYCMKEGVKDV-----------------NIPDLIKQLDI----L 639

  Fly   648 GDQNRTETPKRHNSTHSHSHSHSHSQSHNHRIVATVQPYSNCATPTAPPTPSKRHCNQVSSWQSS 712
            ||..                                               :.|:..||:..|:|
Mouse   640 GDNG-----------------------------------------------NLRNEEQVAIIQAS 657

  Fly   713 SLSESGVFVECDLLSNPNPIGHPHLQFYQERLEQLEGKLLIYESSGETQARHLAQRLQRELQLEK 777
            ::                      |...::.::|:|         |...|.|     |:.::||.
Mouse   658 TV----------------------LSLAEKWIQQIE---------GAEAALH-----QKMMELES 686

  Fly   778 DLKELADRVELLIEQNAQLEEAKCEFEEAENDTRLHLQRNEVELEILRQRNVELEFGKEALGAKY 842
            |:::..       :....|||.....::|.:...:.:|..|..|....|:...::||:.....:.
Mouse   687 DMEQFC-------KIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSDKQQ 744

  Fly   843 QDCRAEVLILRE---------DLAAAETQLEHLQAERKQARKELQDLRRSLPLLLIFRLLSLAKM 898
            ::.|..|..||.         |....:.::|.||    ||.:.::||.....:.. .::..|.:.
Mouse   745 EELRTAVEKLRRQMLRKSREYDCQILQERMELLQ----QAHQRIRDLEDKTDIQK-RQIKDLEEK 804

  Fly   899 GNEESSPGGSPRLSSGYTSS 918
            .|:|.  |..|:.::.:..|
Mouse   805 KNQEL--GSYPQKANAFKPS 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pif1A	NP_001189195.2	JAKMIP_CC3	<156..282	CDD:292653	29/130 (22%)
Pif1A	NP_001189195.2	JAKMIP_CC3	<516..595	CDD:292653	33/95 (35%)
Jakmip2	XP_006526400.1	Smc	24..804	CDD:224117	188/951 (20%)
Jakmip2	XP_006526400.1	JAKMIP_CC3	409..602	CDD:374316	48/192 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002005
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000