DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pif1A and Jakmip2

DIOPT Version :9

Sequence 1:	NP_001189195.2	Gene:	Pif1A / 8674049	FlyBaseID:	FBgn0261015	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_001100861.1	Gene:	Jakmip2 / 307479	RGDID:	1559742	Length:	857	Species:	Rattus norvegicus

Alignment Length:	996	Identity:	206/996 - (20%)
Similarity:	364/996 - (36%)	Gaps:	313/996 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 KNKLKRKKKLSSSLTSVGDTVNQEKRTRIEGIQLHCRGKLRPKETQSFEAEKGPSAGSQKQLGKA 124
            :||.::.:.|..:|    ...|::.||::..||:....:  ..:....|.||...|...::|
  Rat     6 RNKGEKPEALIVAL----QAANEDLRTKLTDIQIELHQE--KSKVSKLEREKTQEAKRIREL--- 61

  Fly   125 EKDRERPVIIGGVTTTNVIAAPPQRIKRKLQENMDTIQKLNALTEQL-RLEVNELKSSLITERGA 188
             :.|:..|::             ..:|.||.|  :.:::|.|:.|.| :....|:..::....|.
  Rat    62 -EQRKHTVLV-------------TELKAKLHE--EKMKELQAVRENLIKQHEQEMSRTVKVRDGE 110

  Fly   189 VR----ALRAQNDADSRRWKSEVKKLQHTLEMAKKSNGIKKAIESGPESSGAHVTADGLINYEIQ 249
            ::    ||.|..|..|.:.::.:     |:|..:::   :|..::                 |..
  Rat   111 IQRLKSALCALRDGSSDKVRTAL-----TIEAREEA---RKQFDA-----------------ERL 150

  Fly   250 RLTNEIAVLKEANRNKEEKTQIMGQADRLKAADMRQLKNAYENRLTHIQKSAKIEITRLLEEIKT 314
            :|..||..||.|.:..:|....|.|||::||.|:|....:::..::.|:..::.:|.||::|||.
  Rat   151 KLLQEITDLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKA 215

  Fly   315 KERNIGQLRKDL---------LALQ-------------------SPKK----------------- 334
            |:|.|..|.|:|         |.||                   |||:
  Rat   216 KDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPD 280

  Fly   335 LKQNE---AKVPATTKPKTNPNETSQKPKKPTTKAAGETKAKTEPDTDTDISEQNPIRQAQVTPE 396
            |::|:   |::.||.:...:.|......:....|...||:.:.:|     :.|:|.....:....
  Rat   281 LRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKP-----LLERNKCLAKRNDEL 340

  Fly   397 ITQLKNIELINNTKNAHKSALEMRTTMKSSQP-------NGLDDAPTRMRAP------------- 441
            :..|:.:|  ...|...|...|||..:.|..|       |.||.|.......
  Rat   341 MVSLQRME--EKLKAITKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNII 403

  Fly   442 DEMRATTWMTTLVGSNCHSHSHS-------HPAVAKSKDPNSDTDSALSSAPPSISPQPPSSGSD 499
            ||:  |.....|:....|..|..       .|.:...:|......|:::|.....:|..|....|
  Rat   404 DEL--TRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTDRTPATPDDDLD 466

  Fly   500 SGVI--------------WQTLQDLDKLQKE-------AEMYQKENERLQTEVQLMK---QELDA 540
            ..:.              :|.||....|.:|       ||...|..|:||.||...:   ::|:|
  Rat   467 ESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEA 531

  Fly   541 --AEKAAISRAKKQAQI-----GELMQRIKELEEMQSSLEDEASELREQNELLEFRILELEDD-- 596
              |:|...|...:..|:     .||:::|::.|.....|:.|..:.|:||||||||.||||:.
  Rat   532 TLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERER 596

  Fly   597 ------------SDKMESTCEGHC--QSLQDLLEQSAQRLEDRDKRCLQQLLQCVQQLDLDTMMP 647
                        ||.: |..:.:|  :.::|:                 .:...::|||:    .
  Rat   597 RSPPFNLQIHPFSDGV-SALQIYCMKEGVKDV-----------------NIPDLIKQLDI----L 639

  Fly   648 GDQNRTETPKRHNSTHSHSHSHSHSQSHNHRIVATVQPYSNCATPTAPPTPSKRHCNQVSSWQSS 712
            ||..                                               :.|:..||:..|:|
  Rat   640 GDNG-----------------------------------------------NLRNEEQVAIIQAS 657

  Fly   713 SLSESGVFVECDLLSNPNPIGHPHLQFYQERLEQLEG-------KLLIYESSGETQARHLAQRLQ 770
            ::                      |...::.::|:||       |::..||..| |...:...|:
  Rat   658 TV----------------------LSLAEKWIQQIEGAEAALHQKMMELESDME-QFCKIKGYLE 699

  Fly   771 RELQLEKDLKELADRVELLIEQ------NAQLEEAKCEFEEAENDTRLHLQRNEVELEILRQRNV 829
            .||...   |:..|:..:.|::      ||..:|...:|.|..:|.    |:.|:...:.:.|..
  Rat   700 EELDYR---KQALDQAYMRIQELEATLYNALQQETVIKFGELLSDK----QQEELRTAVEKLRRQ 757

  Fly   830 ELEFGKEALGAKYQDCRAEVLILRED---LAAAETQLEHLQAERKQARKELQDLRRSLPLL--LI 889
            .|...:|      .||:    ||:|.   |..|..::..|:.:....:::::||......|  .|
  Rat   758 MLRKSRE------YDCQ----ILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKTIQLSGAI 812

  Fly   890 FRLLSLAKMGNEESSPGGSPR 910
            |..|||..|.....|.|.|.:
  Rat   813 FFSLSLDLMIKSTGSAGRSQK 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pif1A	NP_001189195.2	JAKMIP_CC3	<156..282	CDD:292653	29/130 (22%)
Pif1A	NP_001189195.2	JAKMIP_CC3	<516..595	CDD:292653	33/95 (35%)
Jakmip2	NP_001100861.1	Smc	24..804	CDD:224117	191/943 (20%)
Jakmip2	NP_001100861.1	JAKMIP_CC3	410..602	CDD:292653	48/191 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002005
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000