Protein Alignment Pif1A and JAKMIP3

DIOPT Version :10

• Sequence 1: NP_001189195.2
• Gene: Pif1A / 8674049
• FlyBaseID: FBgn0261015
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: NP_001310015.1
• Gene: JAKMIP3 / 282973
• HGNCID: 23523
• Length: 990
• Species: Homo sapiens
• Alignment Length: 1026
• Identity: 210/1026 - (20%)
• Similarity: 377/1026 - (36%)
• Gaps: 344/1026 - (33%)

  Fly    58 MAKNKLKRKKK--LSSSLTSVGDTVNQEKRTRIEGIQLHCRGKLRPKETQSFEAEKGPSAGSQKQ 120
            |:|..:..:.|  .:.:|.:: ...|::.|.::..||:            ..:.||       .:
Human     1 MSKRGMSSRAKGDKAEALAAL-QAANEDLRAKLTDIQI------------ELQQEK-------SK 45

  Fly   121 LGKAEKDRERPVIIGGVTTTNVIAAPPQRIKRKLQENMDTIQKLNALTEQLRLEVNELKSSLITE 185
            :.|.|:::.:.:                   |:::|:..  .|...|..:|:.:::|.|   :.|
Human    46 VSKVEREKNQEL-------------------RQVREHEQ--HKTAVLLTELKTKLHEEK---MKE 86

  Fly   186 RGAVR-ALRAQNDADSRR----WKSEVKKLQHTLEMAKKSNGIKKAIESGPES------SGAHVT 239
            ..||| .|..|::|:..|    ..:|.::||..|...:         :.|||.      |.|...
Human    87 LQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALR---------DGGPEKVKTVLLSEAKEE 142

  Fly   240 ADGLINYEIQRLTNEIAVLKEANRNKEEKTQIMGQADRLKAADMRQLKNAYENRLTHIQKSAKIE 304
            |......|..::..||:.||.|.|..||...::.|||::|||::|.:.:.::..:|.|:|..:.|
Human   143 AKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE 207

  Fly   305 ITRLLEEIKTKERNIGQLRKDL--LALQSPKKLKQNEA---KVPATTKPKTNPNETSQKPKKPTT 364
            |.||:||||.|:|.:..|.::|  .|..:.:...|.||   ::....:...:|.    .|::...
Human   208 IRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPG----SPRRELP 268

  Fly   365 KAAGETKAKT---EPDTDTD----------ISEQNPI------RQAQVTPEITQL---------- 400
            .|||...|..   .|:...|          |:|.:.|      |.|.::.|..:|
Human   269 HAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQ 333

  Fly   401 -------------KNIELI-------NNTKNAHKSALEMR----TTMKSSQPNGLDDAPTRMRAP 441
                         ||.:|.       |..|...:..:|||    ...:.|..|.||.:.......
Human   334 YKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVD 398

  Fly   442 -------------DEMRATTWMTTLVGSNCHSHS-----HSHPAVAKSKDP-------NSDTDSA 481
                         ||:..|......|.|......     .....:||...|       ..|.:::
Human   399 FLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEAS 463

  Fly   482 LSSAPPSIS---------PQPPSSGSDSGVI--------------WQTLQDLDKLQKE------- 516
            |.|...|:|         |..|....:.|:.              :|.||....|.:|
Human   464 LESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLD 528

  Fly   517 AEMYQKENERLQTEVQLMKQELDAAEKAAISRA-------KKQA---QIGELMQRIKELEEMQSS 571
            ||...|..|:||.|||..:..::..|||...:.       :|||   :..||:::||::|..::.
Human   529 AEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEAR 593

  Fly   572 LEDEASELREQNELLEFRILELE-----------------DDSDKMESTCEGHCQSLQDLLEQSA 619
            |..|..:.|:|||||||||||||                 |....::..||  .:.:.|::
Human   594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCE--AEGVTDIV---- 652

  Fly   620 QRLEDRDKRCLQQLLQCVQQLDLDTMMPGDQNRTETPKRHNSTHSHSHSHSHSQSHNHRIVATVQ 684
                         :.:.:::||:    .||                   ::.|...|...|..:|
Human   653 -------------VAELMKKLDI----LGD-------------------NAVSNLTNEEQVVVIQ 681

  Fly   685 PYSNCATPTAPPTPSKRHCNQVSSWQSSSLSESGVFVEC--DLLSNPNPIGHPHLQFYQERLEQ- 746
            ..:..       |.:::...|:...: ::|....|.:|.  :|.|.........|.:.::.|:|
Human   682 ARTVL-------TLAEKWLQQIEETE-AALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQA 738

  Fly   747 ----LEGKLLIYESSGETQARHLAQRLQRELQLEKDLKELADRVELLIEQNAQLEEAKCEFEEAE 807
                ||.:.::|::..:.....:|:.|..|.:         :::::.:||    .:.:...|..|
Human   739 NKHILELEAMLYDALQQEAGAKVAELLSEEER---------EKLKVAVEQ----WKRQVMSELRE 790

  Fly   808 NDTRLHLQRNEVELEILRQRNVELEFGKEALGAKYQDCRAEVLILREDLAAAETQLEHLQAERKQ 872
            .|.::..:|.|: |::.:||..|||                               |.::|:::|
Human   791 RDAQILRERMEL-LQLAQQRIKELE-------------------------------ERIEAQKRQ 823

  Fly   873 ARKELQDLRRSLPLLLIFRLLSLAKMGNEESSPGGSPRLS-SGYTSSIHQD 922
            . |||::                              :|| ||::.|.|.|
Human   824 I-KELEE------------------------------KLSFSGHSPSWHPD 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pif1A	NP_001189195.2	JAKMIP_CC3	<516..595	CDD:464986	37/112 (33%)
		Smc	<741..>1156	CDD:440809	34/188 (18%)
JAKMIP3	NP_001310015.1	SMC_prok_B	27..831	CDD:274008	198/985 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..290		8/43 (19%)
		JAKMIP_CC3	429..625	CDD:464986	52/195 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..489		5/22 (23%)