Protein Alignment Pif1A and JAKMIP1

DIOPT Version :9

• Sequence 1: NP_001189195.2
• Gene: Pif1A / 8674049
• FlyBaseID: FBgn0261015
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: XP_016863277.1
• Gene: JAKMIP1 / 152789
• HGNCID: 26460
• Length: 843
• Species: Homo sapiens
• Alignment Length: 1141
• Identity: 238/1141 - (20%)
• Similarity: 421/1141 - (36%)
• Gaps: 358/1141 - (31%)

  Fly    74 TSVGDTVNQEKRTRIEGIQLHCRGKLRPKETQSFEAEKGPSAGSQKQLGKAEKDRERPVIIGGVT 138
            |......|:|.|.::..||:            .|:.||......:::|.:|:.:||
Human    16 TDAVQMANEELRAKLTSIQI------------EFQQEKSKVGKLRERLQEAKLERE--------- 59

  Fly   139 TTNVIAAPPQRIKRKLQENMDTIQKLNA-LTEQLRLEVNELKSSLIT--ERGAVRALRAQNDADS 200
                         ::.:.:...|.:|.| |.|:...|:..|:..||.  |:.|.|..:.:
Human    60 -------------QEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIK----- 106

  Fly   201 RRWKSEVKKLQHTLEMAK--KSNGIKKAI--ESGPESSGAHVTADGLINYEIQRLTNEIAVLKEA 261
               :.|:::||.||.:.:  .::.:|.|:  |:..|:..|.   ||    |..||..||..||.|
Human   107 ---EGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAF---DG----ERLRLQQEILELKAA 161

  Fly   262 NRNKEEKTQIMGQADRLKAADMRQLKNAYENRLTHIQKSAKIEITRLLEEIKTKERNIGQLRKDL 326
            .:..||......|||:.||||:|....|:::.:..|::..:.:|.||::|||.|:|.|..|.|:|
Human   162 RKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL 226

  Fly   327 --LALQSPKKLKQNEAKVPATTKPKTNPNETSQKPKKPTTKAAGETKAKTEPDTDTDISEQNPIR 389
              .|.|:.|.|.|.||                                         :.||
Human   227 GVQAGQTQKLLLQKEA-----------------------------------------LDEQ---- 246

  Fly   390 QAQVTPEITQLKNIELINNTKNAHKSALEMRTTMKSSQPNGLDDAPTRMRAPDEMRATTWMTTLV 454
                   :.|:|..|       .|.|      :.|...|.|:.|                |..|:
Human   247 -------LVQVKEAE-------RHHS------SPKRELPPGIGD----------------MVELM 275

  Fly   455 GSNCHSHSHSHPAVAKSKDPNSDTDSALSSAPPSISPQPPSSGSDSGVIWQTLQDLDKLQKEAEM 519
            |                                                   :||
Human   276 G---------------------------------------------------VQD---------- 279

  Fly   520 YQKENERLQTEVQLMKQELDAAEKAAISRAKKQAQIGELMQRIKELEEMQSSLEDEASELREQNE 584
             |..:||.....||                    :|.||...|::||:..:.|.||.:||.:::.
Human   280 -QHMDERDVRRFQL--------------------KIAELNSVIRKLEDRNTLLADERNELLKRSR 323

  Fly   585 LLEFRILELEDDSDKMESTCEGHCQSLQDLLEQSAQRLEDRDKRCLQQLLQCVQQLDLDTMMPGD 649
            ..|.::..|.:.:.:|....|       ||| ||.||:|::.|...::.::..::|.....:
Human   324 ETEVQLKPLVEKNKRMNKKNE-------DLL-QSIQRMEEKIKNLTRENVEMKEKLSAQASL--- 377

  Fly   650 QNRTETPKRHNSTHSHSHSHSHSQSHNHRIVATVQPY--SNCATPTAPPTPSKRHCNQVSSWQSS 712
                   |||.|.:..|.:....:....|:....|.:  .:.:........||||       :..
Human   378 -------KRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRH-------RGK 428

  Fly   713 SLSESGVFVECDLLSNPNPIGHPHLQFYQERLEQLEGKLLIYES--------SGETQARHLAQRL 769
            ||..              |..|....|:....|.::.:.|...|        :..|....|....
Human   429 SLKP--------------PKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479

  Fly   770 QRELQLEKDLK--ELADRVELLIEQNAQLEEAKCEFEEAENDTRLHLQRNEVELEILRQRNVELE 832
            .||   |.||:  :|....:.|....|.|:|......:||.:.|   .|.:::.::||.: .::|
Human   480 ARE---EADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR---TREQLQADLLRCQ-AKIE 537

  Fly   833 FGKEALGAKYQDCR---AEVLILREDLAAAETQLEHLQAERKQARKELQDLRRSLPLLLIFRLLS 894
            ..::.|..|.||.:   .:.|::|.:....| ::..|:.|..|.:.|:||.:.... ||.||:|.
Human   538 DLEKLLVEKGQDSKWVEEKQLLIRTNQDLLE-KIYRLEMEENQLKNEMQDAKDQNE-LLEFRVLE 600

  Fly   895 LAKMGNEESSPGGSPRLSS---GYTSSI----HQD--RDFSAKIQTTEFD-LGQAGFTDSGEERE 949
            |.:  .|..||..:.::::   .::|::    ||:  :|.:......:.| ||..|...:.|:..
Human   601 LEE--RERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVA 663

  Fly   950 IVYLKEEVKSLRSQLKELNARHYEAMETA-DSHWVDLEQQYKEREEAQQAKEASLKQKIAQLQDC 1013
            |:.....:......||::     |..|.| ....:|||   ||::...:.| ..|::::...:..
Human   664 IIQAGTVLALCEKWLKQI-----EGTEAALTQKMLDLE---KEKDLFSRQK-GYLEEELDYRKQA 719

  Fly  1014 LREDSRAATEKIQQLEEGELSLKSCLVRMTKEHRDLLTENRTLQCSLESLMAKMEKEAEHKMPLT 1078
            |.:......||||.||                        .||..:|:....:...||
Human   720 LDQAYLVGPEKIQDLE------------------------ATLYTALQQEPGRRAGEA------- 753

  Fly  1079 EALENERRKTQALMDDLIFAKKVQQNTEDQLRQETDALRTQIFNIKKDYLHIEVTNGELKEEVGT 1143
             ..|.:|...||.::      ||::    |:.:::....:||...:.:.|.      :.::.:..
Human   754 -LSEGQREDLQAAVE------KVRR----QILRQSREFDSQILRERMELLQ------QAQQRIRE 801

  Fly  1144 LENKIRQMENQMRDSEER-ARC-LED--ELRTKDEQ 1175
            ||:|:...:..:::.||: :.| |:|  |.||:|.:
Human   802 LEDKLEFQKRHLKELEEKHSFCGLDDFSEPRTRDRK 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pif1A	NP_001189195.2	JAKMIP_CC3	<156..282	CDD:292653	39/132 (30%)
		JAKMIP_CC3	<516..595	CDD:292653	18/78 (23%)
JAKMIP1	XP_016863277.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002005
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000