DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr21 and SDK1

DIOPT Version :9

Sequence 1:NP_001163838.2 Gene:dpr21 / 8674044 FlyBaseID:FBgn0260995 Length:282 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:242 Identity:62/242 - (25%)
Similarity:99/242 - (40%) Gaps:39/242 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 TDLYLISENIVPMKRVLDRGPYFDTSATKNVTSLVGITGHLNCRIKNLGNKTVSWIRHRDLHLLT 95
            |..||...||.|   |..:.| .||:.|.      |:|..|.|.:.......::|  .|:.|:|.
Human   469 THTYLDVTNIAP---VFTQRP-VDTTVTD------GMTAILRCEVSGAPKPAITW--KRENHILA 521

  Fly    96 VSESTYTSDQRFTSIYNKQTGDWSLQIKFPQLRDSGIYECQVSTTPPVGYTMVFSVVEPITSILG 160
                  :...|.......::|  .|||....::|:|.|.|..:.|...........|...|||:.
Human   522 ------SGSVRIPRFMLLESG--GLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVH 578

  Fly   161 GPEIYIDL-GSTVNLTCVIKHLPDPPISVQ--WNHNNQEINYDSPRGGVSVITEKGDITTSYLLI 222
            .||.::.: |:|..|.|...|  ||.:|::  |..:|..:   :|.....::.||    ...|||
Human   579 PPEDHVVIKGTTATLHCGATH--DPRVSLRYVWKKDNVAL---TPSSTSRIVVEK----DGSLLI 634

  Fly   223 QRASIADSGQYTC--LPSNAN-SKSVNVHILKGDHPAAVQKSHLLVS 266
            .:....|.|.|:|  :....| |:...:.:::..|    ...:||||
Human   635 SQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPH----SPQNLLVS 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr21NP_001163838.2 Ig 71..149 CDD:299845 16/77 (21%)
IG_like 71..140 CDD:214653 15/68 (22%)
IG_like 162..249 CDD:214653 24/92 (26%)
IGc2 169..242 CDD:197706 21/77 (27%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706
I-set 386..475 CDD:254352 3/5 (60%)
Ig 404..472 CDD:143165 1/2 (50%)
I-set 480..570 CDD:254352 24/109 (22%)
Ig 494..570 CDD:299845 18/85 (21%)
I-set 575..664 CDD:254352 26/97 (27%)
Ig 580..664 CDD:299845 24/92 (26%)
FN3 668..759 CDD:238020 5/14 (36%)
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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