DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and CYR1

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	1368	Identity:	245/1368 - (17%)
Similarity:	452/1368 - (33%)	Gaps:	476/1368 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VYLDLRWNDTKGDTVL---ATKAITEMICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKCAEYR 128
            |::|||..|.....::   .|..|..:.....|.||.|     :|.|.|   :|.::|.:....|
Yeast   795 VHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLP-----LEFIES---SIKLLSLRMVNIR 851

  Fly   129 ASAIPT----------------FARTEPPDTQVVKSLLAL---------------------LRYY 156
            ||..|:                |.|..|.....:.:|..|                     |...
Yeast   852 ASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLLDL 916

  Fly   157 AWNKFSILYEDVWSPVADLLK-----------DQATK-----RNMTINH-KQSFI---------- 194
            :.||| :.|.:|.:...:||:           .|:||     ..|.::| |.:||
Yeast   917 SSNKF-MHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGDLSEMTDLR 980

  Fly   195 -------------------------DNRVKCCEQMLDCCRS---------------GYWYQLVQN 219
                                     |||:...|..|...|:               .|...:...
Yeast   981 TLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENPITSISFKDFYPKNMTSL 1045

  Fly   220 TMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSN 284
            |:|:.::....|...:.:.|:..:|                   .::....:..:.:.::|.:.
Yeast  1046 TLNKAQLSSIPGELLTKLSFLEKLE-------------------LNQNNLTRLPQEISKLTKLV- 1090

  Fly   285 CHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSK-PPF-----NLEIPRLFVESNFSKFI 343
                  |..:||:.|  ...||....::..:.:..:|:. ..|     |||:..|.:.||.....
Yeast  1091 ------FLSVARNKL--EYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNS 1147

  Fly   344 SI---------YAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEV-------------ASNGTR 386
            |:         |.:.|..|:..:. |.|...        ||.::.:             .:|.:.
Yeast  1148 SLENSFYHNMSYGSKLSKSLMFFI-AADNQF--------DDAMWPLFNCFVNLKVLNLSYNNFSD 1203

  Fly   387 VIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWN-------NSNNM---PCNY-HMV 440
            |....:::.|.:.::|:|: ....||     :||     ||:       |||.|   |... ::.
Yeast  1204 VSHMKLESITELYLSGNKL-TTLSGD-----TVL-----KWSSLKTLMLNSNQMLSLPAELSNLS 1257

  Fly   441 PVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFC 505
            .::.|..|....:|.:.|...||.....|                 :..|
Yeast  1258 QLSVFDVGANQLKYNISNYHYDWNWRNNK-----------------ELKY--------------- 1290

  Fly   506 SGVITMSIYRKWKI-------------------ELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVS 551
               :..|..|:::|                   :|::.||: .:..|..|....|......:..|
Yeast  1291 ---LNFSGNRRFEIKSFISHDIDADLSDLTVLPQLKVLGLM-DVTLNTTKVPDENVNFRLRTTAS 1351

  Fly   552 LMSAQSYGSRWT---NQFVTSTG----RLRG----AVVRIKELKFPRKRDISREIMKEMR----- 600
            :::...||...|   ..:|:|..    |.||    .::.:.:.| .:..|....|.:.:|
Yeast  1352 IINGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSK-NQNADYGHNISRIVRDIYDK 1415

  Fly   601 -LLRELRH------DNIN-----SFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIAS 653
             |:|:|..      |||.     ||:..:.|           ..|.|..:....|:.  :|..|.
Yeast  1416 ILIRQLERYGDETDDNIKTALRFSFLQLNKE-----------INGMLNSVDNGADVA--NLSYAD 1467

  Fly   654 LIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQL 718
            |:......:|||...:| :..||.....::                     :::.|::|
Yeast  1468 LLSGACSTVIYIRGKKL-FAANLGDCMAIL---------------------SKNNGDYQ------ 1504

  Fly   719 WRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQIN-------FEPKEIVDYVKKLPLKGE 776
                .|.:.|:...::         .||.....|  |.:|       .:....|.:...||   .
Yeast  1505 ----TLTKQHLPTKRE---------EYERIRISG--GYVNNGKLDGVVDVSRAVGFFDLLP---H 1551

  Fly   777 DPFRPEVESIIEAESCPDYVLACIRDCW-----------AEDPEERPEFSVIRNRLKKMRGGKTK 830
            ....|:: |::......:.::......|           |.:....|..:....:...|..|.|:
Yeast  1552 IHASPDI-SVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTE 1615

  Fly   831 NI------MDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTED-LLHRMLPQSVAEKLTMGQGVE 888
            ||      :.:.::...::..|...::|.|:..        || .|.|:.|:           :.
Yeast  1616 NITILCLALYENIQQQNRFTLNKNSLMTRRSTF--------EDTTLRRLQPE-----------IS 1661

  Fly   889 PVSYDLVTIYFSDIVGFTAM-----SAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYM 948
            |.:.:|..: |:||...|.:     :|..|.::..|      .:..|.:|.|..|:|:|.|||:|
Yeast  1662 PPTGNLAMV-FTDIKSSTFLWELFPNAMRTAIKTHN------DIMRRQLRIYGGYEVKTEGDAFM 1719

  Fly   949 V-----VSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPN-------------ETLKLRIGM 995
            |     .|||.         ...|:.|:||.|.....|....:             :.|.:|:|:
Yeast  1720 VAFPTPTSGLT---------WCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGI 1775

  Fly   996 HTG-PVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGY---ITEKR 1056
            |.| ||..  :.|...|....|..||.|:|::...:..:|.:|:......:|:...:   :..|.
Yeast  1776 HWGCPVPE--LDLVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKE 1838

  Fly  1057 GLVNMKGK---GDV----------VTWWLTGANENAIQ----KKLVDMMDMPPPLFSRPR----- 1099
            .|..:.|:   |:|          :.|......|:.::    |:||.:. .|..|.||..
Yeast  1839 SLKEVYGEEIIGEVLEREIAMLESIGWAFFDFGEHKLKGLETKELVTIA-YPKILASRHEFASED 1902

  Fly  1100 KSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDG---ESTYSLQGS-VRESPRM-------VS 1153
            :..||..::....::.:      |.|..::..|:.|   |.....:|| ::.:|::       :|
Yeast  1903 EQSKLINETMLFRLRVI------SNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENGIMQSIS 1961

  Fly  1154 KRD 1156
            ::|
Yeast  1962 EKD 1964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	92/523 (18%)
		ANF_receptor	48..412	CDD:279440	81/479 (17%)
		PK_GC-A_B	543..827	CDD:270944	52/329 (16%)
		HNOBA	<835..881	CDD:285003	8/46 (17%)
		CYCc	860..1052	CDD:214485	51/219 (23%)
		Guanylate_cyc	887..1074	CDD:278633	52/226 (23%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	95/534 (18%)
		leucine-rich repeat	796..817	CDD:275380	5/20 (25%)
		leucine-rich repeat	818..839	CDD:275380	8/28 (29%)
		leucine-rich repeat	840..864	CDD:275380	6/23 (26%)
		leucine-rich repeat	865..887	CDD:275380	3/21 (14%)
		leucine-rich repeat	888..910	CDD:275380	2/21 (10%)
		leucine-rich repeat	911..933	CDD:275380	6/22 (27%)
		leucine-rich repeat	934..956	CDD:275380	5/21 (24%)
		leucine-rich repeat	957..978	CDD:275380	5/20 (25%)
		leucine-rich repeat	979..1018	CDD:275380	5/38 (13%)
		leucine-rich repeat	1019..1041	CDD:275380	2/21 (10%)
		leucine-rich repeat	1042..1065	CDD:275380	3/22 (14%)
		leucine-rich repeat	1066..1088	CDD:275380	1/40 (3%)
		leucine-rich repeat	1089..1111	CDD:275380	6/30 (20%)
		leucine-rich repeat	1167..1187	CDD:275380	4/28 (14%)
		leucine-rich repeat	1191..1211	CDD:275380	2/19 (11%)
		leucine-rich repeat	1236..1258	CDD:275380	5/21 (24%)
		leucine-rich repeat	1259..1287	CDD:275380	7/44 (16%)
		PP2C	1374..1617	CDD:395385	48/303 (16%)
		CYCc	1613..1825	CDD:214485	56/248 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900