DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and si:dkey-37g12.1

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_021333677.1	Gene:	si:dkey-37g12.1 / 796669	ZFINID:	ZDB-GENE-090312-145	Length:	882	Species:	Danio rerio

Alignment Length:	942	Identity:	358/942 - (38%)
Similarity:	505/942 - (53%)	Gaps:	125/942 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 WSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAA 233
            |.|||...  ||...|:|:...|..        ...|....:..|.:::.......||.|.....
Zfish    27 WLPVAQTY--QAEHNNITVAKYQDI--------HSSLSQGSTSNWSRVLNEMAQVARIIVISAHG 81

  Fly   234 NSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMS-NCHSTENFNQMARS 297
            ..:...:......|| ..|::  :|.....|.::           :.|.| :....::::.||:.
Zfish    82 KVVRSLLIEAHKKGL-TNGDF--VFFCFEPYKQK-----------VLFGSFDWEQGDSYDSMAKQ 132

  Fly   298 -----LLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNF----SKFISIYAAYLYDS 353
                 ..:....|..|.|..|::.|            |.|..::..:    ::.:|:.||..:|:
Zfish   133 AYQALFFLSLYKPSDKRYQAFSENV------------ISRSKIDFGYTYAQTEKVSVLAAIAHDT 185

  Fly   354 VKLYAWAVDKMLREETRVLTDDVIFEVASNGT----RVIDTIIKNRTYMSITGSKIKIDQYGDSE 414
            |.|||.|:::.|               |.||.    ..:...:.|||...|.|. :.||..||.|
Zfish   186 VWLYAHALNETL---------------AENGNPYDGLAVTRRMWNRTIKGIQGD-VTIDASGDRE 234

  Fly   415 GNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLING-SIDWPSG-GEKPADEPMCG 477
                 |.|...:...|||. |   .|...||      ..||.:.| .|.||.| ...|.|.|.||
Zfish   235 -----LNYMMKQIRGSNNQ-C---QVVANYF------GTYKAVKGVQILWPGGLTSPPKDSPDCG 284

  Fly   478 FANELCKKDDTHYTSTVAAVVLGVL--LFCSGVITMSI-YRKWKIELEIEGLLWKIDPNEI---- 535
            |..|||...:..:     .:.||::  |..:|.:.:.: |||:|:..|...:||.|:.|::
Zfish   285 FRGELCINLERKF-----LIALGIIAGLMAAGTLAICVLYRKYKLPEEASKMLWTINANDVIMME 344

  Fly   536 --------KGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDIS 592
                    |.:....:.:|...: :.|.|...|      ...|...:|.:..:..:.. |...::
Zfish   345 HHSSTVPEKSHRSKPLQASLESI-ICSMQDKPS------AHRTAVYKGTICSVSFVNL-RSTHLN 401

  Fly   593 REIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHD 657
            .|::.|::..|:|.|.|:..||||::|.::..::|:||.||||.||::||.||||..|..||:.|
Zfish   402 SELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLD 466

  Fly   658 LIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAP 722
            ::|||.|:|:|.|.|||:|.||:|||.||::|:||||||:.:|:....:|.|. ..:...|||||
Zfish   467 IVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVRRLDTEQSPGS-DPWTALLWRAP 530

  Fly   723 ELLRNHI--HGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGEDPFRPEV 783
            ||||..|  :|:||||||:||||..|:..|:|||  ...:|.|:|||:.|:   ..|..|.||
Zfish   531 ELLRQSIPANGTQKGDVYSFAIIAQEVVYRRGPFYIPNSHFSPREIVERVR---AGGCSPSRP-- 590

  Fly   784 ESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKK-MRGGKTKNIMDQMMEMMEKYANNL 847
              .|:...|.:.:.:.:..||.|.|.|||:||.||..:|| ...|.::||:|.::..||:||.||
Zfish   591 --YIDRAECVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNL 653

  Fly   848 EDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAES 912
            |:||:|||..|.|||.:.|.||.:|||:|||.:|..|:.|...:||.||||||||.|||||||..
Zfish   654 EEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASL 718

  Fly   913 TPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVK 977
            ||:||||.||||||.||.||..::|||||||||||||||||||:|||.||.|||.|:|.::..::
Zfish   719 TPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLR 783

  Fly   978 QHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKL 1042
            .....|.|.:.|::|||:|:||.|||||||.|||||||||||||||||||.|..||||:|:..|.
Zfish   784 SFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKS 848

  Fly  1043 ALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            .||.. ..:..|.||.:::||||.|.|:||.|
Zfish   849 LLDTF-RNFRCELRGDIHIKGKGWVRTFWLLG 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	60/289 (21%)
		ANF_receptor	48..412	CDD:279440	50/256 (20%)
		PK_GC-A_B	543..827	CDD:270944	116/288 (40%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	121/191 (63%)
		Guanylate_cyc	887..1074	CDD:278633	118/186 (63%)
si:dkey-37g12.1	XP_021333677.1	Periplasmic_Binding_Protein_Type_1	<59..258	CDD:324556	52/255 (20%)
		PKc_like	355..628	CDD:328722	114/288 (40%)
		HNOBA	<641..687	CDD:311573	25/45 (56%)
		CYCc	666..850	CDD:214485	119/183 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810