DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	122/351 - (34%)
Similarity:	179/351 - (50%)	Gaps:	65/351 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   743 IMYEIFSRKGPFGQINFEPKEIVDYV-----KKL------PLKGEDPFR---PEV----ESIIEA 789
            |....|.|..|| .:.|:|..:|..:     |:|      .||.||.|.   |:|    :.::..
  Rat   316 ISINTFCRTFPF-HLMFDPNMVVLQLGEGLRKQLRCDNHKVLKFEDCFEIVSPKVNATFDRVLLR 379

  Fly   790 ESCPDYVLACIRDCWAEDPEER-----------PEFSVIR-------NRLKKMRG---------- 826
            .|.| :|:....:....|.|::           ||.:.|.       ::|.::.|
  Rat   380 LSTP-FVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPI 443

  Fly   827 ----------GKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKL 881
                      |:.....|.:.:.|:|....||    :..:.|.|||.||.|||:.:.|..||::|
  Rat   444 HDATRDVILVGEQAKAQDGLKKRMDKLKATLE----KTHQALEEEKKKTVDLLYSIFPGDVAQQL 504

  Fly   882 TMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDA 946
            ...|.|:...:|.||:.|||||||||:.|:.||:||::.||:|||.||......|:|||||||||
  Rat   505 WQRQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDA 569

  Fly   947 YMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPR 1011
            |.|.|||..|: ..||..||.|||:::...::  :.......:::|||:|:|.|:|||||:.|||
  Rat   570 YCVASGLHRKS-LCHAKPIALMALKMMELSEE--VLTPDGRPIQMRIGIHSGSVLAGVVGVRMPR 631

  Fly  1012 YCLFGDTVNTASRMESNGEALKIHIS 1037
            |||||:.|..||:.||.....:|:||
  Rat   632 YCLFGNNVTLASKFESGSHPRRINIS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	27/139 (19%)
		HNOBA	<835..881	CDD:285003	16/45 (36%)
		CYCc	860..1052	CDD:214485	88/178 (49%)
		Guanylate_cyc	887..1074	CDD:278633	75/151 (50%)
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	43/190 (23%)
		CYCc	483..672	CDD:214485	88/178 (49%)
		Guanylate_cyc	512..696	CDD:278633	74/149 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810