DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and gucy2cb

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_021329920.1	Gene:	gucy2cb / 568219	ZFINID:	ZDB-GENE-130531-31	Length:	1071	Species:	Danio rerio

Alignment Length:	1030	Identity:	291/1030 - (28%)
Similarity:	466/1030 - (45%)	Gaps:	220/1030 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 DCCRSGYWY------------------QLVQNTMNRTR----------IYVFLGAANSLVDFMSS 242
            ||    :||                  ::::|..:.|:          :::..|..:.::|..:.
Zfish   196 DC----FWYINALEVSNGGFSPSLQEIEVIRNKEDLTKAMAKHNRESNLFILCGTPDDIMDLKNG 256

  Fly   243 METAGLFARGEYMVIFVDMM--VYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTP 305
            .....    .|...:.:|:.  :|.:.::..::|.|                       :|.:.|
Zfish   257 TTDYD----SEIAFLLIDLYNDIYYKGQSNTFMRNV-----------------------LVLTMP 294

  Fly   306 PTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETR 370
            .|:.|.                       ::::.:..::.|.|..:|:|.|:...:..:.:..:.
Zfish   295 NTRKYT-----------------------IDTSGNNTMNDYIAAYHDAVLLFGQVMRNIQKSGSL 336

  Fly   371 VLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPC 435
            .:.|  :..|:.|       ..:|.::..|.| :.::||:||.:..||::      :.|:||
Zfish   337 DIQD--MESVSMN-------YFRNVSFTGIAG-EYQLDQHGDRDLMFSLI------YTNNNN--- 382

  Fly   436 NYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLG 500
            .|::  :..|:........|..:.|..|.|  ..|.|.|..|.:           ...:..:||.
Zfish   383 QYNI--LYQFNTSNNKTGLKDSSPSFIWQS--RLPNDSPSKGLS-----------VIEIIVIVLC 432

  Fly   501 VLLFCSGVITMSIY----------RKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSA 555
            .::...|.:....|          ::|.   .|...|  |.|.|:..:         :.:||...
Zfish   433 TVIGIMGTLAFIFYWQNRYYHHMQKRWS---HISSQL--ITPLELNEW---------NMISLKIE 483

  Fly   556 QSYGSRWTNQFVTSTGRLRGAVVRIKELK-----FPRKRDISREIMKEMRLLRELRHDNINSFIG 615
            :.  |...:.::....|....:|.:||.:     |..|:.|      |:..|.::.:.|:..|.|
Zfish   484 ED--STENSTYILRRARYDKKIVILKEFRLTDGSFTEKQRI------ELNTLLKIDYCNLTKFYG 540

  Fly   616 ASVEPTRILLVTDYCAKGSLYDIIEN-----EDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGN 675
            ..........|.:|..:|||..::::     |:..:|..|..|:::|:.|||.|:|.|.:..||.
Zfish   541 TVKFDNEYFGVFEYGERGSLRYVLDDKISYPEETFMDWQFKISVMYDIAKGMSYLHTSNIAVHGR 605

  Fly   676 LKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHG-SQKGDVYA 739
            |||:||||.:|.::::.|||.:.:...:|:            ||.|||.||.  .| |||||||:
Zfish   606 LKSTNCVVDNRMVVKIADFGFNTIVSPSED------------LWTAPEHLRK--PGISQKGDVYS 656

  Fly   740 FAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDP-----FRPEV--ESIIEAESCPDYVL 797
            ||||..||..||     ..|......|..:|| .:.:.|     |||::  ||..|:|   :.|.
Zfish   657 FAIISQEIMMRK-----CTFYTNTCSDRAEKL-ARVQYPSTTSFFRPDLNFESTSESE---EEVC 712

  Fly   798 ACIRDCWAEDPEERPEFSVIRNRLKKM---RGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLC 859
            ..||:||.|||:.||:|..|...|.|:   ...:.::.|:.::..::.|:.|||.:|.|||.|..
Zfish   713 MLIRNCWDEDPDRRPDFKKIEIALWKIVSRDNQEHESYMENLIRRLQMYSRNLERLVEERTALYK 777

  Fly   860 EEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDL 924
            .|:.:.:.|...:||..|...|.....|||..:|.||||||||||||.:...|||::||:.|||:
Zfish   778 AERDRADCLNFMLLPGPVVRSLKETGKVEPELFDEVTIYFSDIVGFTTLCHFSTPMEVVDMLNDI 842

  Fly   925 YTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETL 989
            |..||.|:..:|||||||||||||||||||.:||:|||.:|..|||::|..:...:::|.|...:
Zfish   843 YKNFDSILDNHDVYKVETIGDAYMVVSGLPRRNGNRHAKDICLMALDILAFMGTIQLSHLPGIPV 907

  Fly   990 KLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITE 1054
            .:|||:|:||..|||||:.|||||||||||||||||||.|..|:||:|......|.:....:..|
Zfish   908 WIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSQSTINILQRTDCKFEYE 972

  Fly  1055 KRGLVNMKGKGDVVTWWLTG-ANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHF 1118
            :||...:||||..:|:|||| ..||         .::|.|  ........|..|..:.....:..
Zfish   973 ERGETFLKGKGKEMTYWLTGVTGEN---------YNLPTP--PTAENFQNLQQDLSEMIKTCLQK 1026

  Fly  1119 CGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMVSKRDRDRERPPINGLGAGHFV 1173
            ..:|..|:.|:              |.|....||.......::|....|..|.|:
Zfish  1027 RPSGLWRRKTL--------------SARHRKLMVGVEMETTDQPEYLHLATGDFL 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	38/268 (14%)
		ANF_receptor	48..412	CDD:279440	30/235 (13%)
		PK_GC-A_B	543..827	CDD:270944	94/304 (31%)
		HNOBA	<835..881	CDD:285003	14/45 (31%)
		CYCc	860..1052	CDD:214485	101/191 (53%)
		Guanylate_cyc	887..1074	CDD:278633	105/186 (56%)
gucy2cb	XP_021329920.1	Periplasmic_Binding_Protein_Type_1	33..408	CDD:324556	41/286 (14%)
		PKc_like	471..741	CDD:328722	95/309 (31%)
		CYCc	778..970	CDD:214485	101/191 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910