DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and ADCY10

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	266	Identity:	60/266 - (22%)
Similarity:	109/266 - (40%)	Gaps:	73/266 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   785 SIIEAESCPDYVLACIRDCWAEDPEERPEFSV------IRNRLKKMRGGKTKNIM--------DQ 835
            |:||.||.||.  ..::..:.:.|   |.|:.      ....:.....|:.||::        |.
Human   200 SMIEIESVPDQ--RAVKVNFLKPP---PNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDP 259

  Fly   836 MMEM-MEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYF 899
            .:|| ::||.  :|.|:              :.:.::.|...::|       :.||:...|.:.|
Human   260 ELEMSLQKYV--MESIL--------------KQIDNKQLQGYLSE-------LRPVTIVFVNLMF 301

  Fly   900 SDIVGFTAMSAESTPLQVVNFLNDLY---TVFDRIIRGYDVYKVETI--GDAYMVVSGLPIKNGD 959
            .|         :....::...:.|.|   |...:|.:| .:.||...  |.:::.|.|.|   |:
Human   302 ED---------QDKAEEIGPAIQDAYMHITSVLKIFQG-QINKVFMFDKGCSFLCVFGFP---GE 353

  Fly   960 RHAGEIA---SMALELLHAVKQ-HRIAHRPNETLKLRIGMHTGPVVAGVVGLTM-PRYCLFGDTV 1019
            :...|:.   ..|:::.....| |:|     :|:.  ||:.:|.|..|:||.|: ..|.:.|..|
Human   354 KVPDELTHALECAMDIFDFCSQVHKI-----QTVS--IGVASGIVFCGIVGHTVRHEYTVIGQKV 411

  Fly  1020 NTASRM 1025
            |.|:||
Human   412 NLAARM 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	10/47 (21%)
		HNOBA	<835..881	CDD:285003	8/46 (17%)
		CYCc	860..1052	CDD:214485	40/176 (23%)
		Guanylate_cyc	887..1074	CDD:278633	38/149 (26%)
ADCY10	NP_060887.2	CHD	40..214	CDD:143636	7/15 (47%)
		AcyC	<42..197	CDD:225025
		CHD	292..461	CDD:143636	37/146 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900