Protein Alignment Gyc76C and npr1b

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_009290669.2
• Gene: npr1b / 555911
• ZFINID: ZDB-GENE-100805-4
• Length: 1070
• Species: Danio rerio
• Alignment Length: 1094
• Identity: 397/1094 - (36%)
• Similarity: 592/1094 - (54%)
• Gaps: 162/1094 - (14%)

  Fly    46 ISGALTMALDEVNKDPNLLP-----NVYLDLRWNDTKGDTVLATKAITEMICD-----GIATIFG 100
            :..||..|:..||.:|||||     :|:.    |....|.:.:......|..|     ......|
Zfish    68 VGPALDRAIARVNANPNLLPRHRVRHVFA----NSEDRDGICSESMAPLMAVDLKFEHNPWAFIG 128

  Fly   101 PEGPCYVEA---IVSQSRNIPMISY---KCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWN 159
            | |..|..:   :.:....:|||:.   ..|..:.....:...|.|...::.:..|.|.|::.||
Zfish   129 P-GCDYTSSPVGLFTAHWGLPMITAGAPAVAFLQMEIYTSITNTGPTHKKLGEYALHLYRHFGWN 192

  Fly   160 KFSIL------------YEDVWSPVADLLKDQATKRNMTINHKQSFI-----------DNRVKCC 201
            :.|:|            |..:.....::.::..|..::.....:..:           |.||
Zfish   193 QHSLLMFSDTKMGERACYFALEGLYTEMHEENITTMDLVFEENKGPVNYSELLHKIQGDGRV--- 254

  Fly   202 EQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYS- 265
              :..||....:.||:                   |.|    ..||| .:.||:..::|:..:|
Zfish   255 --VFVCCSPDVFRQLI-------------------VHF----HKAGL-PKEEYVFFYIDIFGHSF 293

  Fly   266 -EREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLE 329
             .|.::.:.|......|     :.|.|..:.   ::....|..::|..|...: |..:|..||..
Zfish   294 RSRPSQPWARGDSDDVF-----AKEAFQSVK---ILTYLEPQNQEYKDFVTDL-KSDAKRMFNFT 349

  Fly   330 IPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIK- 393
            :.        ...::|.:...||.:.||..|:::.|.:.         .|..|.     :::.|
Zfish   350 VD--------DSLMNIISGGFYDGLMLYCHALNESLSDS---------HERPSG-----ESVSKR 392

  Fly   394 --NRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKL 456
              ||||..:|| .::||:.||.|.:|::       |:.::....::.:|.|   :.|.: .|..:
Zfish   393 MWNRTYYGVTG-LVQIDENGDRETDFAL-------WDMADINTGDFQIVAV---YNGTQ-KEMNI 445

  Fly   457 ING-SIDWPSGGEKPADEPMCGFANE--LCKKDDTHYTSTVA-----AVVLGVLLFCSGVITMSI 513
            :.| :|.|| ||:.|.|.|.|||.||  .|:      ..|:|     ::||.::|.....:|:.|
Zfish   446 LPGMAIQWP-GGKVPMDVPTCGFKNENPACR------ARTIAMHQMISIVLFLILIIIFTVTVFI 503

  Fly   514 YRKWKIELEIEGLLWKIDPNEIK-GYSGNEIVSSPSKVSL-MSAQSYGSRWTN----QFVTSTGR 572
            |||.|:|.|:...||:|..::|: .:....:.|:.||::| :...:|||..|.    |....||.
Zfish   504 YRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGSKLTLSLRGSNYGSLLTTDGNFQVFAKTGY 568

  Fly   573 LRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYD 637
            .:|.:|.||.:. .|:.:::|:::.|::.:|:::::::..||||.::|..|.:||:||.:|||.:
Zfish   569 FKGNIVAIKYIN-RRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQN 632

  Fly   638 IIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQC 702
            |:||:.|.||.:|..|||.|::|||.::|||.:|.|||||||||||.:|::|::||:||..:|
Zfish   633 ILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIR-- 695

  Fly   703 AENESIGEHQHYRNQLWRAPELLRNHIH---GSQKGDVYAFAIIMYEIFSRKGPF---GQINFEP 761
            .|:::...|.:|..:||.||||.|....   |:||||||:|.||:.|:..|:|.|   |.: ..|
Zfish   696 TESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDL-LSP 759

  Fly   762 KEIVDYVKKLPLKGEDPF-RPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMR 825
            |||||.|    ..||.|: ||.:.....:|....    .::.||||:|.:|||||.|...|:|..
Zfish   760 KEIVDRV----ALGEWPYLRPSLNPQAHSEELGQ----LMQRCWAEEPSDRPEFSHISVLLRKQN 816

  Fly   826 GGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPV 890
            .....||:|.::..||:||||||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..
Zfish   817 REHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAE 881

  Fly   891 SYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPI 955
            ::|.||||||||||||::||||||||||..||||||.||.||..:|||||||||||||||||||:
Zfish   882 AFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPV 946

  Fly   956 KNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVN 1020
            :||..|..|||.|:|.||.|||..:|.|||:|.||||||:|:|||.||||||.||||||||||||
Zfish   947 RNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVN 1011

  Fly  1021 TASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            |:||||||||.||||:|:..:..|.:. ..:..|.||.|.|||||.:.|:||.|
Zfish  1012 TSSRMESNGEPLKIHVSSATRAVLQEF-NCFQLELRGDVEMKGKGKMRTYWLLG 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	87/442 (20%)
		PK_GC-A_B	543..827	CDD:270944	119/295 (40%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	129/191 (68%)
npr1b	XP_009290669.2	Periplasmic_Binding_Protein_type1	50..453	CDD:471960	91/461 (20%)
		PK_GC-A_B	544..818	CDD:270944	115/285 (40%)
		HNOBA	<818..872	CDD:462234	28/53 (53%)
		CYCc	851..1036	CDD:214485	128/184 (70%)