DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and npr1b

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	1094	Identity:	397/1094 - (36%)
Similarity:	592/1094 - (54%)	Gaps:	162/1094 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ISGALTMALDEVNKDPNLLP-----NVYLDLRWNDTKGDTVLATKAITEMICD-----GIATIFG 100
            :..||..|:..||.:|||||     :|:.    |....|.:.:......|..|     ......|
Zfish    68 VGPALDRAIARVNANPNLLPRHRVRHVFA----NSEDRDGICSESMAPLMAVDLKFEHNPWAFIG 128

  Fly   101 PEGPCYVEA---IVSQSRNIPMISY---KCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWN 159
            | |..|..:   :.:....:|||:.   ..|..:.....:...|.|...::.:..|.|.|::.||
Zfish   129 P-GCDYTSSPVGLFTAHWGLPMITAGAPAVAFLQMEIYTSITNTGPTHKKLGEYALHLYRHFGWN 192

  Fly   160 KFSIL------------YEDVWSPVADLLKDQATKRNMTINHKQSFI-----------DNRVKCC 201
            :.|:|            |..:.....::.::..|..::.....:..:           |.||
Zfish   193 QHSLLMFSDTKMGERACYFALEGLYTEMHEENITTMDLVFEENKGPVNYSELLHKIQGDGRV--- 254

  Fly   202 EQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYS- 265
              :..||....:.||:                   |.|    ..||| .:.||:..::|:..:|
Zfish   255 --VFVCCSPDVFRQLI-------------------VHF----HKAGL-PKEEYVFFYIDIFGHSF 293

  Fly   266 -EREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLE 329
             .|.::.:.|......|     :.|.|..:.   ::....|..::|..|...: |..:|..||..
Zfish   294 RSRPSQPWARGDSDDVF-----AKEAFQSVK---ILTYLEPQNQEYKDFVTDL-KSDAKRMFNFT 349

  Fly   330 IPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIK- 393
            :.        ...::|.:...||.:.||..|:::.|.:.         .|..|.     :::.|
Zfish   350 VD--------DSLMNIISGGFYDGLMLYCHALNESLSDS---------HERPSG-----ESVSKR 392

  Fly   394 --NRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKL 456
              ||||..:|| .::||:.||.|.:|::       |:.::....::.:|.|   :.|.: .|..:
Zfish   393 MWNRTYYGVTG-LVQIDENGDRETDFAL-------WDMADINTGDFQIVAV---YNGTQ-KEMNI 445

  Fly   457 ING-SIDWPSGGEKPADEPMCGFANE--LCKKDDTHYTSTVA-----AVVLGVLLFCSGVITMSI 513
            :.| :|.|| ||:.|.|.|.|||.||  .|:      ..|:|     ::||.::|.....:|:.|
Zfish   446 LPGMAIQWP-GGKVPMDVPTCGFKNENPACR------ARTIAMHQMISIVLFLILIIIFTVTVFI 503

  Fly   514 YRKWKIELEIEGLLWKIDPNEIK-GYSGNEIVSSPSKVSL-MSAQSYGSRWTN----QFVTSTGR 572
            |||.|:|.|:...||:|..::|: .:....:.|:.||::| :...:|||..|.    |....||.
Zfish   504 YRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGSKLTLSLRGSNYGSLLTTDGNFQVFAKTGY 568

  Fly   573 LRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYD 637
            .:|.:|.||.:. .|:.:::|:::.|::.:|:::::::..||||.::|..|.:||:||.:|||.:
Zfish   569 FKGNIVAIKYIN-RRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQN 632

  Fly   638 IIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQC 702
            |:||:.|.||.:|..|||.|::|||.::|||.:|.|||||||||||.:|::|::||:||..:|
Zfish   633 ILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIR-- 695

  Fly   703 AENESIGEHQHYRNQLWRAPELLRNHIH---GSQKGDVYAFAIIMYEIFSRKGPF---GQINFEP 761
            .|:::...|.:|..:||.||||.|....   |:||||||:|.||:.|:..|:|.|   |.: ..|
Zfish   696 TESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDL-LSP 759

  Fly   762 KEIVDYVKKLPLKGEDPF-RPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMR 825
            |||||.|    ..||.|: ||.:.....:|....    .::.||||:|.:|||||.|...|:|..
Zfish   760 KEIVDRV----ALGEWPYLRPSLNPQAHSEELGQ----LMQRCWAEEPSDRPEFSHISVLLRKQN 816

  Fly   826 GGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPV 890
            .....||:|.::..||:||||||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..
Zfish   817 REHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAE 881

  Fly   891 SYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPI 955
            ::|.||||||||||||::||||||||||..||||||.||.||..:|||||||||||||||||||:
Zfish   882 AFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPV 946

  Fly   956 KNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVN 1020
            :||..|..|||.|:|.||.|||..:|.|||:|.||||||:|:|||.||||||.||||||||||||
Zfish   947 RNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVN 1011

  Fly  1021 TASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            |:||||||||.||||:|:..:..|.:. ..:..|.||.|.|||||.:.|:||.|
Zfish  1012 TSSRMESNGEPLKIHVSSATRAVLQEF-NCFQLELRGDVEMKGKGKMRTYWLLG 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	87/442 (20%)
		ANF_receptor	48..412	CDD:279440	80/407 (20%)
		PK_GC-A_B	543..827	CDD:270944	119/295 (40%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	129/191 (68%)
		Guanylate_cyc	887..1074	CDD:278633	126/186 (68%)
npr1b	XP_009290669.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710