DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	682	Identity:	179/682 - (26%)
Similarity:	278/682 - (40%)	Gaps:	214/682 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 KWKIELEIEG-LLWKIDPNEIKGYSGNEIVSSPSKVSLMSA----QSYGSRWTNQFVTSTG---- 571
            |.:.:|:.|| .|.:|..::.|.|   ::|::.|||..::|    |.:|..:. .|...:|
Mouse    26 KKEAQLDEEGQFLVRIIYDDSKTY---DLVAAASKVLNLNAGEILQMFGKMFF-VFCQESGYDTI 86

  Fly   572 -RLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNI---------NSFIGASVEPTRILLV 626
             |:.|:.|              ||.::.:..|    ||::         .||.....|..:.|::
Mouse    87 LRVLGSNV--------------REFLQNLDAL----HDHLATIYPGMRAPSFRCTDAEKGKGLIL 133

  Fly   627 TDYCAKGSLYDI-----------------------------------IENEDIKLDDLFIASLIH 656
            ..|..:..|.||                                   ||.::.|.:|.:     .
Mouse   134 HYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFY-----E 193

  Fly   657 DLIK----------------------GMIYIHNSQLVYHGN--------LKSSNCVVTSRWMLQV 691
            ||.:                      .:|:..|..:...||        |:..||.:.|.:
Mouse   194 DLDRFEENGTQESRISPYTFCKAFPFHIIFDRNLVVTQCGNAIYRVLPQLQPGNCSLLSVF---- 254

  Fly   692 TDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMY--EIFSRKGPF 754
                                           .|:|.||      |:....|:.:  .:|..:...
Mouse   255 -------------------------------SLVRPHI------DISFHGILSHINTVFVLRSKE 282

  Fly   755 GQINFEPKEIVD-----YVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEF 814
            |.::.|..|..|     .:..|.|||:..:.||.:||:         ..|.......|...|
Mouse   283 GLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSIL---------FLCSPSVMNLDDLTR--- 335

  Fly   815 SVIRNRLKKMRG---------GKTKNIMDQMMEMMEKYANNLE-DIVTERTRL----LCEEKMKT 865
                      ||         ..|::::....:..|:|....| :|:|:|.:|    |.:||.||
Mouse   336 ----------RGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKT 390

  Fly   866 EDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAEST----PLQVVNFLNDLYT 926
            :.||:.:||.|||.:|...:.|....||.|||.||.||||.|..::..    .:::||.||||||
Mouse   391 DTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYT 455

  Fly   927 VFDRII---RGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNET 988
            .||.:.   :...||||||:||.||.||||| :....||..|..:||:::....|.::   ..|:
Mouse   456 RFDTLTDSRKNPFVYKVETVGDKYMTVSGLP-EPCIHHARSICHLALDMMEIAGQVQV---DGES 516

  Fly   989 LKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISN---KCKLALDKLGGG 1050
            :::.||:|||.||.||:|..||||||||:|||..||.|:.||..||::|.   :|.::.:.....
Mouse   517 VQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPL 581

  Fly  1051 YITEKRGLVNMKGKGDVVTWWL-----TGANE 1077
            :..|.||.|:||||.:.:..|.     ||..|
Mouse   582 FHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	63/382 (16%)
		HNOBA	<835..881	CDD:285003	19/50 (38%)
		CYCc	860..1052	CDD:214485	87/201 (43%)
		Guanylate_cyc	887..1074	CDD:278633	84/201 (42%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572	33/161 (20%)
		HNOBA	207..406	CDD:311573	52/261 (20%)
		Guanylate_cyc	412..605	CDD:306677	84/196 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810