DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	146/745 - (19%)
Similarity:	252/745 - (33%)	Gaps:	259/745 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 EPKE-----IVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFS-VIR 818
            ||.|     :.||:.:|..  |||.|     |.|..:.||  |:|:...:.|.|.:..... ::.
  Rat   134 EPTERPLQIVYDYLSRLGF--EDPVR-----IQEEATNPD--LSCMIRFYGEKPCQMDHLDRILL 189

  Fly   819 NRLKKMRGGKTKNIMDQMMEMMEKYANNL-------------EDIVTERTRLLCEEKMKTEDLLH 870
            :.:..:|.|||:         :.|:|..|             :|..|.:..:|.....|.|::..
  Rat   190 SGIYNVRKGKTQ---------LHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKR 245

  Fly   871 RMLPQSVAEKLTMGQGVEPVSYDLVTIY------FSDIVG-------FTAMSAESTP-----LQV 917
            |....:.:......|... ||::.:..|      .|.:|.       .:..|.|..|     .|.
  Rat   246 RQHSLAFSSAGAQAQTYH-VSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQD 309

  Fly   918 VNFLNDLYTVFDRIIR--GYD-VYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQH 979
            :.:|| |...|.::.|  |.| :||       :..:.||.:.:  ...|....:..|:
  Rat   310 ITYLN-LRHNFMQLERPGGLDTLYK-------FSQLKGLNLSH--NKLGLFPVLLCEI------- 357

  Fly   980 RIAHRPNETL-KLRI---GMHTGPVVAGVVGLTMPRYCLFG-------DTVNTASRMESNG---- 1029
                   .|| :|.:   |.|..|...|.: |.:...||.|       |.:....::.|.|
  Rat   358 -------STLTELNLSCNGFHDLPSQIGNL-LNLQTLCLDGNVLTALPDELGNLQQLTSLGISFN 414

  Fly  1030 ------EAL-KIHISNKCKLA---LDKLGGGYITE----KRGLVNMKGKGDVVTWWLTGANENAI 1080
                  |.| |:.:.:|..:|   |:.|..|.:|.    |...:.|.....|:.       ||..
  Rat   415 NFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVDLRMNHLKTVII-------ENLE 472

  Fly  1081 QKKLVDMMDMPPPLFSRPRKSPKLNPD-SRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQG- 1143
            ..|.:..||:        |.:...:.| |...|::.:| |.....|:.|:       |.:||:.
  Rat   473 GNKHITHMDL--------RDNQLTDLDLSSLCSLEQLH-CERNQLRELTL-------SGFSLRNL 521

  Fly  1144 ----------SVRESPRMVSKRDRDRERPPINGLGAGHFVGGALL--------ESAQASLSTLNH 1190
                      :|...|.:::..:..|.                ||        |:.:..:..:::
  Rat   522 YANWNKLTAVNVYPVPSLLTSLELSRN----------------LLECIPDWACEAKKLEILDISY 570

  Fly  1191 SETNETNCDMDGGSGGVSGSGSGLVRQPNALHKPLAMVRPHRIISAAQLPQL--GDNDDDSADTL 1253
            :...|.                                 |.||:|:..|.:|  |.|.......|
  Rat   571 NLLTEV---------------------------------PMRILSSLSLRKLMVGHNHIHVLPAL 602

  Fly  1254 LRESRSLDPMPMQQLRKRHDRV-KLPPSKLSKN-NSRSLDTGVSLISGNPN---GEVHSSQLDL- 1312
                  ::.:|::.|..:|:.: :||.:..||. |.|.|:...:.:...|:   ||...|.|.|
  Rat   603 ------VEHIPLEVLDVQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAGEESLSVLQLL 661

  Fly  1313 ---DNEMTANPVDATDGYDDELGLLMRHDN-------------GQLPALRYSGSFPNAQISIVPT 1361
               :|.:|...:....|: ..|.:|...:|             .||..|..||:    ::..:||
  Rat   662 YLTNNLLTDQCIPVLVGH-PHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGN----KLKAIPT 721

  Fly  1362 GRSAGGGGGGREGGGSNCAK------HLNN 1385
            ..             :||.:      |.||
  Rat   722 TI-------------ANCKRLHTLVAHANN 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	19/72 (26%)
		HNOBA	<835..881	CDD:285003	9/58 (16%)
		CYCc	860..1052	CDD:214485	48/237 (20%)
		Guanylate_cyc	887..1074	CDD:278633	48/236 (20%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761	17/52 (33%)
		PH_PHLPP-like	185..279	CDD:270131	17/103 (17%)
		PLN00113	284..>762	CDD:215061	109/576 (19%)
		leucine-rich repeat	289..309	CDD:275380	3/19 (16%)
		leucine-rich repeat	310..336	CDD:275380	9/33 (27%)
		leucine-rich repeat	337..359	CDD:275380	4/37 (11%)
		leucine-rich repeat	360..382	CDD:275380	6/22 (27%)
		leucine-rich repeat	383..405	CDD:275380	4/21 (19%)
		leucine-rich repeat	406..428	CDD:275380	5/21 (24%)
		leucine-rich repeat	429..452	CDD:275380	6/22 (27%)
		leucine-rich repeat	453..476	CDD:275380	5/29 (17%)
		leucine-rich repeat	477..497	CDD:275380	5/27 (19%)
		leucine-rich repeat	498..517	CDD:275380	5/26 (19%)
		leucine-rich repeat	518..539	CDD:275380	3/20 (15%)
		leucine-rich repeat	540..562	CDD:275380	4/37 (11%)
		leucine-rich repeat	563..584	CDD:275380	5/53 (9%)
		leucine-rich repeat	586..607	CDD:275380	5/26 (19%)
		leucine-rich repeat	608..631	CDD:275380	6/22 (27%)
		leucine-rich repeat	632..681	CDD:275380	11/49 (22%)
		leucine-rich repeat	682..705	CDD:275380	3/22 (14%)
		leucine-rich repeat	706..728	CDD:275380	8/38 (21%)
		leucine-rich repeat	751..772	CDD:275380
		PP2Cc	820..1069	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900