DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and NPR2

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	1169	Identity:	399/1169 - (34%)
Similarity:	592/1169 - (50%)	Gaps:	231/1169 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ISGALTMALDEVNKDPNLLPNVYLDLRW--NDTKG---DTVLATKAITEMICDGIATIFGPEGPC 105
            :..|:.:|::.:.:   .||   :|||:  ::.:|   :.:....|:...:......:.|| |..
Human    45 VGPAVALAVEALGR---ALP---VDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGP-GCV 102

  Fly   106 YVEAIVSQSRN---IPMI---------SYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAW 158
            |..|.|::..:   :|::         |.|...||     |..||.|...::.:.::.|..::.|
Human   103 YPAASVARFASHWRLPLLTAGAVASGFSAKNDHYR-----TLVRTGPSAPKLGEFVVTLHGHFNW 162

  Fly   159 N-KFSILYEDVWSP----------VADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGY 212
            . :.::||.|..:.          |.:.|:..    |:::.|:              :.....|.
Human   163 TARAALLYLDARTDDRPHYFTIEGVFEALQGS----NLSVQHQ--------------VYAREPGG 209

  Fly   213 WYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSE----------- 266
            ..|.........||....|....|.:.:...:...| ..|:|:..::|  |:.|
Human   210 PEQATHFIRANGRIVYICGPLEMLHEILLQAQRENL-TNGDYVFFYLD--VFGESLRAGPTRATG 271

  Fly   267 --------REAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSK 323
                    ||..:.||...|..                 |::....||..:|.:|..:: ...::
Human   272 RPWQDNRTREQAQALREAFQTV-----------------LVITYREPPNPEYQEFQNRL-LIRAR 318

  Fly   324 PPFNLEI-PRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLRE-ETRVLTDDVIFEVASNGTR 386
            ..|.:|: |.|         :::.|...||.:.|||..:::.::| .||           .:|.|
Human   319 EDFGVELGPSL---------MNLIAGCFYDGILLYAEVLNETIQEGGTR-----------EDGLR 363

  Fly   387 VIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEH 451
            :::. ::.|.|..:|| .:.:|:..|.|.:|.:       |...:....::.  |.|::...|:
Human   364 IVEK-MQGRRYHGVTG-LVVMDKNNDRETDFVL-------WAMGDLDSGDFQ--PAAHYSGAEK- 416

  Fly   452 PEYKLINGSIDWPSGGEKPADEPMCGF--ANELCKKDDTHYTSTVAAVVLG-----VLLFCSGVI 509
             :.......|.|..|. .|:|.|.|.|  .:..|.|..   .||:|.|.||     ::...|..:
Human   417 -QIWWTGRPIPWVKGA-PPSDNPPCAFDLDDPSCDKTP---LSTLAIVALGTGITFIMFGVSSFL 476

  Fly   510 TMSIYRKWKIELEIEGLLWKIDPNEIK-GYSGNEIVSSPSKVSL-MSAQSYGSRWT----NQFVT 568
            ....|||..:|.|:..:||:|...|:: |.|......:.|:::| :...||||..|    .|...
Human   477 IFRPYRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFA 541

  Fly   569 STGRLRGAVVRIKELKFPRKR-DISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAK 632
            :||..:|.||.||.:.  :|| :::|:::.|::.:|:::.:::..||||.::|..|.:||:||.:
Human   542 NTGHFKGNVVAIKHVN--KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPR 604

  Fly   633 GSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLH 697
            |||.||:||:.|.||.:|..|||:||:|||.::|||.:..||:||||||||.||::|::||:||.
Human   605 GSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA 669

  Fly   698 ELRQCAENE------SIGEHQH------------------------------------------- 713
            ..|..||.:      :...|.|
Human   670 SFRSTAEPDDSHALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSPGGLGGAPFRGTWPAG 734

  Fly   714 --YRNQLWRAPELLRNH---IHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKL 771
              :..:||.|||||..:   ..|.||.|||:|.||:.||..|.|||  ..::..|||||..|:
Human   735 FLFSEKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVR-- 797

  Fly   772 PLKGEDP-FRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQ 835
              .|:.| |||   ||...:...:.||...| |||:||.|||:|..|:..:::.......:|:|.
Human   798 --NGQRPYFRP---SIDRTQLNEELVLLMER-CWAQDPAERPDFGQIKGFIRRFNKEGGTSILDN 856

  Fly   836 MMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFS 900
            ::..||:||||||.:|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.||||||
Human   857 LLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS 921

  Fly   901 DIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEI 965
            |||||||:||||||:|||..||||||.||.||..:|||||||||||||||||||.:||.|||.||
Human   922 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEI 986

  Fly   966 ASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGE 1030
            |.|||.||.||...||.|||::.|:||||:|||||.||||||.|||||||||||||||||||||:
Human   987 ARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 1051

  Fly  1031 ALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPL 1094
            |||||:|:..|.|||:| |.:..|.||.|.|||||.:.|:||.|..:.            ||.|
Human  1052 ALKIHVSSTTKDALDEL-GCFQLELRGDVEMKGKGKMRTYWLLGERKG------------PPGL 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	81/447 (18%)
		ANF_receptor	48..412	CDD:279440	75/412 (18%)
		PK_GC-A_B	543..827	CDD:270944	122/346 (35%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	137/191 (72%)
		Guanylate_cyc	887..1074	CDD:278633	134/186 (72%)
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556	82/459 (18%)
		PK_GC-A_B	521..848	CDD:270944	120/336 (36%)
		HNOBA	<857..902	CDD:311573	25/44 (57%)
		CYCc	881..1065	CDD:214485	132/183 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710