Protein Alignment Gyc76C and NPR1

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 1140
• Identity: 405/1140 - (35%)
• Similarity: 594/1140 - (52%)
• Gaps: 182/1140 - (15%)

  Fly     8 LLLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLR 72
            |||||.      .:|...|||..:..|...........:..|:.:||.:|...|:|||.
Human    23 LLLLLR------GSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPG------ 75

  Fly    73 WNDTKGDTVLATKAITEMICDGI---------------ATIFGPEGPCYVEAIVSQSR---NIPM 119
            |...   |||.:......:|...               |...|| |..|..|.|.:..   .:|:
Human    76 WTVR---TVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGP-GCVYAAAPVGRFTAHWRVPL 136

  Fly   120 ISYKCA--------EYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSI------------- 163
            ::....        ||   |:.|  |..|...::...:.||.|...|.:.::
Human   137 LTAGAPALGFGVKDEY---ALTT--RAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHC 196

  Fly   164 --LYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRI 226
              |.|.::..|.|.|       |:|::|.:...|:             ..::.:|::....:.|:
Human   197 FFLVEGLFMRVRDRL-------NITVDHLEFAEDD-------------LSHYTRLLRTMPRKGRV 241

  Fly   227 YVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAE-----KYLRRVDQITFMSNCH 286
            .....:.::....|.....|||... :|:...:|:...|.:..:     :...|.|.    .:..
Human   242 IYICSSPDAFRTLMLLALEAGLCGE-DYVFFHLDIFGQSLQGGQGPAPRRPWERGDG----QDVS 301

  Fly   287 STENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLY 351
            :.:.| |.|:  ::....|...:|::|.||: |:.:...||..:.        ...::...|..:
Human   302 ARQAF-QAAK--IITYKDPDNPEYLEFLKQL-KHLAYEQFNFTME--------DGLVNTIPASFH 354

  Fly   352 DSVKLYAWAVDKMLREETRVLTDDVIFEVASNGT----RVIDTIIKNRTYMSITGSKIKIDQYGD 412
            |.:.||..||.:.|               |..||    ..|...:.||::..:|| .:|||..||
Human   355 DGLLLYIQAVTETL---------------AHGGTVTDGENITQRMWNRSFQGVTG-YLKIDSSGD 403

  Fly   413 SEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCG 477
            .|.:||:....|.  |.:..:..||:         |.......:....::||. |..|.|.|.||
Human   404 RETDFSLWDMDPE--NGAFRVVLNYN---------GTSQELVAVSGRKLNWPL-GYPPPDIPKCG 456

  Fly   478 FANE--LCKKDDTHYTSTVAAV----VLGVLLFCSGVITMSIYRKWKIELEIEGLLWK-----ID 531
            |.||  .|.:|.......:|.|    :||:|     :::..||||.::|.|:...||:     ::
Human   457 FDNEDPACNQDHLSTLEVLALVGSLSLLGIL-----IVSFFIYRKMQLEKELASELWRVRWEDVE 516

  Fly   532 PNEIKGYSGNEIVSSPSKVSLMS-AQSYGSRWTN----QFVTSTGRLRGAVVRIKELKFPRKR-D 590
            |:.::    ..:.|:.|:::|.. ..:|||..|.    |....|...:|.:|.:|.:.  ||| :
Human   517 PSSLE----RHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN--RKRIE 575

  Fly   591 ISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLI 655
            ::|:::.|::.:|:::::::..|:||..:|..|.::|:||.:|||.||:|||.|.||.:|..||.
Human   576 LTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLT 640

  Fly   656 HDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWR 720
            :|::|||:::||..:..|||||||||||..|::|::||:||...|.....:.   |..|..:||.
Human   641 NDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQG---HTVYAKKLWT 702

  Fly   721 APELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGED-PF 779
            ||||||   ..:.|||.||||:|.||:.||..|.|.|  ..::..||||::.|    .:||. ||
Human   703 APELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERV----TRGEQPPF 763

  Fly   780 RPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYA 844
            ||.    :..:|..:.:...::.||||||:|||.|..||..|:|.....:.||:|.::..||:||
Human   764 RPS----LALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYA 824

  Fly   845 NNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMS 909
            ||||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.|||||||||||||:|
Human   825 NNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALS 889

  Fly   910 AESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLH 974
            |||||:|||..||||||.||.:|..:|||||||||||||||||||::||..||.|:|.|||.||.
Human   890 AESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLD 954

  Fly   975 AVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNK 1039
            ||:..||.|||.|.|:||||:|||||.||||||.|||||||||||||||||||||||||||:|::
Human   955 AVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSE 1019

  Fly  1040 CKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            .|..|::. ||:..|.||.|.|||||.|.|:||.|
Human  1020 TKAVLEEF-GGFELELRGDVEMKGKGKVRTYWLLG 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	93/468 (20%)
		PK_GC-A_B	543..827	CDD:270944	115/295 (39%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	134/191 (70%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:380608	93/485 (19%)
		PK_GC-A_B	534..807	CDD:270944	112/285 (39%)
		HNOBA	<813..861	CDD:462234	26/47 (55%)
		CYCc	840..1032	CDD:214485	134/192 (70%)