DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and CG3216

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	1172	Identity:	391/1172 - (33%)
Similarity:	595/1172 - (50%)	Gaps:	207/1172 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VLTVGYLTALTGDLKTRQGLAISG-ALTMALDEVNK------------------------DPNLL 64
            |..||.|.|  ..|.:...|...| |:.:||||:||                        .|.|.
  Fly    88 VYNVGVLMA--SHLDSPFDLERCGPAVDLALDEINKVFLKPHNITLLKKKGSYPSCSGARAPGLA 150

  Fly    65 PNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKCAEYRA 129
            .::|..                      |.:....||.....:|.:.           :.|.|..
  Fly   151 ADMYFQ----------------------DDVIAFIGPACAFALEPVA-----------RLAAYWN 182

  Fly   130 SAIPTFARTEPPDTQ----VVKSLLALLRYYAW-----------NKF------------------ 161
            ..|.|....:||.::    |...:|.  |.:.|           :|:
  Fly   183 KPIITGMGDQPPSSEGELTVTSGILG--RIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFA 245

  Fly   162 SILYEDVWSPVADLLKDQA------TKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNT 220
            |::.:..|:.|| ||.|::      ..:|:....:|..:.:.||..        :|...::.:|.
  Fly   246 SVIRQFNWNHVA-LLVDRSELFSWTVGKNLEYGLRQEGLLSFVKEL--------NGNEEEVYENY 301

  Fly   221 MNRTRIY---VFLGAANSLV-DFMSSMETAGLFARGEYMVIFVDMMVY-SEREAEKYLRRVDQIT 280
            :....:|   |.|.....|| .||.:..:.|: ..||:  :|:|:.:: ||...:|.....|:
  Fly   302 LKDASMYARVVILSVRGVLVRKFMLAAHSLGM-TNGEW--VFLDVEIFQSEYWGDKGWEMKDE-- 361

  Fly   281 FMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISI 345
              .:..:.:.:..:.|..|:..::|..:|:....::...|.....|...     .|.||  ||..
  Fly   362 --HDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEG-----EEVNF--FIGA 417

  Fly   346 YAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQY 410
            :    ||.|.|...|:::.|.|...: .|.|      |.||    .:.|||:..||| .::||..
  Fly   418 F----YDGVYLLGMALNETLTEGGDI-RDGV------NITR----RMWNRTFEGITG-HVRIDDN 466

  Fly   411 GDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLING-SIDWPSGGEK-PADE 473
            ||.:.::|:|...          |.|.....||  |....|..|..::| .|.||.|.|: |.|.
  Fly   467 GDRDADYSILDLD----------PINGKFSVVA--HYSGVHKVYSAVHGKKIHWPGGREEPPPDV 519

  Fly   474 PMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSI---YRKWKIELEIEGLLWKIDPN-- 533
            |.|||...  ..|.....||:...|.|:|||. |::.:.|   .::.|:..|:..:.|::.|:
  Fly   520 PPCGFLGN--STDCVGNFSTIMYSVFGLLLFL-GLVFLVICLLQKQMKLSKELNNMSWRVRPDDV 581

  Fly   534 --EIKGYSGNEIVSSPSKVSLMSAQSYG--------SRWTN---QFVTSTGRLRGAVVRIKELKF 585
              |:.|..|::.......|..:|.|.:|        :.:|:   |..|:.|:.:|..|.||::..
  Fly   582 LIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNV 646

  Fly   586 PRKRDISREIMKEMRLLRELRHDNINSFIGASVE---PTRILLVTDYCAKGSLYDIIENEDIKLD 647
             :|.|::.:::.|::..|::.|:|...|:||.::   || :|::|:||::|||.|::|||.|:||
  Fly   647 -KKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPT-VLILTEYCSRGSLKDVLENEAIELD 709

  Fly   648 DLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQ 712
            ..|..|||||::|||.|:|||.:..||.|:|.||::..|::|:::||||..|  ...::.:.:..
  Fly   710 WNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTL--TTPSDFVRDQN 772

  Fly   713 HYRNQLWRAPELL-RNHIHG----SQKGDVYAFAIIMYEIFSRKGPFGQI--NFEPKEIVDYVKK 770
            :|...||.||||| ...|.|    :|:||||:|.||:.||.:|.||:.:.  ..:...|:..|::
  Fly   773 YYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ 837

  Fly   771 LPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQ 835
            .     :.|||    :|....||..:|..:..|||::.||||.||.||:.::.:..|..:|:||.
  Fly   838 C-----NGFRP----LIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDD 893

  Fly   836 MMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFS 900
            ::..||:||||||.:|.|:||.|..||.:||:||:::||:.||::|..|..|||..:..||||||
  Fly   894 LLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFS 958

  Fly   901 DIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEI 965
            ||||||.:.|.|:|:.|||||||||:.|||||..|||||||||||||:||||||..|||:||.||
  Fly   959 DIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREI 1023

  Fly   966 ASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGE 1030
            |.|||::|.||....:.|:|...:::|||||:|.|.|||||..||.||||||||||||||||.|:
  Fly  1024 ALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQ 1088

  Fly  1031 ALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQ---KKLVDMMDMPP 1092
            ..|||:|:..|..|||. |.:..|:||.|.:||||.|.|:||...:|...:   .:::...::|.
  Fly  1089 PGKIHVSSATKAILDKF-GTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTPQILTTDEVPF 1152

  Fly  1093 PL 1094
            ||
  Fly  1153 PL 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	100/487 (21%)
		ANF_receptor	48..412	CDD:279440	86/432 (20%)
		PK_GC-A_B	543..827	CDD:270944	106/304 (35%)
		HNOBA	<835..881	CDD:285003	23/45 (51%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	119/186 (64%)
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	101/493 (20%)
		ANF_receptor	107..479	CDD:279440	90/445 (20%)
		PKc_like	616..885	CDD:304357	102/281 (36%)
		TyrKc	627..877	CDD:197581	99/262 (38%)
		HNOBA	<882..939	CDD:285003	27/56 (48%)
		CYCc	918..1109	CDD:214485	119/191 (62%)
		Guanylate_cyc	945..1131	CDD:278633	119/186 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.810