Protein Alignment Gyc76C and GUCY2D

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_000171.1
• Gene: GUCY2D / 3000
• HGNCID: 4689
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1197
• Identity: 369/1197 - (30%)
• Similarity: 539/1197 - (45%)
• Gaps: 221/1197 - (18%)

  Fly     1 MTRWPFNLLLLL--SVAVRDCSNHRTVLTVGYLTALTGD---LKTRQGLAISGALTMALDEVNKD 60
            :.|.|..|||||  ..|:      ..|.|||.|.....|   .:.|..|    |..:|...:|:|
Human    33 LPRLPLLLLLLLLQPPAL------SAVFTVGVLGPWACDPIFSRARPDL----AARLAAARLNRD 87

  Fly    61 PN----------LLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGP--CYVEAIVSQ 113
            |.          |||...      .|.|.....:.|:..     ::.:.||..|  |....::::
Human    88 PGLAGGPRFEVALLPEPC------RTPGSLGAVSSALAR-----VSGLVGPVNPAACRPAELLAE 141

  Fly   114 SRNIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY--EDVWSPVADLL 176
            ...|.::.:.|...:|.     ..|.|..|....:|.||||.:.|.:.:::.  :|:|......|
Human   142 EAGIALVPWGCPWTQAE-----GTTAPAVTPAADALYALLRAFGWARVALVTAPQDLWVEAGRSL 201

  Fly   177 KDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMS 241
            ......|.:.:....|.....:....:.|...|.|.....|...|:.    |.||...... .:.
Human   202 STALRARGLPVASVTSMEPLDLSGAREALRKVRDGPRVTAVIMVMHS----VLLGGEEQRY-LLE 261

  Fly   242 SMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARS----LLVVA 302
            :.|..|| ..|..:.:..|.:.|:.....:.|.            :..|.:|:.|:    |.:..
Human   262 AAEELGL-TDGSLVFLPFDTIHYALSPGPEALA------------ALANSSQLRRAHDAVLTLTR 313

  Fly   303 STPPTKDYIQFTKQVQKYSSKP-PFNL-EIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKML 365
            ..|.....:...::.|:....| ..|| ::..||             ..:||:|.|.|..|
Human   314 HCPSEGSVLDSLRRAQERRELPSDLNLQQVSPLF-------------GTIYDAVFLLARGV---- 361

  Fly   366 REETRVLTDDVIFEVASNGTR-----VIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPH 425
             .|.|          |:.|.|     .:...|::.......|     |..||.|..|.:|....
Human   362 -AEAR----------AAAGGRWVSGAAVARHIRDAQVPGFCG-----DLGGDEEPPFVLLDTDA- 409

  Fly   426 KWNNSNNMPCNYHMVPV--AYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGF-ANELCKKDD 487
               ..:.:...|.:.|.  ::...|..          :.:|.||..|..:|.|.| .|.:|...
Human   410 ---AGDRLFATYMLDPARGSFLSAGTR----------MHFPRGGSAPGPDPSCWFDPNNICGGG- 460

  Fly   488 THYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSL 552
                .....|.||.||    |:.|.:...:........||..            ::||.|:|:.|
Human   461 ----LEPGLVFLGFLL----VVGMGLAGAFLAHYVRHRLLHM------------QMVSGPNKIIL 505

  Fly   553 M--------------------SAQSYGSR-------WTNQFVTS--TGRLRGAVVRIKELKFPRK 588
            .                    |..|.|:|       ..:|.:.|  .|...|..|.:|  |||..
Human   506 TVDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLK--KFPGD 568

  Fly   589 RDIS-REIMK-EMRLLRELRHDNINSFIG----------ASVEPTRILLVTDYCAKGSLYDIIEN 641
            :.|: |...| ....|:||||:|:..::|          |::....:.:|:::|.:|||.|::..
Human   569 QHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQ 633

  Fly   642 EDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENE 706
            .:||||.:|.:||:.|||||:.|:|: :.|.||.|||.||:|..|::|::||.|...|.:.  .:
Human   634 REIKLDWMFKSSLLLDLIKGIRYLHH-RGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEA--QK 695

  Fly   707 SIGEHQHYRNQLWRAPELLRN---HIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYV 768
            .:.|.....:|||.||||||:   ...|:..|||::.||||.|:..|..|:..:...|:|:|..|
Human   696 VLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRV 760

  Fly   769 KKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIM 833
            :..|        |....::..:..|...:..::.||||.||.||......:..|.:..|:..||:
Human   761 RSPP--------PLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNII 817

  Fly   834 DQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIY 898
            |.|:.|:|:|::||||::.|||..|..||.||:.||.:|||.||||.|..|..|||..::.||:|
Human   818 DSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLY 882

  Fly   899 FSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAG 963
            ||||||||.:||.|.|::||:.||||||:||.||..:||||||||||||||.||||.:||.|||.
Human   883 FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAA 947

  Fly   964 EIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESN 1028
            |||:|:|::|.||...|:.|.|...:::|||:|:||.|||||||||||||||||||||||||||.
Human   948 EIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMEST 1012

  Fly  1029 GEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKL--------- 1084
            |...:||::......|..|..||..|.||...:||||...|:||.|  .....|.:
Human  1013 GLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG--RRGFNKPIPKPPDLQPG 1075

  Fly  1085 -----VDMMDMPPPLFSRPRKSPKLNP 1106
                 :.:.::||   .|.||..|..|
Human  1076 SSNHGISLQEIPP---ERRRKLEKARP 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	86/448 (19%)
		PK_GC-A_B	543..827	CDD:270944	101/327 (31%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	118/191 (62%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594	86/450 (19%)
		PK_GC-2D	536..811	CDD:270945	92/287 (32%)
		HNOBA	<820..865	CDD:462234	25/44 (57%)
		CYCc	846..1036	CDD:214485	117/189 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1065..1103		7/38 (18%)