DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc76C and Adcy8

DIOPT Version :9

Sequence 1:NP_001163473.1 Gene:Gyc76C / 8674026 FlyBaseID:FBgn0266136 Length:1525 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:1185 Identity:255/1185 - (21%)
Similarity:417/1185 - (35%) Gaps:393/1185 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 YEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMN----RTR 225
            |..|..|.   |::....|::...:::.|:..|.|.              ::|.|.::    .|.
  Rat   146 YRGVIFPT---LRNSFKSRDLERLYQRYFLGQRRKS--------------EVVMNVLDVLTKLTL 193

  Fly   226 IYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTEN 290
            :.:.|..|::.:|.:..: ..|.|. |..:||...::|..:..:..||:....:|:::..     
  Rat   194 LVLHLSLASAPMDPLKGI-LLGFFT-GIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMT----- 251

  Fly   291 FNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKP------------------PFNLEIPRLFVES 337
             .|:..:.|..........|:.|| ....||..|                  ...:.||||.|  
  Rat   252 -TQILAAGLGYGLLGDGIGYVLFT-LFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAV-- 312

  Fly   338 NFS--------------KFISIYAAYLYDSVKLYAW-----AVDKMLREETR----------VLT 373
             ||              ....|:.:||.|..:..|:     .|:..||.||.          ||.
  Rat   313 -FSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLP 376

  Fly   374 DDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYH 438
            ..|:.|:.::.|.|.|..::::.:      :|.|.:|    .|.|:|......:.|.:.......
  Rat   377 RFVVLEMINDMTNVEDEHLQHQFH------RIYIHRY----ENVSILFADVKGFTNLSTTLSAQE 431

  Fly   439 MVPV-----AYFHQ-GEEHP--EYKLINGSIDWPSGGEKP-ADEPMC------------GFANEL 482
            :|.:     |.|.: ..||.  ..|::.......||..:| .|...|            .|....
  Rat   432 LVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSR 496

  Fly   483 CKKD-DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSS 546
            .|.| |........:|:.|||    |:      |||:.::    ..|.:|       ..|::.|.
  Rat   497 TKHDVDMRIGIHSGSVLCGVL----GL------RKWQFDV----WSWDVD-------IANKLESG 540

  Fly   547 --PSKVSLMSA------------QSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDIS--REI 595
              |.::.:..|            :.:|.. .|:|      ||...:....:|.|.:..:|  .:|
  Rat   541 GIPGRIHISKATLDCLSGDYNVEEGHGKE-RNEF------LRKHNIETYLIKQPEESLLSLPEDI 598

  Fly   596 MKEM----------------RLLRELRHDNINSFIG-----ASVEPTRILLVTDYCAKGSLY--- 636
            :||.                ....||..|||   :|     |::....|.|:.::.|: :|:   
  Rat   599 VKESVSCSDRRNSGATFTEGSWSPELPFDNI---VGKQNTLAALTRNSINLLPNHLAQ-ALHVQS 659

  Fly   637 ------------------DIIENEDIKLDDLFI--ASLIHDLIKGMIYIHNSQLVYHGNLKSSNC 681
                              |.:..|.||...|..  :||.|.      |......|:..||..:..
  Rat   660 GPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHK------YSQMRDEVFKSNLVCAFI 718

  Fly   682 VV-----------TSRWMLQVTDFG----LHE-----------------LRQ--CAENESIGEHQ 712
            |:           :||.|.....|.    ||.                 ||:  |..||:.    
  Rat   719 VLLFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETY---- 779

  Fly   713 HYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEI----VDYVKKLPL 773
                       |.||         |..||.|:            |||....|    .|:.|.:||
  Rat   780 -----------LARN---------VIIFASIL------------INFLGAVINILWCDFDKSIPL 812

  Fly   774 KGEDPFRPEVESIIEAESC--PDY-----VLACIRDCWAEDPEERPEFSVIRNRLK--------- 822
            |.. .|.   .|.:..:.|  |:|     |||.: .|        ..|..:.:.||         
  Rat   813 KNL-TFN---SSAVFTDICSYPEYFVFTGVLAMV-TC--------AVFLRLNSVLKLAVLLIMIA 864

  Fly   823 -------------------------KMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEK 862
                                     ...|.|..:::...|.::..:.:..:...|.|...|...:
  Rat   865 IYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQ 929

  Fly   863 MK------------TEDLLHRMLPQSVA----EKLTMGQGVEPVSYDLVTIYFSDIVGF------ 905
            .|            .|::|..:||..||    ||....:.:...|||.|.:.|:.|.||      
  Rat   930 AKEEINEMKDLREHNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQ 994

  Fly   906 TAMSAESTPLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDAYMVVSGL-PIKN--GDR--HA 962
            |.|:.:.  ::.:..||::...||.::   |..|:.|::|||..||.|||| |.|.  .|:  |.
  Rat   995 TEMNNQG--VECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHL 1057

  Fly   963 GEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMES 1027
            ..:|..:|.|..::::  |........:||||:..|.|||||:|...|:|.::|.|||.||||:|
  Rat  1058 CALADFSLALTESIQE--INKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDS 1120

  Fly  1028 NGEALKIHISNKCKLAL-DKLGGGYITEKRGLVNMKG----KGDVVTWWLTGANENAIQKKLVDM 1087
            .|.:.:|.:..:..|.| |:   |:..:.||.:.:||    :|.:.|::|.|..:          
  Rat  1121 TGVSGRIQVPEETYLILKDQ---GFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQ---------- 1172

  Fly  1088 MDMPPPLFSRPRKSP 1102
               |.|....||:.|
  Rat  1173 ---PNPFILPPRRLP 1184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc76CNP_001163473.1 PBP1_Speract_GC_like 26..445 CDD:107365 64/335 (19%)
ANF_receptor 48..412 CDD:279440 58/297 (20%)
PK_GC-A_B 543..827 CDD:270944 77/422 (18%)
HNOBA <835..881 CDD:285003 12/61 (20%)
CYCc 860..1052 CDD:214485 71/222 (32%)
Guanylate_cyc 887..1074 CDD:278633 69/205 (34%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179 8/49 (16%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117
AC_N <158..397 CDD:292831 51/264 (19%)
CYCc 363..561 CDD:214485 43/228 (19%)
Guanylate_cyc 402..586 CDD:278633 41/215 (19%)
DUF1053 614..708 CDD:283888 20/103 (19%)
CYCc 941..1145 CDD:214485 70/210 (33%)
Guanylate_cyc 970..1169 CDD:278633 69/205 (34%)
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248 28/95 (29%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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