DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and Adcy10

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	369	Identity:	74/369 - (20%)
Similarity:	135/369 - (36%)	Gaps:	120/369 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 GDVYAFA----IIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDY 795
            ||:..||    :.:::: .||        :.|.|:..|.|..|        |:..:.||:..
Mouse    91 GDILKFAGDALLALWKV-ERK--------QLKNIITVVIKCSL--------EIHGLFEAKEA--- 135

  Fly   796 VLACIRDCWAEDPEERPEFSVIRNRLKKM-RGGKTKN---IMDQMME---MMEKYANNLEDIVTE 853
                     .|..:.|.:..:....:..: .|.:|:|   ::.|.::   :.:..|...:.|::.
Mouse   136 ---------EEGLDIRVKIGLAAGHITMLVFGDETRNYFLVIGQAVDDVRLAQNMAQMNDVILSP 191

  Fly   854 RTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGF------------- 905
            ....||:..|    :....:|...|.|::..:.....::|   .:|:..:||
Mouse   192 NCWQLCDRSM----IEIERIPDQRAVKVSFLKPPPTFNFD---EFFTKCMGFMDYYPSGDHKNFL 249

  Fly   906 -TAMSAESTP---LQVVNFLND--LYTVFDRIIRGY-----------------DVYKVETIGDA- 946
             .|...||.|   |.:..::.:  |..:.|:.:|||                 :..|||.||.|
Mouse   250 RLACMLESDPELELSLQKYVMEIILKQIDDKQLRGYLSELRPVTIVFVNLMFKEQDKVEVIGSAI 314

  Fly   947 -----------------------------YMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIA 982
                                         ::.|.|.|   |::...|| :.|||  .||......
Mouse   315 QAACVHITSVLKVFRGQINKVFMFDKGCSFLCVFGFP---GEKAPDEI-THALE--SAVDIFDFC 373

  Fly   983 HRPNETLKLRIGMHTGPVVAGVVGLTM-PRYCLFGDTVNTASRM 1025
            .:.::...:.||:.:|.|..|:||.|: ..|.:.|..||.|:||
Mouse   374 SQVHKIRTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARM 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	16/96 (17%)
		HNOBA	<835..881	CDD:285003	8/48 (17%)
		CYCc	860..1052	CDD:214485	50/233 (21%)
		Guanylate_cyc	887..1074	CDD:278633	46/206 (22%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636	27/155 (17%)
		CHD	292..461	CDD:143636	32/132 (24%)
		COG3899	485..>959	CDD:226415
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900