DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Npr1

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1139	Identity:	410/1139 - (35%)
Similarity:	600/1139 - (52%)	Gaps:	176/1139 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPN------- 66
            ||||...:.....|.:.|||..:..||..........:..|:.:||..|...|:|||.
  Rat    14 LLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL 78

  Fly    67 -----------------VYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQS 114
                             ..:||:|..:.                  |...|| |..|..|.|.:.
  Rat    79 GSSENAAGVCSDTAAPLAAVDLKWEHSP------------------AVFLGP-GCVYSAAPVGRF 124

  Fly   115 R---NIPMISYKCA--------EYRASAIPTFARTEPPDTQVVKSLLALLRYYAW-NKFSILYED 167
            .   .:|:::....        ||   |:.|  ||.|...::...:.||.|...| ::..:||.|
  Rat   125 TAHWRVPLLTAGAPALGIGVKDEY---ALTT--RTGPSHVKLGDFVTALHRRLGWEHQALVLYAD 184

  Fly   168 -------VWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTR 225
                   .:..|..|......:.|:|:|| |.|::.            ...::.:|::....:.|
  Rat   185 RLGDDRPCFFIVEGLYMRVRERLNITVNH-QEFVEG------------DPDHYPKLLRAVRRKGR 236

  Fly   226 IYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREA-----EKYLRRVDQITFMSNC 285
            :.....:.::..:.|.....|||... :|:...:|:...|.:.|     :|...|.|     ...
  Rat   237 VIYICSSPDAFRNLMLLALNAGLTGE-DYVFFHLDVFGQSLKSAQGLVPQKPWERGD-----GQD 295

  Fly   286 HSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYL 350
            .|.....|.|:  ::....|...:|::|.||::..:.| .||..     ||....   :|..|..
  Rat   296 RSARQAFQAAK--IITYKEPDNPEYLEFLKQLKLLADK-KFNFT-----VEDGLK---NIIPASF 349

  Fly   351 YDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEG 415
            :|.:.||..||.:.|.:...|          ::|..:... :.||::..:|| .:|||:.||.:.
  Rat   350 HDGLLLYVQAVTETLAQGGTV----------TDGENITQR-MWNRSFQGVTG-YLKIDRNGDRDT 402

  Fly   416 NFSVLAYKPHKWNNSNNMPCNYH-----MVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPM 475
            :||:....|.  ..:..:..||:     ::.|:      ||..|        ||. |..|.|.|.
  Rat   403 DFSLWDMDPE--TGAFRVVLNYNGTSQELMAVS------EHKLY--------WPL-GYPPPDVPK 450

  Fly   476 CGFANE--LCKKDDTHY-TSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKI-----DP 532
            |||.||  .|.:|  |: |..|.|:|..:.|....:::..||||.::|.|:...||::     .|
  Rat   451 CGFDNEDPACNQD--HFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQP 513

  Fly   533 NEIKGYSGNEIVSSPSKVSLMS-AQSYGSRWTN----QFVTSTGRLRGAVVRIKELKFPRKR-DI 591
            :.::    ..:.|:.|:::|.. ..:|||..|.    |....|...:|.:|.:|.:.  ||| ::
  Rat   514 SSLE----RHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN--RKRIEL 572

  Fly   592 SREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIH 656
            :|:::.|::.:|:::::::..|:||..:|..|.::|:||.:|||.||:|||.|.||.:|..||.:
  Rat   573 TRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTN 637

  Fly   657 DLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRA 721
            |::|||:::||..:..|||||||||||..|::|::||:||...|   :.|....|..:..:||.|
  Rat   638 DIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR---DPEPEQGHTLFAKKLWTA 699

  Fly   722 PELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGED-PFR 780
            |||||   ....|||.||||:|.||:.||..|.|.|  ..::..||||::.|    .:||. |||
  Rat   700 PELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERV----TRGEQPPFR 760

  Fly   781 PEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYAN 845
            |.    ::.:|..:.:...::.||||||:|||.|..||..|:|.....:.||:|.::..||:|||
  Rat   761 PS----MDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYAN 821

  Fly   846 NLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSA 910
            |||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.|||||||||||||:||
  Rat   822 NLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSA 886

  Fly   911 ESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHA 975
            ||||:|||..||||||.||.:|..:|||||||||||||||||||::||..||.|:|.|||.||.|
  Rat   887 ESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDA 951

  Fly   976 VKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKC 1040
            |:..||.|||.|.|:||||:|||||.||||||.|||||||||||||||||||||||||||:|::.
  Rat   952 VRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET 1016

  Fly  1041 KLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            |..|::. .|:..|.||.|.|||||.|.|:||.|
  Rat  1017 KAVLEEF-DGFELELRGDVEMKGKGKVRTYWLLG 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	97/471 (21%)
		ANF_receptor	48..412	CDD:279440	84/411 (20%)
		PK_GC-A_B	543..827	CDD:270944	115/295 (39%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	133/191 (70%)
		Guanylate_cyc	887..1074	CDD:278633	131/186 (70%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	99/488 (20%)
		ANF_receptor	50..410	CDD:279440	88/425 (21%)
		PK_GC-A_B	530..803	CDD:270944	112/285 (39%)
		TyrKc	543..797	CDD:197581	106/266 (40%)
		HNOBA	<812..857	CDD:285003	25/44 (57%)
		CYCc	836..1025	CDD:214485	132/189 (70%)
		Guanylate_cyc	863..1049	CDD:278633	131/186 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710