DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1201	Identity:	378/1201 - (31%)
Similarity:	580/1201 - (48%)	Gaps:	231/1201 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NLLLLLSVAVRDCSNHRTVLTVGYLTA--LTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYL 69
            :|:|.|.|.:.........||||:...  ::.....::   :...|.:|:|::|.:| :.|.
  Rat    30 SLVLTLFVVMLMTCLEAAKLTVGFHAPWNISHPFSVQR---LGAGLQIAVDKLNSEP-VGPG--- 87

  Fly    70 DLRWNDTKGDTVLATKA-----ITEMICDGIATIFGPEGPCYVEAI--VSQSRNIPMISYK---- 123
            :|.|..|..:.....|.     |.::..:.|:.:.||..|...|.|  ::...:||:..:.
  Rat    88 NLSWEFTYTNATCNAKESLAAFIDQVQREHISVLIGPACPEAAEVIGLLASEWDIPLFDFVGQMT 152

  Fly   124 -------CAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL-----------YEDVWS 170
                   |        .|.....||..::...|...|:|..|....:.           ..::|.
  Rat   153 ALEDHFWC--------DTCVTLVPPKQEIGTVLRESLQYLGWEYIGVFGGSSAGSSWGEVNELWK 209

  Fly   171 PVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANS 235
            .|.|.|:...|            |..||:......|..:.|     :::..:..|:.:.:.::..
  Rat   210 AVEDELQLHFT------------ITARVRYSSGHSDLLQEG-----LRSMSSVARVIILICSSED 257

  Fly   236 LVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLV 300
            ....:.:.|..||.:| |::.:.:..:   |....|.:...|::|         .|.::..|:.:
  Rat   258 AKHILQAAEDLGLNSR-EFVFLLLQQL---EDSFWKEVLAEDKVT---------RFPKVYESVFL 309

  Fly   301 VASTPPT------KDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAW 359
            :|  |.|      .|  .|.|||.:...:|||...|       :....:|.|:|||:|::.|||.
  Rat   310 IA--PSTYGGSAGDD--DFRKQVYQRLRRPPFQSSI-------SSEDQVSPYSAYLHDALLLYAQ 363

  Fly   360 AVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNR-TYMSITGSKIKIDQYGDSEGNFSVLAYK 423
            .|::|::.|          :...:|.::|.|:..:: |...||| .:.:|..|....::||.|.:
  Rat   364 TVEEMMKAE----------KDFRDGRQLISTLRADQVTLQGITG-PVLLDAQGKRHMDYSVYALQ 417

  Fly   424 PHKWNNSNNMPCNYHMVPVAYFHQGE-------------------EHPEYKLINGSIDWPSGGEK 469
             ...|.|..:|         :.|...                   .|||||
  Rat   418 -KSGNGSRFLP---------FLHYDSFQKVIRPWRDDLNASGPHGSHPEYK-------------- 458

  Fly   470 PADEPMCGFANELCK-KDDT--HYTSTVAAVVLGV-LLFCSGVITMSIYRKWKIELEIEG----L 526
                |.|||..:||: |..|  ..|::|.||:..| ||..:....::....|::..:::.    .
  Rat   459 ----PDCGFHEDLCRTKPPTGAGMTASVTAVIPTVTLLVVASAAAITGLMLWRLRGKVQNHPGDT 519

  Fly   527 LWKID-------PNEIKGYSGNEI----VSSPSKVSLMSAQSYGSRWTNQ----FVTSTGRLRG- 575
            .|:|.       |.....:.|..:    ||:.|.|.: ||.......|:|    |....|..:|
  Rat   520 WWQIHYDSITLLPQHKPSHRGTPMSRCNVSNASTVKI-SADCGSFAKTHQDEELFYAPVGLYQGN 583

  Fly   576 ----------AVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYC 630
                      |..|||:          ..:::|:.|:.||:|:||..|.|...||..|.:||..|
  Rat   584 HVALCYIGEEAEARIKK----------PTVLREVWLMCELKHENIVPFFGVCTEPPNICIVTQCC 638

  Fly   631 AKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFG 695
            .||||.|::.|.|.::|.:|..|.::|::.||:::|.|.|..|||||.|||:|.|...|::..||
  Rat   639 KKGSLKDVLRNSDHEMDWIFKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFG 703

  Fly   696 LHELRQCAE----NESIGEHQHYRNQLWRAPELLRNH---IHGSQKGDVYAFAIIMYEIFSRK-- 751
            |.|.:..:.    |:...:|...   .|.||||||..   ..|:.:||||:|||::.::..::
  Rat   704 LWEFKHGSTCRIYNQEATDHSEL---YWTAPELLRLRELPWSGTPQGDVYSFAILLRDLIHQQAH 765

  Fly   752 GPFGQINFEPKEIVDYVK--KLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEF 814
            |||..:...|:||:..:|  :.|:    |.||   |::| :...:.::|.:|.||||.||:||.|
  Rat   766 GPFEDLEAAPEEIISCIKDSRAPV----PLRP---SLLE-DKGDERIVALVRACWAESPEQRPAF 822

  Fly   815 SVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAE 879
            ..|:..|::.......:|:|.||..:|.||::||::|.|||..|..||.|.|.||..|||..|.|
  Rat   823 PSIKKTLREASPRGRVSILDSMMGKLEMYASHLEEVVEERTCQLVAEKRKVEKLLSTMLPSFVGE 887

  Fly   880 KLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIG 944
            :|..|:.|||..::.|||:||||||||.:.:.|:|||||..|||||::||..|:.:|||||||||
  Rat   888 QLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVYKVETIG 952

  Fly   945 DAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTM 1009
            |||||.|||||:||.:||.|||:|:|.||......:|.|.|.|.||||||:|||||||||||:||
  Rat   953 DAYMVASGLPIRNGAQHADEIATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITM 1017

  Fly  1010 PRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            |||||||||||.||||||:...|:||:|.....|| .:.|||..:|||.:::||||:..|:||||
  Rat  1018 PRYCLFGDTVNMASRMESSSLPLRIHVSQSTARAL-LVAGGYHLQKRGTISVKGKGEQTTFWLTG 1081

  Fly  1075 ANENAIQKKLVDMMDMPPPLFSRPR-KSPKL 1104
            .:..|:          |.|.|:... |.|::
  Rat  1082 KDGFAV----------PLPEFTEEEAKVPEI 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	92/456 (20%)
		ANF_receptor	48..412	CDD:279440	81/399 (20%)
		PK_GC-A_B	543..827	CDD:270944	104/313 (33%)
		HNOBA	<835..881	CDD:285003	23/45 (51%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	117/186 (63%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	92/465 (20%)
		ANF_receptor	66..417	CDD:279440	85/417 (20%)
		PK_GC	558..832	CDD:270894	99/294 (34%)
		CYCc	868..1058	CDD:214485	118/190 (62%)
		Guanylate_cyc	895..1081	CDD:278633	117/186 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.770