DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Gucy2f

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001007577.1	Gene:	Gucy2f / 245650	MGIID:	105119	Length:	1108	Species:	Mus musculus

Alignment Length:	1206	Identity:	377/1206 - (31%)
Similarity:	557/1206 - (46%)	Gaps:	250/1206 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPFN-LLLLLSVAVRDCSNH----RTVLTVGYLTALTGDLKTRQGL----AISG----------- 48
            |||: ||...:::.|....|    ...|....|.||...|:..|.|    .:.|
Mouse     6 WPFSRLLSWFAISSRLSGQHGLPSSKFLRCLCLLALLPLLRWGQALPYKIGVIGPWTCDPFFSKA 70

  Fly    49 ----ALTMALDEVNKDPNLLPNV---YLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCY 106
                |..:|::.:::|.....:.   |:.|. .|.:....||:....:.:..|..   ||..|.:
Mouse    71 LPEVAAALAIERISRDKTFDRSYSFEYVILN-EDCQTSKALASFISHQQMASGFV---GPANPGF 131

  Fly   107 VEA--IVSQSRNIPMISYKCAEYRAS---AIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY- 165
            .||  ::..|.:..:.|:.|..:...   :.|||:||.|...:|   |:.:::|:.|....::.
Mouse   132 CEAASLLGTSWDKGIFSWACVNHELDNKHSFPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISS 193

  Fly   166 -EDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVF 229
             ||:|...|                      |||.
Mouse   194 DEDIWMHTA----------------------NRVS------------------------------ 206

  Fly   230 LGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAE------KYLRRVDQITFMSNC-HS 287
                       |::.:.||         .|.:::.|.|:::      :.:|:.|:|..:..| ||
Mouse   207 -----------SALRSQGL---------PVGVVLTSGRDSQSIQKALQQIRQADRIRIIIMCMHS 251

  Fly   288 T-------ENFNQMARSLLVVASTPPTKDYIQFTKQVQKYS---SKPPFNL--EIPRL------- 333
            .       .:|.::|..|.:...|     |:.....|..||   ...|:.:  ..|:|
Mouse   252 ALIGGETQTHFLELAHDLKMTDGT-----YVFVPYDVLLYSLPYKHSPYQVLRNNPKLREAYDAV 311

  Fly   334 ---FVESNFSKFISIYA---------------------AYLYDSVKLYAWAVDKMLREETRVLTD 374
               .|||:...|...||                     ..:|:|:...|.|::..:::
Mouse   312 LTITVESHEKTFYEAYAEAAARGEIPEKPDSNQVSPLFGTIYNSIYFIAQAMNNAMKK------- 369

  Fly   375 DVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNY 437
                    ||.....:::::...|...|  ..||.|..|:....:.:|.....:|.....
Mouse   370 --------NGRASAASLVQHSRNMQFYGFNQLIKTDSNGNGISEYVILDTNGKEWELRGT----- 421

  Fly   438 HMVPVAYFHQGEEHPEYKLINGS-IDWPSGGEKPADEPMCGFA-NELCKKD-DTHYTSTVAAVVL 499
                    :..:...|.....|: |.:| ||...:.:..|.|| .::|:.. |......|...:|
Mouse   422 --------YTVDMETELLRFRGTPIHFP-GGRPTSADAKCWFAERKICQGGIDPALAMMVCFALL 477

  Fly   500 GVLLFCSGVITMSIYRKWKIELEIEG----LLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGS 560
            ..||..:|.......|..||:| |:|    ||...|...|..:.|:: ..|.:.||........|
Mouse   478 IALLSINGFAYFIRRRINKIQL-IKGPNRILLTLEDVTFINPHFGSK-RGSRASVSFQIISEVQS 540

  Fly   561 RWTNQFVTSTGRLRGAVVRIKEL-----------KFPRK-----RDISREIMKEMRLLRELRHDN 609
            ..:.:...|:|.|..|......:           |||..     :.|.........::::|||:|
Mouse   541 GRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHEN 605

  Fly   610 INSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHG 674
            :|..:|...:.....:|:::|::.||.||:.|:|:|||.:|.:||:.||||||.|:|:.:.: ||
Mouse   606 VNPLLGFFYDSGMFAIVSEFCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKYLHHREFI-HG 669

  Fly   675 NLKSSNCVVTSRWMLQVTDFGLH---ELRQCAENESIGEHQHYRNQLWRAPELLR--NHIH-GSQ 733
            .|||.||||..|::|:|||:|.:   |:.:.:|.|...|     ..||.||||||  ..|. ||.
Mouse   670 RLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEEPSEE-----ELLWTAPELLRAPGGIRLGSF 729

  Fly   734 KGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLA 798
            .||||:|||||.|:..|..||..::...|||:|.:|..|        |....::..|..|...|.
Mouse   730 AGDVYSFAIIMQEVMVRGAPFCMMDLPAKEIIDRLKMPP--------PVYRPVVSPEYAPAECLQ 786

  Fly   799 CIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKM 863
            .::.||||..|:||.|..|.|:.|....||..||:|.|:.|:|:|::||||::.|||..|..||.
Mouse   787 LMKQCWAEASEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQ 851

  Fly   864 KTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVF 928
            |||.||.:|||.||||.|..|..|||..:||||:|||||||||.:||.|.|::||:.||||||:|
Mouse   852 KTEKLLTQMLPLSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLF 916

  Fly   929 DRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRI 993
            |.||..:||||||||||||||.||||.:||.|||.|||:|:|::|.:|...::.|.|...:::||
Mouse   917 DAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRI 981

  Fly   994 GMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGL 1058
            |:|:||||||||||||||||||||||||||||||.|...:||:|......|..|..||..|.||.
Mouse   982 GLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEVELRGR 1046

  Fly  1059 VNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPL 1094
            ..:||||...|:||.|      :|.....:.:|||:
Mouse  1047 TELKGKGTEETFWLVG------KKGFTKPLPVPPPV 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	85/499 (17%)
		ANF_receptor	48..412	CDD:279440	75/440 (17%)
		PK_GC-A_B	543..827	CDD:270944	104/305 (34%)
		HNOBA	<835..881	CDD:285003	26/45 (58%)
		CYCc	860..1052	CDD:214485	121/191 (63%)
		Guanylate_cyc	887..1074	CDD:278633	116/186 (62%)
Gucy2f	NP_001007577.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	79/492 (16%)
		PKc_like	545..815	CDD:419665	100/283 (35%)
		HNOBA	<824..869	CDD:400168	26/44 (59%)
		CYCc	848..1040	CDD:214485	121/191 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810