DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc76C and PHLPP1

DIOPT Version :9

Sequence 1:NP_001163473.1 Gene:Gyc76C / 8674026 FlyBaseID:FBgn0266136 Length:1525 Species:Drosophila melanogaster
Sequence 2:NP_919431.2 Gene:PHLPP1 / 23239 HGNCID:20610 Length:1717 Species:Homo sapiens


Alignment Length:1118 Identity:196/1118 - (17%)
Similarity:357/1118 - (31%) Gaps:418/1118 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   540 GNEIVSSPSKVSLMSAQSYGSRWTNQF---------VTSTGRL--RGAVVRIKELKFPRKRDISR 593
            ||.:.|.|:::..|...||.....|:|         :|:..:|  .|..|....|:..||....:
Human   746 GNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIK 810

  Fly   594 EIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDL 658
            .:...:.::|:|..|.:                 |:....:..|:.:|   ||.||  .::|.:.
Human   811 HVDLRLNVIRKLIADEV-----------------DFLQHVTQLDLRDN---KLGDL--DAMIFNN 853

  Fly   659 IKGMIYIHNSQLV------YHGNLK----SSNCVV---------------TSR--------WM-- 688
            |: :::...:|||      |.  ||    |||.:|               .||        |:  
Human   854 IE-VLHCERNQLVTLDICGYF--LKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCE 915

  Fly   689 ---LQVTDFGLHELRQ------CAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIM 744
               |:|.|.|.:::.:      |  |.|:.:.....|||.|.||.|..               ..
Human   916 SRKLEVLDIGHNQICELPARLFC--NSSLRKLLAGHNQLARLPERLER---------------TS 963

  Fly   745 YEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVL-----ACIRDCW 804
            .|:         ::.:..::::....|.:|. |..|....|..:.||.|...|     :.:::.:
Human   964 VEV---------LDVQHNQLLELPPNLLMKA-DSLRFLNASANKLESLPPATLSEETNSILQELY 1018

  Fly   805 AEDPE----------ERPEFSVIR---NRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTR 856
            ..:..          ..|...::.   |||:.....|...:  :.:|.::...|.|:.|.|  |.
Human  1019 LTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKL--EELEEIDLSGNKLKAIPT--TI 1079

  Fly   857 LLCE----------------EKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGF 905
            :.|.                |.|:..::....|..:...::|:.:.:.|...:|      |:.|.
Human  1080 MNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQEL------DLTGN 1138

  Fly   906 TAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVE--TIGDA----------YMVVSGLPIK-- 956
            ..:..:...|:::|.:.              .:|::  :.|||          |...||:..|  
Human  1139 PRLVLDHKTLELLNNIR--------------CFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLC 1189

  Fly   957 --------------------NGDRH---------------AGEIASMALELLHAVKQHRIAHRPN 986
                                :|||:               |.|:.....|..:.|....:..|..
Human  1190 VAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKL 1254

  Fly   987 ETLKLRIG-------MHTGPVVAGVVGLTMPRYCLFGDTVNTASRMES-------NGEALKIHIS 1037
            .|...::|       :...||..|            |....|::.:..       ||:.|.:..|
Human  1255 GTAGQKLGGAAVLCHIKHDPVDPG------------GSFTLTSANVGKCQTVLCRNGKPLPLSRS 1307

  Fly  1038 --NKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPR- 1099
              ..|:..|.:     |.:.:.::...||       :.|..|:.   :::....:.|.:..||. 
Human  1308 YIMSCEEELKR-----IKQHKAIITEDGK-------VNGVTEST---RILGYTFLHPSVVPRPHV 1357

  Fly  1100 KSPKLNPD---------------SRQPSIQAMHFCGTGSRRQSTVPRAM---------------- 1133
            :|..|.|.               |.:.:::|:.          .||.|:                
Human  1358 QSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVR----------NVPDALAAAKKLCTLAQSYGCH 1412

  Fly  1134 DGESTYSLQGSVRES---------------------PRMVSKRDRDRERPPINGLGAGHFVGGAL 1177
            |..|...:|.||.|.                     |..|:...:||   |.:|||......|..
Human  1413 DSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSVNMVIKDR---PSDGLGVPSSSSGMA 1474

  Fly  1178 LE-SAQASLSTLNHSETNETNCDMDGGSGGVSGSGSGLVRQPNALHKPLAMVR--PHRIISAAQL 1239
            .| |::.|.|.:: ||...|..| :...|.:|.:......:...:..|:.:..  ..::.||...
Human  1475 SEISSELSTSEMS-SEVGSTASD-EPPPGALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFS 1537

  Fly  1240 PQLGDNDDDSADTLLRESRSLDPMPMQQLRKRHDRVKLPPSKLSKNNSRSLDTGVSLISGNPNGE 1304
            ....||..||.|                        :.|...:..|.|| ::..|         :
Human  1538 SAFSDNGLDSDD------------------------EEPIEGVFTNGSR-VEVEV---------D 1568

  Fly  1305 VHSS---QLDLDNEMTANPVDATD------GYDDELGLLMRHDNGQLPALRYSGSFPNAQISIVP 1360
            :|.|   :.:....:...|.:|:|      ..:||.||..:.|                      
Human  1569 IHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKAD---------------------- 1611

  Fly  1361 TGRSAGGGGGGREGGGSNCAKHLNNNCNGGVNVEDDLESPLLQRQASLS------------VPPE 1413
              .||.|..|.|...||...:..::|.     :|...::||.:.....:            :|||
Human  1612 --FSAVGTIGRRRANGSVAPQERSHNV-----IEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPE 1669

  Fly  1414 ------EMLAHNK 1420
                  |::.|::
Human  1670 LEEEVKEIMKHHQ 1682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc76CNP_001163473.1 PBP1_Speract_GC_like 26..445 CDD:107365
ANF_receptor 48..412 CDD:279440
PK_GC-A_B 543..827 CDD:270944 67/356 (19%)
HNOBA <835..881 CDD:285003 10/61 (16%)
CYCc 860..1052 CDD:214485 39/272 (14%)
Guanylate_cyc 887..1074 CDD:278633 38/251 (15%)
PHLPP1NP_919431.2 leucine-rich repeat 1107..1129 CDD:275380 2/21 (10%)
PP2Cc 1168..1420 CDD:214625 43/288 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1458..1510 17/56 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1673..1717 2/10 (20%)
PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269|PubMed:21804599 1715..1717
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 41..118
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..156
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 252..470
PH_PHLPP-like 535..631 CDD:270131
PH 555..636 CDD:278594
LRR_RI 625..929 CDD:238064 45/207 (22%)
LRR_8 638..703 CDD:290566
LRR 1 638..659
leucine-rich repeat 641..661 CDD:275380
LRR 2 661..682
leucine-rich repeat 662..692 CDD:275380
LRR 3 692..712
leucine-rich repeat 693..738 CDD:275380
LRR_8 714..770 CDD:290566 7/23 (30%)
LRR 4 715..736
LRR 5 738..760 4/13 (31%)
leucine-rich repeat 739..761 CDD:275380 5/14 (36%)
LRR 6 761..783 4/21 (19%)
leucine-rich repeat 762..784 CDD:275380 4/21 (19%)
LRR 7 784..804 4/19 (21%)
leucine-rich repeat 785..808 CDD:275380 6/22 (27%)
LRR 8 808..831 4/39 (10%)
leucine-rich repeat 810..832 CDD:275380 4/38 (11%)
LRR_RI 814..1074 CDD:238064 57/313 (18%)
LRR 9 832..853 7/25 (28%)
leucine-rich repeat 833..853 CDD:275380 7/24 (29%)
leucine-rich repeat 854..895 CDD:275380 11/43 (26%)
LRR 10 873..894 6/22 (27%)
LRR 11 895..916 3/20 (15%)
leucine-rich repeat 896..918 CDD:275380 3/21 (14%)
LRR 12 918..939 5/22 (23%)
leucine-rich repeat 919..941 CDD:275380 6/23 (26%)
LRR 13 941..962 8/35 (23%)
leucine-rich repeat 942..963 CDD:275380 7/35 (20%)
LRR_8 962..1024 CDD:290566 10/71 (14%)
LRR 14 963..984 2/29 (7%)
leucine-rich repeat 964..987 CDD:275380 3/32 (9%)
LRR 15 987..1008 6/20 (30%)
leucine-rich repeat 988..1011 CDD:275380 6/22 (27%)
LRR 16 1013..1033 0/19 (0%)
LRR_8 1014..1072 CDD:290566 7/59 (12%)
leucine-rich repeat 1014..1037 CDD:275380 0/22 (0%)
LRR 17 1037..1058 4/20 (20%)
leucine-rich repeat 1038..1061 CDD:275380 4/24 (17%)
LRR 18 1061..1082 6/22 (27%)
Interaction with SLC9A3R1. /evidence=ECO:0000269|PubMed:21804599 1076..1205 21/150 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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