DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc76C and PHLPP2

DIOPT Version :9

Sequence 1:NP_001163473.1 Gene:Gyc76C / 8674026 FlyBaseID:FBgn0266136 Length:1525 Species:Drosophila melanogaster
Sequence 2:NP_055835.2 Gene:PHLPP2 / 23035 HGNCID:29149 Length:1323 Species:Homo sapiens


Alignment Length:728 Identity:147/728 - (20%)
Similarity:249/728 - (34%) Gaps:225/728 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   760 EPKE-----IVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFS-VIR 818
            ||.|     :.||:.:|..  :||.|     |.|..:.||  |.|:...:.|.|....... ::.
Human    98 EPTERPLQIVYDYLSRLGF--DDPVR-----IQEEATNPD--LGCMIRFYGEKPCHMDRLDRILL 153

  Fly   819 NRLKKMRGGKTKNIMDQMMEMMEKYANNL-------------EDIVTERTRLLCEEKMKTEDLLH 870
            :.:..:|.|||:         :.|:|..|             :|..|.:..:|.....|.|::..
Human   154 SGIYNVRKGKTQ---------LHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKR 209

  Fly   871 RMLPQSVAEKLTMGQGVEPVSYDLVTIY------FSDIVG-------FTAMSAESTP-----LQV 917
            |....:.:......|... ||::.:..|      .|.:|.       .:..|.|..|     .|.
Human   210 RQYSLAFSSAGAQAQTYH-VSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQD 273

  Fly   918 VNFLNDLYTVFDRIIR--GYD-VYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQH 979
            :.:|| |...|.::.|  |.| :||       :..:.||.:.:  ...|....:..|:       
Human   274 ITYLN-LRHNFMQLERPGGLDTLYK-------FSQLKGLNLSH--NKLGLFPILLCEI------- 321

  Fly   980 RIAHRPNETL-KLRI---GMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEAL-------- 1032
                   .|| :|.:   |.|..|...|.: |.:...||.|:.:.|......|.:.|        
Human   322 -------STLTELNLSCNGFHDLPSQIGNL-LNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFN 378

  Fly  1033 ----------------KIHISNKCKLALDKLGGGYITEKRGL--VNMKGKGDVVTWWLTGANENA 1079
                            ::.::..|   |:.|..|.:.....:  |:::     :....|...||.
Human   379 NFSQIPEVYEKLTMLDRVVMAGNC---LEVLNLGVLNRMNHIKHVDLR-----MNHLKTMVIENL 435

  Fly  1080 IQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGS 1144
            ...|.:..:|:      |..:...|:..| ..|::.:| ||....|:.|:       |.:||:..
Human   436 EGNKHITHVDL------RDNRLTDLDLSS-LCSLEQLH-CGRNQLRELTL-------SGFSLRTL 485

  Fly  1145 VRESPRMVSKRDRDRERPPINGLGAGHFVGGALLESAQASLSTLNHSETNETNCDMDGGSGGVSG 1209
            ...|.|:.                       |:......||.|......|...|..|....... 
Human   486 YASSNRLT-----------------------AVNVYPVPSLLTFLDLSRNLLECVPDWACEAKK- 526

  Fly  1210 SGSGLVRQPNALHKPLAMVRPHRIISAAQLPQ--LGDNDDDSADTLLRESRSLDPMPMQQLRKRH 1272
                 :...:..:..|..| |.||:|:..|.:  ||.|...:..||      ::.:|::.|..:|
Human   527 -----IEVLDVSYNLLTEV-PVRILSSLSLRKLMLGHNHVQNLPTL------VEHIPLEVLDLQH 579

  Fly  1273 DRV-KLPPSKLSKN-NSRSLDTGVSLISGNPN---GEVHSSQLDL----DNEMTANPVDATDGYD 1328
            :.: :||.:..||. |.|.|:...:.:...|:   ||...|.|.|    :|.:|...:....|: 
Human   580 NALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGH- 643

  Fly  1329 DELGLLMRH-DNGQL---PA-----------LRYSGSFPNAQISIVPTGRSAGGGGGGREGGGSN 1378
              |.|.:.| .|.||   ||           |..||:    ::..:||..             :|
Human   644 --LHLRILHLANNQLQTFPASKLNKLEQLEELNLSGN----KLKTIPTTI-------------AN 689

  Fly  1379 CAK------HLNN 1385
            |.:      |.||
Human   690 CKRLHTLVAHSNN 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc76CNP_001163473.1 PBP1_Speract_GC_like 26..445 CDD:107365
ANF_receptor 48..412 CDD:279440
PK_GC-A_B 543..827 CDD:270944 18/72 (25%)
HNOBA <835..881 CDD:285003 9/58 (16%)
CYCc 860..1052 CDD:214485 44/240 (18%)
Guanylate_cyc 887..1074 CDD:278633 41/237 (17%)
PHLPP2NP_055835.2 PH_PHLPP-like 149..243 CDD:270131 17/103 (17%)
LRR 1 250..271 3/20 (15%)
leucine-rich repeat 253..273 CDD:275380 3/19 (16%)
LRR 2 273..296 7/23 (30%)
leucine-rich repeat 274..300 CDD:275380 9/33 (27%)
LRR 3 300..321 3/22 (14%)
leucine-rich repeat 301..323 CDD:275380 4/37 (11%)
LRR_RI 313..606 CDD:238064 68/366 (19%)
LRR_8 322..380 CDD:290566 14/58 (24%)
LRR 4 323..344 7/20 (35%)
leucine-rich repeat 324..346 CDD:275380 6/22 (27%)
LRR 5 346..368 5/21 (24%)
leucine-rich repeat 347..369 CDD:275380 5/21 (24%)
LRR 6 369..390 1/20 (5%)
leucine-rich repeat 370..416 CDD:275380 5/48 (10%)
LRR 7 392..412 4/22 (18%)
LRR 8 416..439 4/27 (15%)
leucine-rich repeat 418..440 CDD:275380 4/26 (15%)
LRR 9 440..460 4/26 (15%)
leucine-rich repeat 442..461 CDD:275380 4/25 (16%)
LRR 10 461..480 7/26 (27%)
leucine-rich repeat 462..481 CDD:275380 6/26 (23%)
LRR 11 481..502 5/43 (12%)
leucine-rich repeat 482..503 CDD:275380 4/43 (9%)
LRR 12 503..524 5/20 (25%)
leucine-rich repeat 504..526 CDD:275380 4/21 (19%)
LRR 13 526..547 5/27 (19%)
leucine-rich repeat 527..549 CDD:275380 6/22 (27%)
LRR_8 549..606 CDD:290566 16/62 (26%)
LRR 14 549..570 6/26 (23%)
leucine-rich repeat 550..565 CDD:275380 4/14 (29%)
LRR 15 571..592 5/20 (25%)
leucine-rich repeat 572..595 CDD:275380 6/22 (27%)
LRR 16 595..616 4/20 (20%)
leucine-rich repeat 596..645 CDD:275380 11/51 (22%)
LRR 17 621..644 5/25 (20%)
LRR_8 645..703 CDD:290566 17/75 (23%)
LRR_4 645..685 CDD:289563 10/43 (23%)
LRR 18 645..666 7/20 (35%)
leucine-rich repeat 646..669 CDD:275380 7/22 (32%)
LRR 19 669..690 5/37 (14%)
leucine-rich repeat 670..692 CDD:275380 7/38 (18%)
LRR 20 692..713 3/11 (27%)
leucine-rich repeat 693..714 CDD:275380 3/10 (30%)
LRR 21 714..735
leucine-rich repeat 715..734 CDD:275380
LRR 22 737..758
leucine-rich repeat 738..764 CDD:275380
PP2Cc 784..1033 CDD:238083
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1060..1157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1285..1323
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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