DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and ADCY4

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001185497.1	Gene:	ADCY4 / 196883	HGNCID:	235	Length:	1077	Species:	Homo sapiens

Alignment Length:	268	Identity:	82/268 - (30%)
Similarity:	128/268 - (47%)	Gaps:	51/268 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   858 LCEEKMKTED-------LLHRMLPQSVAEKLTMGQG-----VEPVSYDLVTIYFSDIVGFTAMSA 910
            |.:|:.:||.       ||..:||..||.:. :||.     :...||:.|.:.|:.:..|....:
Human   824 LRQEREETETMENLTRLLLENVLPAHVAPQF-IGQNRRNEDLYHQSYECVCVLFASVPDFKEFYS 887

  Fly   911 EST----PLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDAYMVVSGLPIKNGD--------- 959
            ||.    .|:.:..||::...||.::   :...|.|::|||..||..:||...:|.
Human   888 ESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERS 952

  Fly   960 -RHAGEIASMALEL---LHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVN 1020
             .|.|.:...|:.|   |..:.:|..     ...:||:|::.|||||||:|...|:|.::|:|||
Human   953 CSHLGTMVEFAVALGSKLDVINKHSF-----NNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVN 1012

  Fly  1021 TASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLV 1085
            .||||||.|...||.::.:...||..|  ||....||::.:||||.:.|::|.           .
Human  1013 VASRMESTGVLGKIQVTEETAWALQSL--GYTCYSRGVIKVKGKGQLCTYFLN-----------T 1064

  Fly  1086 DMMDMPPP 1093
            |:....||
Human  1065 DLTRTGPP 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944
		HNOBA	<835..881	CDD:285003	10/29 (34%)
		CYCc	860..1052	CDD:214485	69/223 (31%)
		Guanylate_cyc	887..1074	CDD:278633	67/206 (33%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831
		CYCc	219..422	CDD:214485
		Guanylate_cyc	264..418	CDD:278633
		DUF1053	479..583	CDD:283888
		CYCc	827..1042	CDD:214485	69/222 (31%)
		Guanylate_cyc	864..1063	CDD:278633	66/205 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810