DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and gcy-36

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_510557.3	Gene:	gcy-36 / 191657	WormBaseID:	WBGene00001556	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	105/245 - (42%)
Similarity:	142/245 - (57%)	Gaps:	18/245 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   838 EMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDI 902
            |.:|..|.:||           .||.||:.||..|||.|||::|..|..||...|:..|:.|:|:
Worm   403 EQLENMAKDLE-----------VEKGKTDALLREMLPPSVAQQLKQGLSVEAREYEEATVMFTDV 456

  Fly   903 VGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIAS 967
            ..|..:....||..:|:.||:|:|.|||:|.....|||||:||:||.|.|:| ...|.|...|..
Worm   457 PTFQQIVPLCTPKDIVHLLNELFTKFDRLIGIQKAYKVETVGDSYMSVGGIP-DLVDDHCEVICH 520

  Fly   968 MALELLHAVKQHRIAHRP--NETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGE 1030
            :||.:   |.:.|....|  |..|.:|.|:|:|||||||||..|||||||||||||:|||||:..
Worm   521 LALGM---VMEARTVCDPITNTPLHIRAGIHSGPVVAGVVGAKMPRYCLFGDTVNTSSRMESHSP 582

  Fly  1031 ALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAI 1080
            ..:||.|...|...:.. |.:..|.||.|.:||||::.|::|..:.:.:|
Worm   583 IGRIHCSENAKKCAEST-GRFEFEPRGRVQIKGKGEMNTYFLLRSFKRSI 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944
		HNOBA	<835..881	CDD:285003	17/42 (40%)
		CYCc	860..1052	CDD:214485	89/193 (46%)
		Guanylate_cyc	887..1074	CDD:278633	85/188 (45%)
gcy-36	NP_510557.3	HNOB	3..167	CDD:285002
		HNOBA	217..435	CDD:285003	17/42 (40%)
		CYCc	415..604	CDD:214485	89/193 (46%)
		Guanylate_cyc	441..624	CDD:278633	84/187 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810