DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and gcy-34

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	179/696 - (25%)
Similarity:	289/696 - (41%)	Gaps:	180/696 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 NELCKKDDTHYTSTVAAVVLGVL------LFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGY 538
            |......||:......::||.|.      ::...:||.|:...|      :.|:..:.|| :||:
Worm    40 NHYYSDTDTYVLVDSVSIVLKVTKDQIWEMYGGFLITYSMEIGW------DELVRSMSPN-LKGF 97

  Fly   539 SGN---------EIVSSPSKVSLMSAQSY-------GSRWTNQFVTSTGR------LRGAVVRIK 581
            ..|         .:|...:    :...|:       |:...:.|   |||      ::|.|..:.
Worm    98 LDNLDSLHYFIDHVVYKAN----LRGPSFRCEENPDGTLMLHYF---TGRPGLYHIVKGVVKEVA 155

  Fly   582 ELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLV---------TDYCAKGSLYD 637
            :|.|  ..|||  ::.:.|..|.:..:|     |..||...|.|:         :|.....:|..
Worm   156 KLVF--NLDIS--LVVQGRTQRSVHMNN-----GERVEEHVIFLIKNVEEPRRDSDTSTTSALTS 211

  Fly   638 IIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQC 702
            :..:         ...:|.|.:|..:...:..|.||..|..| |                .|.||
Worm   212 VEPD---------FGEIIDDNLKVSLQDFSRALPYHFVLDES-C----------------RLVQC 250

  Fly   703 AENESIGEHQHYRNQLWR-APELLRNHIHGSQKGDVYAFAIIMYEIFSRKGP--FGQI-NFEPKE 763
            .:.    .:.|..|:|.: ...:||                 ::||...:.|  |..| ||....
Worm   251 GDE----LYNHIPNELLQPGTPILR-----------------IFEINRPQIPLDFENICNFINAV 294

  Fly   764 IVDYVKKLPLK-------GEDPFRPEVESI-IEAES---------------------------CP 793
            .|..||..||:       .::....|||:: .|.||                           |.
Worm   295 FVLQVKTSPLRKKHMNAMTKEEREQEVEAMEEEVESNELTQGCHLKLKGQMMMLSTKKHIIYLCS 359

  Fly   794 DYVLACIRDCWAEDPEERPEFSVIRNRLKKM-RGGKTKNI-------MDQMMEMMEKYANNLEDI 850
            .||.:.         .|..:|.:   ||..| ....|:::       :..:...::..||| |.:
Worm   360 PYVTSI---------NELMQFGM---RLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANN-EQL 411

  Fly   851 VTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPL 915
            .| .|..|..|:.||:.:|..|||:.:|::|..|:.:||..|: .|:.|.|:..|..:.....|.
Worm   412 ET-MTHELEVERQKTDSILKDMLPRKIAKQLLSGEHLEPCEYE-ATVMFCDLPAFQQIIPVCQPK 474

  Fly   916 QVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHR 980
            .:|..||:::...|||:....||||||:.|:||.|||:|....: ||..:..:||.::...:.
Worm   475 NIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIPDYTSE-HAENMCHVALGMMWEARS-- 536

  Fly   981 IAHRPNET-LKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISN-KCKLA 1043
            :....|:| ..||||:|:|.::|||||..||||||||:||..||:|||.|.|.||..|: ....|
Worm   537 VMDPVNKTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKA 601

  Fly  1044 LDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMD 1089
            ::.  |.:....||.:|:||:|||.|::|.    .:::|.:.::.|
Worm   602 MET--GRFEFSPRGRINVKGRGDVETYFLM----RSLKKSIWEITD 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	67/345 (19%)
		HNOBA	<835..881	CDD:285003	15/45 (33%)
		CYCc	860..1052	CDD:214485	76/193 (39%)
		Guanylate_cyc	887..1074	CDD:278633	76/188 (40%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002	30/144 (21%)
		HNOBA	224..441	CDD:285003	57/268 (21%)
		CYCc	421..609	CDD:214485	76/193 (39%)
		Guanylate_cyc	453..629	CDD:278633	72/181 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810