Protein Alignment Gyc76C and gcy-25

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001294116.1
• Gene: gcy-25 / 191653
• WormBaseID: WBGene00001549
• Length: 1034
• Species: Caenorhabditis elegans
• Alignment Length: 1057
• Identity: 269/1057 - (25%)
• Similarity: 468/1057 - (44%)
• Gaps: 229/1057 - (21%)

  Fly   113 QSRNIPMISYKCAEYRASAIPTFARTEPPDTQVVKS---------LLALLRYYAWNKFSILYEDV 168
            :::.:..::.:..:...|:.|...:.:...|..:|.         :||:.:...|.:..|:|.:.
 Worm    83 ETQTVSRLALRWHKLYLSSAPLSTKEKESTTIALKPHSLAGTAEVILAMCKSMKWKEIGIIYSEE 147

  Fly   169 WSPVA----DLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVF 229
            ....|    |:|.:|  :.::.||   .|::                        |...:..|..
 Worm   148 TKYTAHAIYDMLAEQ--EDDLKIN---VFLE------------------------TDGLSNTYTI 183

  Fly   230 LGAANSLVDFMSSMETA--------GLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCH 286
            |.:|.:|:.|:::::.:        ..|...|:.::.||.   ::.|...:      .|::.| :
 Worm   184 LHSARALISFLTTLDLSKFFKTLKENAFRPLEFSIVHVDC---NKSEISNF------YTYLDN-N 238

  Fly   287 STENFNQMARSLL-----VVASTPPTKDYIQFTKQ-VQKYSSKPPFNLEIPRLFVESNFSKFISI 345
            :.|..|.::.:.|     .||....:.|.::.|:: .:||...|.:.|                .
 Worm   239 AGEEPNPISAARLRKLYRHVALLKNSHDDMEKTEEFAKKYGLVPSYTL----------------Y 287

  Fly   346 YAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQY 410
            .|..|.|.::|                                                  ::.|
 Worm   288 KALILCDGLQL--------------------------------------------------LNNY 302

  Fly   411 GDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSG------GEK 469
            ....||.|::...|:.||:..|.....:..||...:.|...|.|::..    |..|      ..|
 Worm   303 TAPRGNLSIVQQLPYLWNHVTNTETQGYSGPVFIGNDGVRLPYYEMHM----WRDGKAVHVANVK 363

  Fly   470 PAD------------------EPM----------CGFANELCKKDDTHYTSTVAAVVLGVLLFCS 506
            |.:                  .|:          ||:.|.||  .|.| ...:||:|..:||
 Worm   364 PRESDYCGGNMTKNCYEFLPSSPLLEDLPPYTSDCGYDNNLC--SDFH-VFMIAAIVFSILL--- 422

  Fly   507 GVITMSI--YRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSA--QSYGSRWTNQFV 567
              |.|:|  |.:.|..| |:.:.|::..:.|........:|:..:||.:|.  .||.|      :
 Worm   423 --IPMAIAFYLQRKEHL-IQQMPWRVPLDSISFDDNGGSLSASRRVSTISTARASYSS------I 478

  Fly   568 TSTGRLRGAVVRIKELKFPRKRDISREIM----KEMRLLRELR---HDNINSFIGASV-EPTRIL 624
            .|......|:|  .:.|...||.:.|..:    :||.:|.:|:   |.|||.|.|... :.:.::
 Worm   479 FSGNVAEHAIV--NKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSELI 541

  Fly   625 LVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWML 689
            ::..:..:.||.|:|..::.|....|.::.|..::.|:.|||||.:..||.|..|||||.|.|::
 Worm   542 VMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVV 606

  Fly   690 QVTDFGLHE-LRQCAENESIGEHQ-------HYRNQLWRAPELLRNHI----------HGSQKGD 736
            ::||||:.. |::...::.:....       ||: .|..|||    ||          .|:.:||
 Worm   607 KLTDFGIKGILKERTNHKELAPSSAFDVDAIHYK-YLQLAPE----HISAILEKLEEPRGTVEGD 666

  Fly   737 VYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIR 801
            :|..|:.:|:|.....||.:.....||:...   |..:...|..|:|.   |..|....:|:.|:
 Worm   667 IYQLAMCIYQILFYMRPFAERQESIKELAHL---LSSQSTAPLHPKVP---EGNSFTMRLLSIIQ 725

  Fly   802 DCWAEDPEERPEFSVIRNRLKKMRGGKTK-NIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKT 865
            .||...|..||....|.:.:.:..|...| .::|||:||:::|:.|||.||.||||.|.::...|
 Worm   726 QCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAERTRELEQDMSVT 790

  Fly   866 EDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDR 930
            |:||:::||:|||:.:..|:.|.|..:..||:...|:..||.......|:.::..|.:||:.||.
 Worm   791 ENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAFIPVHILETLQELYSSFDN 855

  Fly   931 IIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGM 995
            |::....:|||.:||||::.||:|..:|.||..||..::|:|...:|..::.|||:.||::::|:
 Worm   856 IVQKNKAFKVENVGDAYLICSGIPEMSGFRHLREICKISLKLQAFMKTFKVRHRPSHTLQIKMGI 920

  Fly   996 HTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVN 1060
            .:|.|.||::|.|.||:|:||||||.|.||.|.|....|.:|......|.:....::.|:||:::
 Worm   921 TSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMID 985

  Fly  1061 MKGKGDVVTWWLTGANE 1077
            :||||..:|:||||..:
 Worm   986 VKGKGACLTFWLTGEKD 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	54/358 (15%)
		PK_GC-A_B	543..827	CDD:270944	85/311 (27%)
		HNOBA	<833..881	CDD:462234	25/47 (53%)
		CYCc	860..1052	CDD:214485	71/191 (37%)
gcy-25	NP_001294116.1	PBP1_NPR_GC-like	54..365	CDD:380575	60/390 (15%)
		Protein Kinases, catalytic domain	473..746	CDD:473864	81/291 (28%)
		HNOBA	<761..805	CDD:462234	23/43 (53%)
		CYCc	790..976	CDD:214485	71/185 (38%)