Protein Alignment Gyc76C and gcy-23

DIOPT Version :9

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_500309.3
• Gene: gcy-23 / 191652
• WormBaseID: WBGene00001548
• Length: 1073
• Species: Caenorhabditis elegans
• Alignment Length: 1194
• Identity: 342/1194 - (28%)
• Similarity: 558/1194 - (46%)
• Gaps: 239/1194 - (20%)

  Fly     1 MTRWPFNLLLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLP 65
            |.|..|..||||.    :|:|.:  :.||::.|: |.::..:.:     |.::.:::.:: .:|.
 Worm     1 MRRELFIFLLLLG----ECANVK--VKVGHIGAV-GSMRNAEKI-----LQLSKEQLTQE-GVLG 52

  Fly    66 NVYLDLRWNDTKGDTVLATKAITEMIC----------------DGIATIFGPEGPCYVEAIVSQS 114
            |.: |:             :.:.:|.|                .|:....||.....::|:...:
 Worm    53 NDF-DI-------------EILNQMGCGESYEGVAVGADMYHVQGVRAFIGPYCNAELDAVAKMA 103

  Fly   115 R--NIPMISYKCAEYR---ASAIPTFARTEPPDT-QVVKSLLALLRYYAWNKFSIL--------- 164
            .  |||::.|..:...   .:...|.||.....| .:.::..||:::|.|||.:|.
 Worm   104 TFWNIPVVGYMASSNSFADKTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKVAIATNTGAVAFE 168

  Fly   165 ----YEDVW-----SPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNT 220
                :|:|:     :.|..::.::.|.....:|                     ||    |:|..
 Worm   169 RVQSFEEVFHQRGINVVRKIMLEEYTNAKAIMN---------------------SG----LLQEL 208

  Fly   221 MNRTRIYV--FLGAANSLVDFMSSMETAGLFARGEYMVIF-------VDMMVYSEREAEKYLRRV 276
            .|..|:.|  |....:...:||.::..:|: ....|..|.       .||..:.....| |.:.|
 Worm   209 ENSARVVVCAFSSTRDMNKEFMQAVTLSGM-NNANYAWILPWLQLETKDMAPWLGENGE-YQQNV 271

  Fly   277 DQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSK 341
            ..  ..:|....::.|....:|:.     |.|:.:    :...||:.   :||:.
 Worm   272 KD--HFANSFIIDDVNGFDNTLVT-----PFKERL----EASGYSTD---DLEMK---------- 312

  Fly   342 FISIYA-AYLYDSVKLYAWAVDKMLRE---ETRVLTDDVIFEVASNGTRV-IDTIIKNRTYMSIT 401
              :||. .:|||:::|||.||...:.|   |...|...   ||.::..|: ...::.|   ..:|
 Worm   313 --NIYGYIHLYDALRLYALAVRATMNETGNENSYLNGK---EVWNHMRRITFPGLVSN---AGVT 369

  Fly   402 GSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFH-QGEEHPEYKLINGSID--- 462
            ...:.:|...:....::.....|    ||:.:.....:.||...: .|.     |..||..:
 Worm   370 SGTVMMDDIAERAPVYAAFYVPP----NSDTVRKVCELEPVMLTNCDGT-----KTGNGCYELQV 425

  Fly   463 -------WPS-GGEKPADEPMCGFANELCKKDDTHYTSTV--AAVVLGVLLFCSGVITMSIYRKW 517
                   ||| .|..|||||.|||.||.|     .||:.:  ..:||.::|.   :|...|..:.
 Worm   426 TDLSTGFWPSIDGSLPADEPACGFRNEKC-----DYTTLIIGGCIVLLIILL---IICFFILSRV 482

  Fly   518 KIELEIEGLLWKIDPNEIKGYSGNE------IVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGA 576
            .....:....|:|..::.:....||      |.||.:|:|.||          .||.... :.|.
 Worm   483 CENRALANTPWRIYRDDFRTIQENEMKSMLSIGSSKTKMSNMS----------MFVKHHA-VVGT 536

  Fly   577 VVRIKELKFPRKRDI--SREIMKEMRLLRELRHDNINSFIGASV-EPTRILLVTDYCAKGSLYDI 638
            ........:|::|.|  :|:.::.:..:::..|||:|.|:|.|. |...::::..:|::|::.|:
 Worm   537 NTHASFHLYPQRRPIVFNRQDLQLLNQMKQAVHDNLNPFLGMSFNEKEEMVVLWKFCSRGTIQDM 601

  Fly   639 IENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDF--------- 694
            |.|:::.||..|..:.|.|:..|:.|:|:|.:.|||:|...:|::...||:::||:
 Worm   602 IYNQEVSLDSKFHGAFIRDITLGLEYLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERW 666

  Fly   695 ---GLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHG----------------SQKGDVYAF 740
               ||.......|.:.........:.|::.||:|:|....                .|.||:|||
 Worm   667 EKLGLISTETLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAF 731

  Fly   741 AIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWA 805
            .::|:||..|..||.. .....|::||::    .|...|||.|..  ..:..||.| |.:.|||.
 Worm   732 GMVMHEILFRALPFPN-GTNVSEVMDYIR----DGTKTFRPTVHD--RTQIHPDLV-ALLLDCWN 788

  Fly   806 EDPEERPEFSVIRNRLK-----KMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKT 865
            |:||.||  |:.|.||.     |::|    :::||||.|||:||||||.:|.|||.:|.|..::.
 Worm   789 ENPEVRP--SIRRVRLNTENYLKVKG----SLVDQMMRMMEQYANNLEKLVAERTGMLEEANVRA 847

  Fly   866 EDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDR 930
            :.||.::||:.||.:|.||:.|...::|:.|:.||||||||.:.:.||||:||:.||.:|:.||.
 Worm   848 DKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSSTPLEVVSMLNSIYSKFDD 912

  Fly   931 IIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGM 995
            .|..:..|||||||||||:|||:|.:||:.|...|.:.||||:..:|.:.|.||.|..|::|:|:
 Worm   913 AINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEIPHRRNVKLRIRLGI 977

  Fly   996 HTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVN 1060
            |||.|.|||||||.|||||||||||.||||||..|..||.:|.:.:....:....:....||.|.
 Worm   978 HTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYSEFQITLRGTVE 1042

  Fly  1061 MKGKGDVVTWWLTG-ANENAIQKK 1083
            .||||.|.::||.| .:|:.:|::
 Worm  1043 AKGKGPVTSYWLLGKQSESQMQQQ 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	85/472 (18%)
		ANF_receptor	48..412	CDD:279440	76/417 (18%)
		PK_GC-A_B	543..827	CDD:270944	90/319 (28%)
		HNOBA	<835..881	CDD:285003	24/45 (53%)
		CYCc	860..1052	CDD:214485	96/191 (50%)
		Guanylate_cyc	887..1074	CDD:278633	96/186 (52%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	80/446 (18%)
		ANF_receptor	38..385	CDD:279440	76/420 (18%)
		PK_GC	509..806	CDD:270894	89/317 (28%)
		HNOBA	<817..863	CDD:285003	24/45 (53%)
		CYCc	842..1035	CDD:214485	96/192 (50%)
		Guanylate_cyc	869..1056	CDD:278633	96/186 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910