DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and gcy-15

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	1140	Identity:	367/1140 - (32%)
Similarity:	577/1140 - (50%)	Gaps:	162/1140 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LTMALDEVNKDPNLLPNVYLDLRWNDTK---GDTVLATKAITEMICDGIATI--FGPEGPCYVEA 109
            :.:|::.:|.|.:|.....||:.:.||.   |.....|.|:..      ||:  .|....||:::
Worm     1 MEIAINRLNADKDLEVFHDLDVNYVDTSKTAGPRAARTAALNN------ATVAAMGLMRDCYIQS 59

  Fly   110 IVSQSRNIPMISYKCAEYRASAIPTFART----EPPDTQVVKSLLALLRYYAWNKFSILYEDVWS 170
            .: .:.|:.:......|...|::..|.:|    ......:.||::..|..|.|.|.:::     |
Worm    60 TI-LNINLKIAVSDVCEMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQWKKVALV-----S 118

  Fly   171 PVADLLKDQATKRN-----MTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYV-- 228
            |.|.|....|..|:     :|.|.....:|:|:   :.|.|..      :.|:....:.||::
Worm   119 PSAVLTAFAARVRSDLLDALTANKIDILVDSRL---DPMSDIT------EKVKEDAEKARIFIIC 174

  Fly   229 -FLGAANSLVDFMSSMETAGLFARGEYMVI-FVDMMV-YSEREAEKYLRRVDQI--TFMSNCHST 288
             :...||.|.:::..:........|||.|: ::.... |...||....:|:..:  :.:::.:.|
Worm   175 DWSSNANLLRNYIFKLGEMNKMQSGEYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLT 239

  Fly   289 EN-FNQMARSLLVVASTPP------TKDYIQFTKQVQKYSSK--PPF-NLEIPRLFVESNFSKFI 343
            || .:::.:::::::..||      |.:.|: |:.::|..:|  ||: |..|.    |....::.
Worm   240 ENDLHEVYKNVVILSDGPPPAEPNSTWEDIK-TQVLKKKPAKMCPPYCNTTIS----EKITPRWD 299

  Fly   344 SIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKID 408
            .|  ..|:||::..|.|.:..|.....:...|:.:|...  :|.:|         |:||....||
Worm   300 RI--KLLFDSIQYLADATNDALNIGANIYQSDIFYEHLI--SRKVD---------SVTGVTEYID 351

  Fly   409 QYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLING-----------SID 462
            .||...|:..:..   |..::|:|   :|.:.|.|...|.      .|:|.           |||
Worm   352 GYGAIVGSMQIYY---HFSSSSHN---SYSLFPCARLAQS------SLLNTVWSLTDYSEGLSID 404

  Fly   463 WPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLL 527
            :.: ...|.|.|:|||..|.|.....:....|.:|.:.||:..: :....:|::::.|..:..|.
Worm   405 FVN-KSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLA-IAAAFLYKRYRYERRLHSLF 467

  Fly   528 WKIDPNEI-----------------KGYSGNEIVSS---------------PSKVSLMSAQSYGS 560
            :.||.|:|                 ....|:.:.:|               .|.::..|..:.||
Worm   468 FMIDRNQIILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASSINASSIFNTGS 532

  Fly   561 -----------------------RWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLL 602
                                   :|........|...|..|.:|.: :....:.:|....|:..|
Worm   533 TARAGPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALKRI-YRSDVEFTRSNRLEIAKL 596

  Fly   603 RELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHN 667
            :|..:.|:..|:|..|:...:.:|.:...:|||.||::|:|:.|||:|.:.:..|:|.|:.|:|:
Worm   597 QESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHS 661

  Fly   668 SQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGS 732
            |.:..||.|||:||::.:|||::::.|||.|||.....:...:.|..::|||.:|||||.....|
Worm   662 SPVGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLS 726

  Fly   733 -------QKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAE 790
                   ||.|||:.||::||:|.|.||:|....||:|||..||:..|.|:.||||::..:.|:
Worm   727 QCGVLLVQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKES- 790

  Fly   791 SCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERT 855
              |..|...:...|.|||..||....|:.:||.:..|..:.|||.|:.|:|||.:.||..:.||.
Worm   791 --PRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERN 853

  Fly   856 RLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNF 920
            ..|..||.|:|.||..|||:.||:.|.:|..|...|::..|::|||..||..|||.|.|:.:|.|
Worm   854 EELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQF 918

  Fly   921 LNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRP 985
            ||||||||||||..:||||||||.|||||.||||:.||:.|||||||:.|.||.||:..:|.|.|
Worm   919 LNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLP 983

  Fly   986 NETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGG 1050
            ||.::|||||::||.|||||||.|||||||||||||||||||||..|:|:.|...|..||:| ||
Worm   984 NEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQL-GG 1047

  Fly  1051 YITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLV 1085
            |..|:||:|.|||||..:|:::.|.|.:..:::::
Worm  1048 YEIEERGIVEMKGKGKQMTYFVRGENSDMRRERII 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	93/425 (22%)
		ANF_receptor	48..412	CDD:279440	85/392 (22%)
		PK_GC-A_B	543..827	CDD:270944	101/328 (31%)
		HNOBA	<835..881	CDD:285003	21/45 (47%)
		CYCc	860..1052	CDD:214485	120/191 (63%)
		Guanylate_cyc	887..1074	CDD:278633	118/186 (63%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822	87/399 (22%)
		PK_GC	553..822	CDD:270894	96/272 (35%)
		HNOBA	<831..879	CDD:400168	23/47 (49%)
		Guanylate_cyc	885..1071	CDD:306677	118/186 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870