DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and gcy-5

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_496219.1	Gene:	gcy-5 / 191643	WormBaseID:	WBGene00001532	Length:	1122	Species:	Caenorhabditis elegans

Alignment Length:	1223	Identity:	357/1223 - (29%)
Similarity:	548/1223 - (44%)	Gaps:	241/1223 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FNLLLLLSVAVRDC----SNHRTVLTVGYLTALTGDLKTRQG----LAISGALTMALDEVNKDPN 62
            |:::||..:...:|    |:.|| |.||...|    ..|:.|    .:..|.|.:|:..: |...
Worm     6 FSMVLLWVLGASECQVIPSSRRT-LRVGIAAA----QDTQSGSIGWASCGGTLPIAVQYL-KSKG 64

  Fly    63 LLPNVYLDLRWNDTKGDTVLATKA----ITEM--------ICDGIATIFGPEGPCYVEAI----- 110
            .|.:..::.....|:.|.....||    :.||        .|.....|.|.....|.:.:
Worm    65 FLTDFDVEYYMEYTECDRASVAKAGMKFMKEMNVDVVVGPSCGDALAIMGTLSAIYKKLVLGWGF 129

  Fly   111 -----VSQSRNIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY----- 165
                 ::.:...|        |.||..|| |:|....|.      .:|..:.:::.::||
Worm   130 VSDTQLADTNRFP--------YVASVQPT-AQTLGLATS------RILEMFQFDRVALLYYKDDQ 179

  Fly   166 ---EDVWSPVADLLKD--------------QATKRNMTINHKQSFIDNRVKCCEQMLDCCRSG-- 211
               :.|...|...|.|              |:....:|.:..|: :.:|.:.   :|.|..||
Worm   180 DYCKSVMDDVEATLSDPDLYPVRIVWKGELQSDNEALTRSTLQA-VKSRARI---VLLCAISGPE 240

  Fly   212 ---YWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAG----------LFARG-----EYMVIF 258
               |...:.|..|          ..|..|..:.:|.:.|          .||.|     |...:.
Worm   241 KRNYLISIAQQNM----------TTNEYVHILLTMRSIGYGVQTSLGKKTFANGLTPLWESFTVA 295

  Fly   259 VD-MMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQF-TKQVQKYS 321
            .| ....:.|.|||.|                        ::.|.|.....:::|: ||.:....
Worm   296 PDGNETNARRAAEKML------------------------VIDVNSDVQDAEFLQYLTKNIADAV 336

  Fly   322 SKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTR 386
            ..||...........|:.|  :..||.:|:|...||..||.|:..      ||..::   .|...
Worm   337 RNPPMKCNTSECINASSTS--MGSYARHLFDVFYLYGMAVSKLNS------TDPTVY---GNLNL 390

  Fly   387 VIDTIIKNRTYMSITGSKIKIDQ----------YGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVP 441
            ::..::  .::..:|| :::|.|          ||..|....|.......:|:|:.:...|....
Worm   391 LMPQMV--TSFDGMTG-RVQIGQNLYRVPTYQLYGLDEKYEQVALVNMTFYNSSSQLSRGYSDEG 452

  Fly   442 VAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKK---DDTHYTSTVAAVVL---- 499
            .:.:|               .|  .|.:|.|.|:|||:...|..   |.......||::||
Worm   453 RSVWH---------------FW--DGTRPLDTPICGFSGRYCPVQFWDQYGVLIFVASIVLIFLI 500

  Fly   500 GVLLFCSGVITMSIYRKWKIELEIEGLLWKI-------------DPNEIKG-YSGNEIVSSPSKV 550
            .::|.|.|.    :.|..:.|.|.....|:|             .||..:. .||...::..||:
Worm   501 CIMLMCFGF----MIRGRRAEQERLNSEWQIPSIQLIMPQKEKRKPNSRRSLQSGPSTITGESKM 561

  Fly   551 SLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKR---DISREIMKEMRLLRELRHDNINS 612
            ::..  .:...:|.|...            |:|....|.   .:::|..::...||:|.|||:|.
Worm   562 TIDG--GFHENYTVQMFE------------KDLVLTTKHHSMQMNKEEKEKFVKLRKLEHDNLNK 612

  Fly   613 FIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLK 677
            |||.|::..:.:.|...|::|||.|||...:..:|..|:..:|.|:.:||.::|.|.|..||||:
Worm   613 FIGLSIDGPQFVAVWKMCSRGSLQDIIARGNFSMDGFFMFCIITDIAEGMNFLHKSFLHLHGNLR 677

  Fly   678 SSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQ-LWRAPELLRNHIHGSQ---KGDVY 738
            |:.|:|...|.:::|||||..|        :.||...:.: ||.|||:||..:...|   ..|||
Worm   678 SATCLVNDSWQVKLTDFGLGAL--------LEEHTPSKKRLLWAAPEVLRGSLTIHQMDPSADVY 734

  Fly   739 AFAIIMYEIFSRKGPFGQINFE--PKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIR 801
            :||||..||.:::..:...|.:  ..||:..|||   .|....|||:  |::||..| .:...::
Worm   735 SFAIIASEILTKREAWDISNRKEGADEILYMVKK---GGNRTIRPEL--ILDAEVSP-RLTTLVK 793

  Fly   802 DCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTE 866
            |||:|.||:||:...|...|.:|......|:||.:..|:|:|.:.||..:.|||:.|..||.|.:
Worm   794 DCWSEQPEDRPKAEQICKLLSEMTPRGNTNLMDHVFNMLEEYTSTLEVDIEERTKELTLEKKKAD 858

  Fly   867 DLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRI 931
            .||.||||:.|||:|..||.|||..:|.||:.|||:|.||.::|:.:|.||||.|||||:.||.|
Worm   859 ILLSRMLPKQVAERLKAGQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDTI 923

  Fly   932 IRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMH 996
            |..:.|||||:|||.|:.|||||.|||..|..:|..|:|:.:...|..::.|.|.|.::||||::
Worm   924 IEEHGVYKVESIGDGYLCVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGIN 988

  Fly   997 TGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKC-KLALDKLGGGYITEKRGLVN 1060
            :||.|||||||:|||||||||||||||||||||:...||:|... .|..|.....|.|..||.|.
Worm   989 SGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSSRGEVI 1053

  Fly  1061 MKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSI 1113
            :||||.:.|:|:.|..::  ..|.:.....||  .:.....|::..|.::.::
Worm  1054 IKGKGVMETFWVLGKTDS--DTKSLSTRTTPP--ITDENWPPQMKEDLKKRAV 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	94/498 (19%)
		ANF_receptor	48..412	CDD:279440	82/439 (19%)
		PK_GC-A_B	543..827	CDD:270944	94/292 (32%)
		HNOBA	<835..881	CDD:285003	21/45 (47%)
		CYCc	860..1052	CDD:214485	106/192 (55%)
		Guanylate_cyc	887..1074	CDD:278633	102/187 (55%)
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347	90/481 (19%)
		ANF_receptor	49..426	CDD:279440	83/444 (19%)
		PK_GC	546..816	CDD:270894	95/297 (32%)
		HNOBA	<830..873	CDD:285003	21/42 (50%)
		CYCc	852..1042	CDD:214485	106/189 (56%)
		Guanylate_cyc	879..1067	CDD:278633	102/187 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910